Results 11 to 20 of about 56,362 (206)
Frontiers in Medicine, 2022 Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue +23 more
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Complementation of essential yeast GPI mannosyltransferase mutations suggests a novel specificity for certain Trypanosoma and Plasmodium PigB proteins. [PDF]
PLoS ONE, 2014 The glycosylphosphatidylinositol (GPI) anchor is an essential glycolipid that tethers certain eukaryotic proteins to the cell surface. The core structure of the GPI anchor is remarkably well conserved across evolution and consists of NH2-CH2-CH2-PO4 ...
Leslie K Cortes +2 more
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The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. [PDF]
The Journal of cell biology, 1995 The urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-linked glycoprotein, plays a central role in the regulation of pericellular proteolysis and participates in events leading to cell activation. Here, we demonstrate that uPAR, on a human melanoma cell line, is localized in caveolae, flask-shaped microinvaginations of the
A, Stahl, B M, Mueller
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Frontiers in Immunology, 2023 HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient.
Weiming Wang +9 more
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Expression of unique sets of GPI-linked proteins by different primary neurons in vitro. [PDF]
The Journal of cell biology, 1992 We have surveyed the proteins expressed at the surface of different primary neurons as a first step in elucidating how axons regulate their ensheathment by glial cells. We characterized the surface proteins of dorsal root ganglion neurons, superior cervical ganglion neurons, and cerebellar granule cells which are myelinated, ensheathed but unmyelinated,
C L, Rosen, M P, Lisanti, J L, Salzer
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Implications of lipid moiety in oligomerization and immunoreactivities of GPI-anchored proteins
Journal of Lipid Research, 2013 Glycosylphosphatidylinositol (GPI) enriches GPI-anchored proteins (GPI-AP) in lipid rafts by intimate interaction of its lipid moiety with sphingolipids and cholesterol.
Jihyoun Seong +3 more
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In Vitro PIG-A Gene Mutation Assay in Human B-Lymphoblastoid TK6 Cells
Pharmaceutical Fronts, 2021 The X-linked PIG-A gene is involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. PIG-A mutant cells fail to synthesize GPI and to express GPI-anchored protein markers (e.g., CD59 and CD55).
Chang-Hui Zhou +8 more
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Endoplasmic Reticulum Export of GPI-Anchored Proteins [PDF]
, 2019 Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo to the Golgi apparatus ...
López Martín, Sergio +3 more
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The growth suppressing gas1 product is a GPI‐linked protein
FEBS Letters, 2000 Growth arrest specific (gas) 1 gene product is expressed in non‐transformed fibroblasts in response to stimuli driving cells into Go phase. Gas1 has been demonstrated to inhibit cell proliferation when over‐expressed in proliferating fibroblasts. This activity depends on a function of the p53 protein independent of its transactivating ability.
STEBEL M. +5 more
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Nanoclustering as a dominant feature of plasma membrane organization [PDF]
, 2014 Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane ...
Cambi, Alessandra +4 more
core +5 more sources