Results 41 to 50 of about 8,801 (259)

A key role for platelet GPVI in neutrophil recruitment, migration and NETosis in the early stages of acute lung injury.

Blood, 2023
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Excessive neutrophil infiltration into the pulmonary airspace is the main cause for the acute inflammation and lung injury. Platelets
Philipp Burkard, Charlotte Schonhart, T. Vögtle, D. Köhler, Linyan Tang, Denise Johnson, K. Hemmen, K. Heinze, A. Zarbock, H. Hermanns, P. Rosenberger, B. Nieswandt   +11 more
semanticscholar   +1 more source

Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets

Biomedicines, 2023
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic
Chao Han, Pengxuan Ren, Medina Mamtimin, Linus Kruk, Edita Sarukhanyan, Chenyu Li, Hans-Joachim Anders, Thomas Dandekar, Irena Krueger, Margitta Elvers, Silvia Goebel, Kristin Adler, Götz Münch, Thomas Gudermann, Attila Braun, Elmina Mammadova-Bach   +15 more
doaj   +1 more source

Functional characterization of a nanobody based GPVI specific platelet agonist [PDF]

Res Pract Thromb Haemost
Minka Živkovic, Elisabeth Pols-van Veen, Vossa van der Vegte, Silvie Sebastian, Annick S de Moor, Suzanne J.A. Korporaal, Roger E. G. Schutgens, Rolf T. Urbanus   +7 more
openalex   +2 more sources

Bioactive food components and their inhibitory actions in multiple platelet pathways

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described. Abstract In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis ...
Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy   +7 more
wiley   +1 more source

Oroxylin A reverses SHP-2 oxidative inactivation in GPVI signaling to suppress platelet activation and thrombus formation [PDF]

Thromb J
Yufei Chen, Yuan Lin, Jin Tae Hong, Jiaorui Wang, B Li, Zixian Liu, Yongbo Ma, Sun Xiao-lan, Shufang Wang, Mingjie Li, Meiling Wu, Deyu Fu, Jian Li, Mingzhu Wang, Liang Hu   +14 more
openalex   +2 more sources

Platelet glycoprotein VI in the regulation of thrombus growth [PDF]

, 2022
Platelet glycoprotein VI (GPVI) is the principal signalling receptor for collagen, which is exposed upon damage to the extracellular matrix and at site of rupture of an atherosclerotic plaque.
Perrella, Gina
core   +2 more sources

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI [PDF]

Blood Advances, 2018
Key Points Soluble GPVI is elevated in patients with thermal injury with sepsis, and sGPVI levels augment severity score prediction of mortality.
Tariq Iqbal, Christine Lee, Samantha J. Montague, Samantha J. Montague, Nathalie Layios, Robert K. Andrews, Chris Gardiner, Naiem Moiemen, Christelle Lecut, Paul Harrison, Paul Harrison, Amy Bamford, Natalie S. Poulter, Natalie S. Poulter, Christopher M. Wearn, Christopher M. Wearn, Céline Delierneux, Jonathan R B Bishop, Robert J. Dinsdale, Robert J. Dinsdale, Peter Hampson, Peter Hampson, Woei Ming Lee, Elizabeth E. Gardiner, Nathalie Maes, Cécile Oury, Steve P. Watson, Steve P. Watson   +27 more
openaire   +6 more sources

Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny

Pharmaceutics, 2023
Antisense oligonucleotide (ASO) is a therapeutic modality that enables selective modulation of undruggable protein targets. However, dose- and sequence-dependent platelet count reductions have been reported in nonclinical studies and clinical trials. The
Allan Valenzuela, M. Ayuso, Laura Buyssens, Chloé Bars, C. Van Ginneken, Y. Tessier, S. V. Van Cruchten   +6 more
semanticscholar   +1 more source

Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. [PDF]

PLoS ONE, 2014
We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation.
Naadiya Carrim, Tony G Walsh, Alessandra Consonni, Mauro Torti, Michael C Berndt, Pat Metharom   +5 more
doaj   +1 more source

Glenzocimab: A GPVI (Glycoprotein VI)-Targeted Potential Antiplatelet Agent for the Treatment of Acute Ischemic Stroke.

Stroke, 2022
It has previously been shown in several animal experiments that platelet GPVI (glycoprotein VI) contributes to thrombosis, particularly in ischemic stroke. Moreover, GPVI levels are upregulated in stroke patients.
Surasak Wichaiyo, W. Parichatikanond, Wipharak Rattanavipanon   +2 more
semanticscholar   +1 more source