Results 151 to 160 of about 508,309 (264)
Protein glycosylation in lung cancer from a mass spectrometry perspective
Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi +2 more
wiley +1 more source
Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]
, 2014 Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P. +2 more
core
Allergy, Volume 81, Issue 5, Page 1500-1521, May 2026.This study comprehended the allergen profiles of six edible crab species using proteomic and transcriptomic analyses and identified 11 putative allergens. King crab has a distinct protein and allergen profile, with the discovery of malate dehydrogenase as a novel king crab‐specific allergen registered as Para c 11.
Shanshan Li +11 more
wiley +1 more source
Evolutionary Applications, Volume 19, Issue 5, May 2026.ABSTRACT Crustaceans, such as shrimp and crabs, are pivotal to global aquaculture, yet their productivity is severely impacted by low‐temperature stress. This study employs comparative transcriptomic and genomic analyses to elucidate the molecular mechanisms underlying crustacean responses to cold stress across five economically significant species ...
Ying Chen +7 more
wiley +1 more source
CD24 in Melanoma: Biomarker, Innate Immune Checkpoint and Emerging Therapeutic Target
Experimental Dermatology, Volume 35, Issue 5, May 2026.ABSTRACT Immune checkpoint inhibitors have transformed the treatment of advanced melanoma, yet many patients develop primary or acquired resistance. Although most work has focused on adaptive checkpoints (PD‐1 and CTLA‐4), accumulating evidence implicates innate immune suppression and stem‐like, drug‐resistant melanoma cell states.
Claudia Lasalle +6 more
wiley +1 more source
The Hemoprotein Hhy1 Promotes Heme‐Dependent Catalase Activity of Ctt1
Molecular Microbiology, Volume 125, Issue 5, Page 389-411, May 2026.A Schizosaccharomyces pombe strain deficient in heme (hem1Δ) and siderophore (Fc) biosynthesis, as well as high‐affinity iron (Fe) uptake (blue), was used to uncover the hemoprotein Hhy1 that promotes the heme‐dependent activity of the catalase Ctt1. In contrast, hhy1Δ cells exhibit reduced Ctt1 activity and increased sensitivity to oxidative stress ...
Tobias Vahsen +3 more
wiley +1 more source
Lipid rafts: cell surface platforms for T cell signaling
Biological Research, 2002 The Src family tyrosine kinase Lck is essential for T cell development and T cell receptor (TCR)* signaling. Lck is post-translationally fatty acylated at its N-terminus conferring membrane targeting and concentration in plasma membrane lipid rafts ...
TONY MAGEE +4 more
doaj
The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu +7 more
wiley +1 more source
Expression and Circular Dichroism Studies of the Extracellular Domain of the alpha Subunit of the Nicotinic Acetylcholine Receptor [PDF]
, 1997 To provide material suitable for structural studies of the nicotinic acetylcholine receptor, we have expressed and purified the NH2-terminal extracellular domain of the mouse muscle alpha subunit.
Bjorkman, Pamela J. +3 more
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