Platelet glycoprotein VI promotes folic acid-induced acute kidney injury through interaction with tubular epithelial cell-derived galectin-3 [PDF]
Cell Communication and SignalingBackground Acute kidney injury (AKI) is defined by a significant reduction in renal function, which subsequently impairs coagulation and activates the inflammatory immune response, ultimately resulting in damage to renal tubular epithelial cells (TECs ...
Ya-Wei Guo +8 more
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Association of polymorphisms of platelet receptors GPIa (807C>T), GPVI (13254T>C), and P2Y12 (34C>T and H1/H2 haplotype) with increased risk of periprocedural bleeding in patients undergoing coronary angiography/percutaneous coronary intervention [PDF]
Advances in Interventional Cardiology, 2017 Introduction: Periprocedural bleeding related to coronary angiography (CAG) or percutaneous coronary intervention (PCI) is associated with worse prognosis. Determining genetic variations associated with increased bleeding risk may help to identify high-
Magdalena Sionova +5 more
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Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel
Platelets, 2022 The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing ...
Marie-Astrid van Dievoet +4 more
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Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
Platelets, 2019 GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain.
Alexandre Slater +8 more
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Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2
Platelets, 2021 GPVI and CLEC-2 have emerged as promising targets for long-term prevention of both arterial thrombosis and thrombo-inflammation with a decreased bleeding risk relative to current drugs.
Foteini-Nafsika Damaskinaki +4 more
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Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Platelets, 2021 Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi +4 more
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Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets [PDF]
International Journal of Molecular Sciences, 2023 Bruton’s tyrosine kinase (Btk) and spleen tyrosine kinase (Syk) are major signaling proteins in human platelets that are implicated in atherothrombosis and thrombo-inflammation, but the mechanisms controlling their activities are not well understood ...
Pengyu Zhang +6 more
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Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease [PDF]
Frontiers in Cardiovascular Medicine, 2023 Colchicine has been demonstrated to reduce cardiovascular death, myocardial infarction (MI), ischemic stroke, and ischemia-driven coronary revascularization in people with coronary artery disease (CAD).
Gabrielle J. Pennings +4 more
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Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs [PDF]
Blood, 2020 Platelets engage cues of pending vascular injury through coordinated adhesion, secretion and aggregation responses. These rapid, progressive changes in platelet form and function are orchestrated downstream of specific receptors on the platelet cell ...
Özgün Babur +16 more
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Journal of Nuclear Medicine, 2023 Visual Abstract Invariably fatal and with a particularly fast progression, pulmonary fibrosis (PF) is currently devoid of curative treatment options. Routine clinical diagnosis relies on breathing tests and visualizing the changes in lung structure by CT,
Simon Isser +8 more
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