Results 21 to 30 of about 8,521 (239)

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation [PDF]

Thrombosis and Haemostasis, 2018
AbstractPlatelet activators stimulate post-translational modification of signalling proteins to change their activity or their molecular interactions leading to signal propagation. One covalent modification is attachment of the small protein ubiquitin to lysine residues in target proteins.
Amanda J. Unsworth, Izabela Bombik, Adán Pinto-Fernández, Joanna F. McGouran, Rebecca Konietzny, René P. Zahedi, Steve P. Watson, Benedikt M. Kessler, Catherine J. Pears   +8 more
openalex   +6 more sources

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Abtahian, Aguado, Andrews, Auger, Booth, Clements, Clements, Dawood, Eble, Finco, Fuller, Garcia, Hughan, Huysamen, Ishiai, Jordan, Judd, Judd, Kalia, Liu, Liu, McCarty, McCarty, Pasquet, Paz, Perez-Villar, Sarratt, Seet, Shen, Sommers, Suzuki-Inoue, Suzuki-Inoue, Tomlinson, Yablonski, Yablonski, Yoder, Zhang, Zhang, Zhang   +38 more
core   +4 more sources

Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction [PDF]

Frontiers in Immunology
IntroductionPlatelets play an important role in cardiovascular diseases. After acute myocardial infarction, platelets display enhanced activation and migrate into the infarct zone.
Friedrich Reusswig, Matthias Dille, E. Krüger, J. Ortscheid, Tobias Feige, S. Gorressen, J.-W. Fischer, Margitta Elvers   +7 more
doaj   +2 more sources

Association of polymorphisms of platelet receptors GPIa (807C>T), GPVI (13254T>C), and P2Y12 (34C>T and H1/H2 haplotype) with increased risk of periprocedural bleeding in patients undergoing coronary angiography/percutaneous coronary intervention [PDF]

Advances in Interventional Cardiology, 2017
Introduction: Periprocedural bleeding related to coronary angiography (CAG) or percutaneous coronary intervention (PCI) is associated with worse prognosis. Determining genetic variations associated with increased bleeding risk may help to identify high-
Magdalena Sionova, Peter Blasko, Stepan Jirous, David Vindis, Richard Rokyta, Zuzana Motovska   +5 more
doaj   +2 more sources

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer [PDF]

Blood, 2021
Abstract Glycoprotein VI (GPVI) is the major signaling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 loops, against recombinant GPVI-Fc (dimeric GPVI) and have characterized their ability to bind recombinant GPVI, resting and ...
Joanne C. Clark, Ying Di, Natalie S. Poulter, Jonas Emsley, Jonas Emsley, Natalie J Jooss, Natalie J Jooss, Eleyna M. Martin, Mark R Thomas, Andrew B. Herr, Robert A. S. Ariëns, Fawaz Obaidullah Alenazy, Stephen P. Watson, Alexandre Slater   +13 more
openaire   +4 more sources

Preparation of cold-stored platelets on-demand: A novel approach to inventory management. [PDF]

Transfusion
Abstract Background Cold‐stored platelets (CSP) are now being used to treat acute bleeding. However, as CSP are less suitable for prophylaxis, both room temperature (RT) platelets and CSP will be required, which complicates inventory management. The production of CSP “on‐demand” from RT platelets may be a desirable option.
Johnson L, Waters L, Roan C, Lei P, Mahajan J, Portier M, Winskel-Wood B, Marks DC.   +7 more
europepmc   +2 more sources

mTOR regulates GPVI-mediated platelet activation [PDF]

Journal of Translational Medicine, 2021
Abstract Background Due to mTOR (mammalian/mechanistic target of rapamycin) gene-loss mice die during embryonic development, the role of mTOR in platelets has not been evaluated using gene knockout technology. Methods A mouse model with megakaryocyte/platelet-specific ...
Longsheng Wang, Weihong Xu, Nannan Wu, Shuang Han, Qiaoyun Liu, Cunji Gao, Cunji Gao, Baiyun Dai, Zhihua Chen, Dajing Xia, Gang Liu, Fang Huang   +11 more
openaire   +4 more sources

Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation

Thrombosis and Haemostasis, 2021
AbstractCollagen has been proposed to bind to a unique epitope in dimeric glycoprotein VI (GPVI) and the number of GPVI dimers has been reported to increase upon platelet activation. However, in contrast, the crystal structure of GPVI in complex with collagen-related peptide (CRP) showed binding distinct from the site of dimerization.
Mark Soave, Bernhard Nieswandt, Stephen J. Hill, Dirk-Peter Herten, Dirk-Peter Herten, Dirk-Peter Herten, Alexandre Slater, Eleyna M. Martin, Joanne C. Clark, Joanne C. Clark, David Stegner, Raluca A. I. Neagoe, Raluca A. I. Neagoe, Malou Zuidscherwoude, Malou Zuidscherwoude, Michael G. Tomlinson, Michael G. Tomlinson, Johan Hummert, Johan Hummert, Johan Hummert, Deirdre M. Kavanagh, Deirdre M. Kavanagh, Natalie S. Poulter, Natalie S. Poulter, Steve P. Watson, Steve P. Watson   +25 more
openaire   +4 more sources

In Vitro Comparison of Device-Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps. [PDF]

Artif Organs
This in vitro comparative study demonstrated that the HeartMate 3 pump has a superior overall hemocompatibility profile to the HeartMate 2 pump, underscoring the advantages of the maglev centrifugal pump design compared to the axial pump design. ABSTRACT Background Left ventricular assist devices (LVADs) have been utilized to maintain the circulatory ...
Vandenberge J, Han D, Sun W, Wang S, Tran D, Kim N, Clark K, Perez R, Griffith BP, Wu ZJ.   +9 more
europepmc   +2 more sources

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI [PDF]

Blood Advances, 2018
Key Points Soluble GPVI is elevated in patients with thermal injury with sepsis, and sGPVI levels augment severity score prediction of mortality.
Tariq Iqbal, Christine Lee, Samantha J. Montague, Samantha J. Montague, Nathalie Layios, Robert K. Andrews, Chris Gardiner, Naiem Moiemen, Christelle Lecut, Paul Harrison, Paul Harrison, Amy Bamford, Natalie S. Poulter, Natalie S. Poulter, Christopher M. Wearn, Christopher M. Wearn, Céline Delierneux, Jonathan R B Bishop, Robert J. Dinsdale, Robert J. Dinsdale, Peter Hampson, Peter Hampson, Woei Ming Lee, Elizabeth E. Gardiner, Nathalie Maes, Cécile Oury, Steve P. Watson, Steve P. Watson   +27 more
openaire   +6 more sources