Results 51 to 60 of about 8,801 (259)

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition

Blood Advances, 2022
Key Points • Crystallization studies map the binding of glenzocimab to the site of dimerization in the D2 domain of GPVI.• Glenzocimab inhibits GPVI interactions with CRP, collagen, and fibrin by loss of dimerization, conformational changes, and steric ...
P. Billiald, Alexandre Slater, M. Welin, Joanne C. Clark, Loyau Stéphane, M. Pugnière, I. Jiacomini, Nadia Rose, Kristell Lebozec, Elie Toledano, Déborah François, S. Watson, M. Jandrot-Perrus   +12 more
semanticscholar   +1 more source

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI

Blood, 2022
Kaiser et al investigated how platelets contribute to vascular integrity during inflammation. They show that single migrating platelets become procoagulant, recruiting the coagulation cascade to prevent pulmonary inflammatory bleeding.
R. Kaiser, Raphael Escaig, J. Kranich, Marie Hoffknecht, Afra Anjum, Vivien Polewka, Magdalena Mader, Wenbo Hu, Larissa Belz, C. Gold, A. Titova, M. Lorenz, Kami Pekayvaz, S. Kääb, Florian Gaertner, K. Stark, T. Brocker, S. Massberg, Leo Nicolai   +18 more
semanticscholar   +1 more source

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets [PDF]

Journal of Thrombosis and Haemostasis, 2017
Essentials - Dimeric high-affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. - Spatio-temporal organization of platelet GPVI-dimers was evaluated using advanced microscopy. - Upon platelet adhesion to collagenous substrates, GPVI-dimers coalesce to form clusters.
Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.   +11 more
openaire   +6 more sources

Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency

Platelets, 2021
Acquired deficiencies in platelet glycoprotein VI are rare and have not been found associated with other defects. Here we report the case of a 64-year old male patient presenting an immune GPVI deficiency associated to a mutation in the alpha-actinin ...
Stéphane Loyau Inserm, Dorothée Faille, Philippe Gautier, Paquita Nurden, Martine Jandrot-Perrus, Nadine Ajzenberg   +5 more
doaj   +1 more source

Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Platelets, 2023
The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI ...
Stéphane Loyau, Anne Bauters, Nathalie Trillot, Cédric Garcia, Pierre Cougoul, Hélène Pol, Camille Paris, Geoffroy Robin, Chrystèle Rubod, Bernard Payrastre, Martine Jandrot-Perrus, Sophie Voisin, Annabelle Dupont   +12 more
doaj   +1 more source

The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors

International Journal of Molecular Sciences, 2022
The platelet-activating collagen receptor GPVI represents the focus of clinical trials as an antiplatelet target for arterial thrombosis, and soluble GPVI is a plasma biomarker for several human diseases.
C. Z. Koo, A. Matthews, Neale J Harrison, Justyna Szyroka, B. Nieswandt, E. Gardiner, Natalie S. Poulter, M. Tomlinson   +7 more
semanticscholar   +1 more source

Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear

International Journal of Molecular Sciences, 2022
Glycoprotein (GP)VI and integrin αIIbβ3 are key signaling receptors in collagen-dependent platelet aggregation and in arterial thrombus formation under shear. The multiple downstream signaling pathways are still poorly understood.
Jingnan Huang, Natalie J. Jooss, D. Fernández, A. Sickmann, Ángel García, K. Wichapong, I. Dijkgraaf, J. Heemskerk   +7 more
semanticscholar   +1 more source

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 [PDF]

, 2008
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet ...
Barrow, Bijsterbosch, Blake, Braselmann, Burkhardt, Chen, Christou, Cicmil, Clemetson, Daeron, de Vet, Deindl, Dhanjal, Eble, Ezumi, Fuller, Garcia, Gibbins, Grande, Inazu, Isnardi, Jones, Keren, Lerea, Maeda, Monroe, Moroi, Muraille, Newland, Newton, Nieswandt, Nieswandt, Ono, Patil, Poole, Quek, Ravetch, Reedquist, Roose, Senis, Shapiro, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Takata, Tomlinson, van Oers, Verbrugge, Vivier, Washington, Washington, Watson   +51 more
core   +3 more sources

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

International Journal of Molecular Sciences, 2022
Glycoprotein (GP) VI is the major platelet collagen receptor and a promising anti-thrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the Collagen-Related Peptide (CRP)-binding site on ...
Stefano Navarro, A. Starke, J. Heemskerk, Marijke J. E. Kuijpers, David Stegner, B. Nieswandt   +5 more
semanticscholar   +1 more source

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]

, 2009
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian, Alexandra Mazharian, Arias-Salgado, Arias-Salgado, Arthur Weiss, Asselin, Auger, Avecilla, Baker, Best, Best, Cheli, Choudhuri, Dhanjal, Dorahy, Dubois, Ezumi, Gibbins, Gibbins, Harper, Hermiston, Holsinger, Jenson Lim, Jing W. Zhu, Jocelyn M. Auger, Kalia, Kato, Klages, Kovalenko, Kralisz, Kristin N. Kornerup, Le Pera, Lin, Lin, Liu, Mangin, McCarty, McNeill, Michael G. Tomlinson, Minuz, Moarefi, Mocsai, Morton, Neena Kalia, Nonne, Obergfell, Palka, Park, Pasquet, Pasquet, Pasquet, Pearce, Poole, Quek, Senis, Snell, Somani, Sorby, Steve G. Thomas, Steve P. Watson, Stuart Ellison, Superti-Furga, Suzuki-Inoue, Suzuki-Inoue, Tarvinder Dhanjal, Tsuboi, Vandendries, Wagner, Watanabe, Watson, Wonerow, Woodside, Xu, Xu, Yamaguchi, Yan Zhao, Yotis A. Senis, Young, Zhang, Zhu   +79 more
core   +2 more sources