Results 61 to 70 of about 56,362 (206)

SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

Advanced Science, EarlyView.
This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen, Lihua Yang, Shuang Cai, Yunxia Liu, Jianan Fan, Peng Wu, Beibei Gao, Xiaoge Xie, Hong Sun, Sida Qin, Qiao Yi Chen   +10 more
wiley   +1 more source

Strain and temperature dependent aggregation of Candida auris is attenuated by inhibition of surface amyloid proteins

The Cell Surface, 2023
Candida auris is a multi-drug resistant human fungal pathogen that has become a global threat to human health due to its drug resistant phenotype, persistence in the hospital environment and propensity for patient to patient spread.
Dhara Malavia-Jones, Rhys A. Farrer, Mark H.T. Stappers, Matt B. Edmondson, Andrew M. Borman, Elizabeth M. Johnson, Peter N. Lipke, Neil A.R. Gow   +7 more
doaj   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers.

PLoS Genetics
Mutations in glycosylation pathways, such as N-linked glycosylation, O-linked glycosylation, and GPI anchor synthesis, lead to Congenital Disorders of Glycosylation (CDG).
Holly J Thorpe, Raghavendran Partha, Jordan Little, Nathan L Clark, Clement Y Chow   +4 more
doaj   +1 more source

Isolation and purification of glycosylphosphatidylinositols (GPIs) in the schizont stage of Theileria annulata and determination of antibody response to GPI anchors in vaccinated and infected animals

Parasites & Vectors, 2018
Background Tropical theileriosis is widely distributed from North Africa to East Asia. It is a tick-borne disease caused by Theileria annulata, an obligate two-host intracellular protozoan parasite of cattle.
Toktam Abbasnia, Ahmad Asoodeh, Gholamreza Habibi, Alireza Haghparast   +3 more
doaj   +1 more source

Proteomic Analysis to Identify Tightly-Bound Cell Wall Protein in Rice Calli. [PDF]

, 2015
Rice is a model plant widely used for basic and applied research programs. Plant cell wall proteins play key roles in a broad range of biological processes. However, presently, knowledge on the rice cell wall proteome is rudimentary in nature.
Chen, Xiong Yan, Cho, Won Kyong, Hyun, Tae Kyung, Jo, Yeonhwa, Kim, Jae-Yean, Kim, Suwha, Kumar, Dhinesh, Lee, Keun Woo, Lucas, William J, Park, Zee-Yong, Rim, Yeonggil   +10 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Hemoglobinúria paroxística noturna: relato de dois casos Paroxysmal nocturnal hemoglobinuria: two case reports

Revista Brasileira de Hematologia e Hemoterapia, 2002
A Hemoglobina Paroxística Noturna (HPN) é uma doença adquirida da stem cell hematopoética caracterizada por anemia hemolítica crônica, episódios trombóticos, e com freqüência pancitopenia. É uma desordem clonal, causada por mutação somática do gene PIG-A
Carlos J. Araújo, Francisca V.M. Soares, Francisco D. Rocha, Herivaldo F. Silva, José O.L. Nogueira, José W. Correia, Manoel P.G. Guimarães   +6 more
doaj   +1 more source

A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]

, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady, Isabelle Coppens, Jessica C. Kissinger, Leandro Lemgruber, Nathan M. Chasen, Rossiane C. Vommaro, Silvia N. J. Moreno, William J. Sullivan   +7 more
core   +2 more sources

Lifelong Evolution of Autoreactive Plasma Cell Numbers, Affinity, and Anatomic Location in Arthritic K/BxN Mice

Arthritis &Rheumatology, EarlyView.
Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Thibault Vanhoucke, Carlos Castrillon, Odile Richard‐Le Goff, Angga Perima, Matteo Broketa, Andrew D. Griffiths, Patrick England, François Huetz, Pierre Bruhns   +8 more
wiley   +1 more source