Results 11 to 20 of about 8,801 (259)

GPVI expression is linked to platelet size, age, and reactivity [PDF]

Blood Advances, 2022
Abstract Platelets within one individual display heterogeneity in reactivity, size, age, and expression of surface receptors. To investigate the combined intraindividual contribution of platelet size, platelet age, and receptor expression levels on the reactivity of platelets, we studied fractions of large and small platelets from ...
Alicia Veninga, Stefan Handtke, Konstanze Aurich, Bibian M. E. Tullemans, Sanne L. N. Brouns, S Schwarz, Floor Heubel-Moenen, Andreas Greinacher, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Thomas Thiele   +10 more
semanticscholar   +4 more sources

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis [PDF]

Frontiers in Pharmacology, 2023
Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation in vitro and explored the effect of luteolin on thrombosis ...
Yujia Ye, Lihong Yang, Min Leng, Qian Wang, Jiankui Wu, Wen Wan, Huawei Wang, Longjun Li, Yunzhu Peng, Shengjie Chai, Zhaohui Meng   +10 more
doaj   +3 more sources

Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation [PDF]

Research
Platelet activation contributes to sepsis development, leading to microthrombosis and increased inflammation, which results in disseminated intravascular coagulation and multiple organ dysfunction.
Weichen Xiong, Jinwei Chai, Jiena Wu, Jiali Li, Wancheng Lu, Maolin Tian, Mohamed Amine Jmel, Johannes H. Ippel, Michail Kotsyfakis, Ingrid Dijkgraaf, Shuwen Liu, Xueqing Xu   +11 more
doaj   +3 more sources

Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear [PDF]

Journal of Thrombosis and Haemostasis, 2022
Background: Collagen-induced platelet activation is predominantly mediated by glycoprotein (GP) VI through formation of receptor clusters that coincide with the accumulation of signaling molecules and are hypothesized to drive strong and sustained ...
Farndale, Richard W, Heemskerk, Johan W M, Henskens, Yvonne M C, Jooss, Natalie J, Pike, Jeremy A, Poulter, Natalie S, Smith, Christopher W, Watson, Steve P   +7 more
core   +2 more sources

Factor XIII is a newly identified binding partner for platelet collagen receptor GPVI‐dimer—An interaction that may modulate fibrin crosslinking

Research and Practice in Thrombosis and Haemostasis, 2022
Background In the fibrin‐forming process, thrombin cleaves fibrinogen to fibrin, which form fibrils and then fibers, producing a gel‐like clot. Thrombin also activates coagulation factor XIII (FXIII), which crosslinks fibrin γ‐chains and α‐chains ...
Masaaki Moroi, Isuru Induruwa, Richard W. Farndale, Stephanie M. Jung   +3 more
doaj   +2 more sources

Agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage

Thrombosis Journal, 2022
Background Continuous agitation during storage slows down the platelet storage lesions. However, in special circumstances, manual-mixing can be alternatively used to store products for short time periods without compromising platelet quality.
Ehteramolsadat Hosseini, Amin Solouki, Masood Haghshenas, Mehran Ghasemzadeh, Simone M. Schoenwaelder   +4 more
doaj   +2 more sources

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer [PDF]

Blood, 2021
Abstract Glycoprotein VI (GPVI) is the major signaling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 loops, against recombinant GPVI-Fc (dimeric GPVI) and have characterized their ability to bind recombinant GPVI, resting and ...
Joanne C. Clark, Ying Di, Natalie S. Poulter, Jonas Emsley, Jonas Emsley, Natalie J Jooss, Natalie J Jooss, Eleyna M. Martin, Mark R Thomas, Andrew B. Herr, Robert A. S. Ariëns, Fawaz Obaidullah Alenazy, Stephen P. Watson, Alexandre Slater   +13 more
openaire   +5 more sources

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation

Journal of Thrombosis and Haemostasis, 2022
The collagen receptor glycoprotein VI (GPVI) is an attractive antiplatelet target due to its critical role in thrombosis but minor involvement in hemostasis.To investigate GPVI receptor involvement in platelet activation by collagen-I and atherosclerotic plaque using novel blocking and non-blocking anti-GPVI nanobodies (Nbs).Nb effects on GPVI-mediated
Natalie J. Jooss, Christopher W. Smith, Alexandre Slater, Samantha J. Montague, Ying Di, Christopher O'Shea, Mark R. Thomas, Yvonne M.C. Henskens, Johan W.M. Heemskerk, Steve P. Watson, Natalie S. Poulter   +10 more
openaire   +3 more sources

Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation

Thrombosis and Haemostasis, 2021
AbstractCollagen has been proposed to bind to a unique epitope in dimeric glycoprotein VI (GPVI) and the number of GPVI dimers has been reported to increase upon platelet activation. However, in contrast, the crystal structure of GPVI in complex with collagen-related peptide (CRP) showed binding distinct from the site of dimerization.
Mark Soave, Bernhard Nieswandt, Stephen J. Hill, Dirk-Peter Herten, Dirk-Peter Herten, Dirk-Peter Herten, Alexandre Slater, Eleyna M. Martin, Joanne C. Clark, Joanne C. Clark, David Stegner, Raluca A. I. Neagoe, Raluca A. I. Neagoe, Malou Zuidscherwoude, Malou Zuidscherwoude, Michael G. Tomlinson, Michael G. Tomlinson, Johan Hummert, Johan Hummert, Johan Hummert, Deirdre M. Kavanagh, Deirdre M. Kavanagh, Natalie S. Poulter, Natalie S. Poulter, Steve P. Watson, Steve P. Watson   +25 more
openaire   +5 more sources

Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry

Platelets, 2022
Src tyrosine kinases and spleen tyrosine kinase (Syk) have recently been shown to contribute to sustained platelet aggregation on collagen under arterial shear.
Hilaire Yam Fung Cheung, Luis A. Moran, Albert Sickmann, Johan W.M. Heemskerk, Ángel Garcia, Steve P. Watson   +5 more
doaj   +2 more sources