Results 41 to 50 of about 6,202 (185)

Glenzocimab: A GPVI (Glycoprotein VI)-Targeted Potential Antiplatelet Agent for the Treatment of Acute Ischemic Stroke.

Stroke, 2022
It has previously been shown in several animal experiments that platelet GPVI (glycoprotein VI) contributes to thrombosis, particularly in ischemic stroke. Moreover, GPVI levels are upregulated in stroke patients.
Surasak Wichaiyo, W. Parichatikanond, Wipharak Rattanavipanon   +2 more
semanticscholar   +1 more source

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI

Blood, 2022
Kaiser et al investigated how platelets contribute to vascular integrity during inflammation. They show that single migrating platelets become procoagulant, recruiting the coagulation cascade to prevent pulmonary inflammatory bleeding.
R. Kaiser, Raphael Escaig, J. Kranich, Marie Hoffknecht, Afra Anjum, Vivien Polewka, Magdalena Mader, Wenbo Hu, Larissa Belz, C. Gold, A. Titova, M. Lorenz, Kami Pekayvaz, S. Kääb, Florian Gaertner, K. Stark, T. Brocker, S. Massberg, Leo Nicolai   +18 more
semanticscholar   +1 more source

Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System

Arteriosclerosis, Thrombosis and Vascular Biology, 2021
The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on megakaryocytes and platelets and is currently recognized as a receptor for not only collagen but also a variety of plasma and vascular proteins, including fibrin, fibrinogen ...
G. Perrella, M. Nagy, Steve P. Watson, Johan W. M. Heemskerk   +3 more
semanticscholar   +1 more source

GPVI expression is linked to platelet size, age, and reactivity

Blood Advances, 2022
Key Points Juvenile platelets show increased GPVI expression. These platelets are highly responsive and more abundant among large platelets.
Alicia Veninga, S. Handtke, K. Aurich, B. Tullemans, S. Brouns, S. L. Schwarz, F. Heubel-Moenen, A. Greinacher, J. Heemskerk, P. V. D. van der Meijden, T. Thiele   +10 more
semanticscholar   +1 more source

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation

JACC: Basic to Translational Science, 2016
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc.
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD   +14 more
doaj   +1 more source

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Bleeding, Thrombosis and Vascular Biology, 2023
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García   +5 more
doaj   +1 more source

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation

Journal of Thrombosis and Haemostasis, 2022
The collagen receptor glycoprotein VI (GPVI) is an attractive antiplatelet target due to its critical role in thrombosis but minor involvement in hemostasis.
Natalie J. Jooss, Christopher W Smith, Alexandre Slater, S. Montague, Ying Di, C. O’Shea, Mark R Thomas, Y. Henskens, J. Heemskerk, S. Watson, Natalie S. Poulter   +10 more
semanticscholar   +1 more source

Collagen-dependent platelet dysfunction and its relevance to either mitochondrial ROS or cytosolic superoxide generation: a question about the quality and functional competence of long-stored platelets

Thrombosis Journal, 2020
Background Upon vascular damage, the exposed subendothelial matrix recruits circulating platelets to site of injury while inducing their firm adhesion mainly via GPVI-collagen interaction.
Ehteramolsadat Hosseini, Saba Hojjati, Safoora Afzalniaye gashti, Mehran Ghasemzadeh   +3 more
doaj   +1 more source

Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ.

Blood Advances, 2021
There is increasing evidence that platelets participate in multiple pathophysiological processes other than thrombosis and hemostasis, such as immunity, inflammation, embryonic development, and cancer progression. A recent study revealed that heme (hemin)
Saori Oishi, N. Tsukiji, S. Otake, Naoki Oishi, Tomoyuki Sasaki, Toshiaki Shirai, Yuri Yoshikawa, Katsuhiro Takano, H. Shinmori, T. Inukai, T. Kondo, K. Suzuki-Inoue   +11 more
semanticscholar   +1 more source

Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function.

American Journal of Physiology - Cell Physiology, 2021
Spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating ITAM-mediated signaling downstream of platelet glycoprotein VI (GPVI) and GPIIb/IIIa receptors.
Tony J. Zheng, Elizabeth R Lofurno, Alexander Melrose, H. Lakshmanan, J. Pang, K. Phillips, Meghan E. Fallon, T. Kohs, A. Ngo, J. Shatzel, M. Hinds, O. McCarty, J. Aslan   +12 more
semanticscholar   +1 more source