The cation‐independent mannose‐6‐phosphate receptor binds to soluble GPI‐linked proteins via mannose‐6‐phosphate [PDF]
FEBS Letters, 1995 The cation‐independent mannose‐6‐phosphate/insulin‐like growth factor II receptor has been observed to bind to soluble forms of glycosyl‐phosphatidylinositol‐linked molecules, one of mammalian origin (rat Thy‐1) and two of protozoan origins. Of the two phosphate groups found on the soluble forms of the protozoan glycosyl‐phosphatidylinositol‐linked ...
Green, Paula J. +3 more
openaire +4 more sources
GPI-AP release in cellular, developmental, and reproductive biology
Journal of Lipid Research, 2016 Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contain a covalently linked GPI anchor located on outer cell membranes. GPI-APs are ubiquitously conserved from protozoa to vertebrates and are critical for physiological events such as development,
Yoshitaka Fujihara, Masahito Ikawa
doaj +1 more source
Frontiers in Microbiology, 2021 The fungal cell wall is composed of a cross-linked matrix of chitin, glucans, mannans, galactomannans, and cell wall proteins with mannan chains. Cell wall mannans are directly attached to the cell wall core, while the majority of mannoproteins is ...
Lea Atanasova +6 more
doaj +1 more source
Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle [PDF]
, 2017 Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp.
Blake, D P +4 more
core +1 more source
Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. [PDF]
, 2012 Mesothelial cells are critical in the pathogenesis of post-surgical intraabdominal adhesions as well as in the deterioration of the peritoneal membrane associated with long-term peritoneal dialysis.
Djafarzadeh, Roghieh +10 more
core +5 more sources
Neurobiology of Disease, 2020 Many aggregation-prone proteins linked to neurodegenerative disease are post-translationally modified during their biogenesis. In vivo pathogenesis studies have suggested that the presence of post-translational modifications can shift the aggregate ...
Julia A. Callender +9 more
doaj +1 more source
Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]
, 2010 The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter
core +1 more source
Growth factor‐induced release of a glycosyl‐phosphatidylinositol (GPI)‐linked protein from the HEp‐2 human carcinoma cell line [PDF]
FEBS Letters, 1990 The release of a GPI‐linked oncofetal protein (PLAP) from HEp‐2 cells has been studied as an indicator of endogenous PI‐specific PLC activation. A non‐hydrolysable GTP analogue, EGF and insulin all produced a dose‐dependent release of PLAP from these cells.
Roberts, Julia M. +2 more
openaire +2 more sources
Nanoscale effects of ethanol and naltrexone on protein organization in the plasma membrane studied by photoactivated localization microscopy (PALM). [PDF]
PLoS ONE, 2014 BACKGROUND: Ethanol affects the signaling of several important neurotransmitter and neuromodulator systems in the CNS. It has been recently proposed that ethanol alters the dynamic lateral organization of proteins and lipids in the plasma membrane ...
Steven J Tobin +5 more
doaj +1 more source
A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]
, 2016 Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I +2 more
core +1 more source