Results 51 to 60 of about 8,521 (239)

MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. [PDF]

, 2018
BACKGROUND: Acute thrombotic syndromes lead to atherosclerotic plaque rupture with subsequent thrombus formation, myocardial infarction and stroke. Following rupture, flowing blood is exposed to plaque components, including collagen, which triggers ...
Farndale, Richard W, Hamaia, Samir W, Howes, Joanna-Marie, Jung, Stephanie M, Knäuper, Vera, Malcor, Jean-Daniel, Pugh, Nicholas   +6 more
core   +4 more sources

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice

Haematologica, 2020
Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2.
Nathan Eaton, Caleb Drew, Jon Wieser, Adam D. Munday, Hervé Falet   +4 more
doaj   +1 more source

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation [PDF]

, 2019
Background Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of sub cellular interactions and as part
Bye, Alexander P., Di, Ying, Dunster, Joanne L., García, Ángel, Gibbins, Jonathan M., Haining, Elizabeth J,, Hardy, Alexander T., Nieswandt, Bernhard, Pallini, Chiara, Pike, Jeremy A., Pollitt, Alice Y., Poulter, Natalie S., Sage, Tanya, Sowa, Marcin A., Unsworth, Amanda J., Watson, Steve P.   +15 more
core   +3 more sources

Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation [PDF]

, 2008
The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined.
Altmann, Berid, Dlugai, Silke, Engelmann, Bernd, Grahl, Lenka, Hess, Sonja, Konrad, Aldiko, Lorenz, Michael, Mackman, Nigel, Manukyan, Davit, Massberg, Steffen, Orschiedt, Lena, Reinhardt, Christoph, Ruddock, Lloyd, von Brühl, Marie Luise   +13 more
core   +3 more sources

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells [PDF]

, 2010
Background: Platelet activation by collagen depends on signals transduced by the glycoprotein (GP)VI–Fc receptor (FcR)-chain collagen receptor complex, which involves recruitment of phosphatidylinositol 3-kinase (PI3K) to phosphorylated tyrosines in the ...
Barrett, Natasha Elizabeth, Gibbins, Jonathan Martin, Holbrook, L. M., Jones, Chris, Moraes, Leonardo Augusto, Newman, D. K., Sage, Tanya, Spyridon, M.   +7 more
core   +2 more sources

Targeting GPVI as a novel antithrombotic strategy

Journal of Blood Medicine, 2014
While platelet activation is essential to maintain blood vessel patency and minimize loss of blood upon injury, untimely or excessive activity can lead to unwanted platelet activation and aggregation. Resultant thrombosis has the potential to block blood vessels, causing myocardial infarction or stroke. To tackle this major cause of mortality, clinical
Andrews, Robert K, Arthur, JF, Gardiner, Elizabeth   +2 more
openaire   +6 more sources

Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function

Platelets, 2022
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo, Alexander R. Melrose, Jiaqing Pang, Hari Hara Sudhan Lakshmanan, Stéphanie E. Reitsma, Sai Hitesh Vavilapalli, Mark K. Larson, Joseph J. Shatzel, Owen J. T. McCarty, Joseph E. Aslan   +9 more
doaj   +1 more source

GPVI and CLEC‐2 in hemostasis and vascular integrity [PDF]

Journal of Thrombosis and Haemostasis, 2010
The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an immunoreceptor tyrosine-based activation motif (ITAM)-regulated signaling pathway. ITAMs are characterized by two YxxL sequences separated by 6-12 amino acids and are found associated with ...
Steve P. Watson, John Herbert, Alice Y. Pollitt   +2 more
openaire   +3 more sources

Regulation of platelet activation and thrombus formation by reactive oxygen species

Redox Biology, 2018
Reactive oxygen species (ROS) are generated within activated platelets and play an important role in regulating platelet responses to collagen and collagen-mediated thrombus formation.
Jianlin Qiao, Jane F. Arthur, Elizabeth E. Gardiner, Robert K. Andrews, Lingyu Zeng, Kailin Xu   +5 more
doaj   +1 more source

GPVI inhibitor as antitumor gateway drug [PDF]

Blood, 2019
In this issue of Blood, Volz et al establish a potential antitumor strategy by exploiting the selective requirement for platelets to maintain vascular integrity within the tumor microenvironment.1 Their work demonstrates, for the first time, that functional inhibition of platelet-specific surface receptor glycoprotein (GP) VI, using F(ab′)2 fragments ...
openaire   +3 more sources