Results 1 to 10 of about 6,202 (185)

Fibrin and D-dimer bind to monomeric GPVI [PDF]

Blood Advances, 2017
: Fibrin has recently been shown to activate platelets through the immunoglobulin receptor glycoprotein VI (GPVI). In the present study, we show that spreading of human platelets on fibrin is abolished in patients deficient in GPVI, confirming that ...
Marie-Blanche Onselaer, Alexander T. Hardy, Clare Wilson, Ximena Sanchez, Amir K. Babar, Jeanette L.C. Miller, Callum N. Watson, Stephanie K. Watson, Arkadiusz Bonna, Helen Philippou, Andrew B. Herr, Diego Mezzano, Robert A.S. Ariëns, Steve P. Watson   +13 more
doaj   +2 more sources

Receptor-Dependent and -Independent Effects of Hemin on Platelet Plasma Membrane Disintegration. [PDF]

FASEB J
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Laspa Z, Rohlfing AK, Hochuli R, Sowa PW, Castor T, Gawaz MP.   +5 more
europepmc   +2 more sources

Platelet dysfunction in immune thrombocytopenia: Finding clinical subsets with platelet phenotypes. [PDF]

Br J Haematol
Summary Patients with immune thrombocytopenia (ITP) remain a challenge to diagnose, manage and predict bleeding risk. A comprehensive assessment of platelet function may aid clinical management. This study assessed platelet parameters to predict bleeding in ITP.
Ali SA, Hicks SM, Coupland LA, Brysland SA, Bhoopalan V, Thong YL, Kaur A, Andrews RK, Gardiner EE, Choi PY.   +9 more
europepmc   +2 more sources

Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation. [PDF]

Acta Physiol (Oxf)
ABSTRACT Background Inflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
de Haan SJ, van Buul JD.
europepmc   +2 more sources

Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. [PDF]

PLoS ONE, 2014
We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation.
Naadiya Carrim, Tony G Walsh, Alessandra Consonni, Mauro Torti, Michael C Berndt, Pat Metharom   +5 more
doaj   +3 more sources

Preparation of cold-stored platelets on-demand: A novel approach to inventory management. [PDF]

Transfusion
Abstract Background Cold‐stored platelets (CSP) are now being used to treat acute bleeding. However, as CSP are less suitable for prophylaxis, both room temperature (RT) platelets and CSP will be required, which complicates inventory management. The production of CSP “on‐demand” from RT platelets may be a desirable option.
Johnson L, Waters L, Roan C, Lei P, Mahajan J, Portier M, Winskel-Wood B, Marks DC.   +7 more
europepmc   +2 more sources

A naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency [PDF]

Frontiers in Pharmacology
BackgroundBleeding is the inherent adverse effect of antiplatelet drugs that has limited their use in the prevention of secondary heart attack and stroke.
Wan-Jung Lu, Wan-Jung Lu, Jiun-Yi Li, Jiun-Yi Li, Tzenge-Lien Shih, Ray-Jade Chen, Ray-Jade Chen, Ting-Yu Chen, Ting-Yu Chen, Wei-Ting Kao, Jen-Wei Liu, Hsueh-Hsiao Wang, Hsien-Yu Peng, Kuan-Hung Lin   +13 more
doaj   +2 more sources

In Vitro Comparison of Device-Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps. [PDF]

Artif Organs
This in vitro comparative study demonstrated that the HeartMate 3 pump has a superior overall hemocompatibility profile to the HeartMate 2 pump, underscoring the advantages of the maglev centrifugal pump design compared to the axial pump design. ABSTRACT Background Left ventricular assist devices (LVADs) have been utilized to maintain the circulatory ...
Vandenberge J, Han D, Sun W, Wang S, Tran D, Kim N, Clark K, Perez R, Griffith BP, Wu ZJ.   +9 more
europepmc   +2 more sources

Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results.

PLoS ONE, 2022
ObjectivesPlatelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation.
Isuru Induruwa, Harriet McKinney, Carly Kempster, Patrick Thomas, Joana Batista, Jean-Daniel Malcor, Arkadiusz Bonna, Joanne McGee, Elaine Bumanlag-Amis, Karola Rehnstrom, Sophie Ashford, Kenji Soejima, Willem Ouwehand, Richard Farndale, Kate Downes, Elizabeth Warburton, Masaaki Moroi, Stephanie Jung   +17 more
doaj   +1 more source

Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets

Biomedicines, 2023
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic
Chao Han, Pengxuan Ren, Medina Mamtimin, Linus Kruk, Edita Sarukhanyan, Chenyu Li, Hans-Joachim Anders, Thomas Dandekar, Irena Krueger, Margitta Elvers, Silvia Goebel, Kristin Adler, Götz Münch, Thomas Gudermann, Attila Braun, Elmina Mammadova-Bach   +15 more
doaj   +1 more source