Results 21 to 30 of about 8,801 (259)

Discovery of novel GPVI receptor antagonists by structure-based repurposing. [PDF]

PLoS ONE, 2014
Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug 'resistance', underpinning a drive for new antiplatelet ...
Lewis Taylor, Sridhar R Vasudevan, Chris I Jones, Jonathan M Gibbins, Grant C Churchill, R Duncan Campbell, Carmen H Coxon   +6 more
doaj   +7 more sources

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation

International Journal of Molecular Sciences, 2022
Rac1 is a small Rho GTPase that is activated in platelets upon stimulation with various ligands, including collagen and thrombin, which are ligands for the glycoprotein VI (GPVI) receptor and the protease-activated receptors, respectively. Rac1-deficient murine platelets have impaired lamellipodia formation, aggregation, and reduced PLCγ2 activation ...
Raluca A. I. Neagoe, Elizabeth E. Gardiner, David Stegner, Bernhard Nieswandt, Steve P. Watson, Natalie S. Poulter   +5 more
openaire   +4 more sources

Liver-mediated shedding of platelet GPVI [PDF]

Blood, 2016
The in vivo mechanisms underlying antibody-based shedding of the key platelet collagen receptor glycoprotein VI (GPVI) are potentially significant for future antibody-based thromboprotective agents.
Michael C. Berndt, Robert K. Andrews
openalex   +5 more sources

mTOR regulates GPVI-mediated platelet activation [PDF]

Journal of Translational Medicine, 2021
Abstract Background Due to mTOR (mammalian/mechanistic target of rapamycin) gene-loss mice die during embryonic development, the role of mTOR in platelets has not been evaluated using gene knockout technology. Methods A mouse model with megakaryocyte/platelet-specific ...
Longsheng Wang, Weihong Xu, Nannan Wu, Shuang Han, Qiaoyun Liu, Cunji Gao, Cunji Gao, Baiyun Dai, Zhihua Chen, Dajing Xia, Gang Liu, Fang Huang   +11 more
openaire   +5 more sources

Fibrin and D-dimer bind to monomeric GPVI [PDF]

Blood Advances, 2017
: Fibrin has recently been shown to activate platelets through the immunoglobulin receptor glycoprotein VI (GPVI). In the present study, we show that spreading of human platelets on fibrin is abolished in patients deficient in GPVI, confirming that ...
Marie-Blanche Onselaer, Alexander T. Hardy, Clare Wilson, Ximena Sanchez, Amir K. Babar, Jeanette L.C. Miller, Callum N. Watson, Stephanie K. Watson, Arkadiusz Bonna, Helen Philippou, Andrew B. Herr, Diego Mezzano, Robert A.S. Ariëns, Steve P. Watson   +13 more
doaj   +6 more sources

Platelet-collagen interaction: is GPVI the central receptor?

Blood, 2003
AbstractAt sites of vascular injury, platelets come into contact with subendothelial collagen, which triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib (GPIb) and αIIbβ3 integrin, which indirectly interact with collagen via von Willebrand factor (VWF), several collagen receptors have been identified on platelets ...
Bernhard Nieswandt, Steve P. Watson
openalex   +4 more sources

Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies. [PDF]

Journal of the American College of Cardiology, 2015
BACKGROUND: Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential.
Bianchini, Mariaelvy, Brandl, Richard, Elia, Natalie, Farndale, Richard, Faussner, Alexander, Goyal, Pankaj, Jamasbi, Janina, Jung, Stephanie, Lorenz, Reinhard, Megens, Remco TA, Münch, Götz, Sherman, Shachar, Siess, Wolfgang, Ungerer, Martin, Walker, Adam, Weber, Christian   +15 more
core   +5 more sources

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice [PDF]

Haematologica, 2019
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes   +9 more
doaj   +4 more sources

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach. [PDF]

PLoS Computational Biology, 2015
We present a data-driven mathematical model of a key initiating step in platelet activation, a central process in the prevention of bleeding following Injury.
Joanne L Dunster, Francoise Mazet, Michael J Fry, Jonathan M Gibbins, Marcus J Tindall   +4 more
doaj   +3 more sources

Soluble Glycoprotein VI Levels Assessed Locally within the Extra- and Intracerebral Circulation in Hyper-Acute Thromboembolic Stroke: A Pilot Study [PDF]

Biomedicines
Background: Severe acute ischemic stroke (AIS) is mainly caused by thromboembolism originating from symptomatic carotid artery (ICA) stenosis or in the heart due to atrial fibrillation.
Andreas Starke, Alexander M. Kollikowski, Vivian Vogt, Guido Stoll, Bernhard Nieswandt, Mirko Pham, David Stegner, Michael K. Schuhmann   +7 more
doaj   +2 more sources