Discovery of novel GPVI receptor antagonists by structure-based repurposing. [PDF]
PLoS ONE, 2014 Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug 'resistance', underpinning a drive for new antiplatelet ...
Lewis Taylor +6 more
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A naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency [PDF]
Frontiers in PharmacologyBackgroundBleeding is the inherent adverse effect of antiplatelet drugs that has limited their use in the prevention of secondary heart attack and stroke.
Wan-Jung Lu +13 more
doaj +2 more sources
Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic +74 more
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Soluble Glycoprotein VI Levels Assessed Locally within the Extra- and Intracerebral Circulation in Hyper-Acute Thromboembolic Stroke: A Pilot Study [PDF]
BiomedicinesBackground: Severe acute ischemic stroke (AIS) is mainly caused by thromboembolism originating from symptomatic carotid artery (ICA) stenosis or in the heart due to atrial fibrillation.
Andreas Starke +7 more
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Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach. [PDF]
PLoS Computational Biology, 2015 We present a data-driven mathematical model of a key initiating step in platelet activation, a central process in the prevention of bleeding following Injury.
Joanne L Dunster +4 more
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PLoS ONE, 2022 ObjectivesPlatelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation.
Isuru Induruwa +17 more
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Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets
Biomedicines, 2023 Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic
Chao Han +15 more
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Research and Practice in Thrombosis and Haemostasis, 2022 Background In the fibrin‐forming process, thrombin cleaves fibrinogen to fibrin, which form fibrils and then fibers, producing a gel‐like clot. Thrombin also activates coagulation factor XIII (FXIII), which crosslinks fibrin γ‐chains and α‐chains ...
Masaaki Moroi +3 more
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Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. [PDF]
PLoS ONE, 2014 We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation.
Naadiya Carrim +5 more
doaj +1 more source
Thrombosis Journal, 2022 Background Continuous agitation during storage slows down the platelet storage lesions. However, in special circumstances, manual-mixing can be alternatively used to store products for short time periods without compromising platelet quality.
Ehteramolsadat Hosseini +4 more
doaj +1 more source