Results 51 to 60 of about 6,202 (185)

Storage temperature determines platelet GPVI levels and function in mice and humans.

Blood Advances, 2021
Platelets are currently stored at room temperature before transfusion to maximize circulation time. This approach has numerous downsides, including limited storage duration, bacterial growth risk, and increased costs.
Jeffrey Miles, S. Bailey, Ava M. Obenaus, Molly Y. Mollica, Chomkan Usaneerungrueng, D. Byrne, Lydia Y Fang, Jake R Flynn, J. Corson, Barbara Osborne, Katie L. Houck, Yi Wang, Yu-Jia Shen, Xiaoyun Fu, Jing-fei Dong, N. Sniadecki, M. Stolla   +16 more
semanticscholar   +1 more source

ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies.
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer   +14 more
doaj   +1 more source

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation

Platelets, 2017
The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane proteins with which they interact.
Elizabeth J. Haining, Alexandra L. Matthews, Peter J. Noy, Hanna M. Romanska, Helen J. Harris, Jeremy Pike, Martina Morowski, Rebecca L. Gavin, Jing Yang, Pierre-Emmanuel Milhiet, Fedor Berditchevski, Bernhard Nieswandt, Natalie S. Poulter, Steve P. Watson, Michael G. Tomlinson   +14 more
doaj   +1 more source

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

International Journal of Molecular Sciences, 2022
Glycoprotein (GP) VI is the major platelet collagen receptor and a promising anti-thrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the Collagen-Related Peptide (CRP)-binding site on ...
Stefano Navarro, A. Starke, J. Heemskerk, Marijke J. E. Kuijpers, David Stegner, B. Nieswandt   +5 more
semanticscholar   +1 more source

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.

PLoS ONE, 2014
ObjectivePlatelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models.
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter   +7 more
doaj   +1 more source

Acquired platelet GPVI receptor dysfunction in critically-ill patients with sepsis.

Blood, 2021
GPVI, the platelet immunoreceptor tyrosine activating motif (ITAM) receptor for collagen plays a striking role on vascular integrity in animal models of inflammation and sepsis.
L. Weiss, G. Manukjan, A. Pflug, Nadine Winter, M. Weigel, Nils Nagler, M. Kredel, Thiên-Trí Lâm, B. Nieswandt, D. Weismann, H. Schulze   +10 more
semanticscholar   +1 more source

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice

Haematologica, 2020
Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2.
Nathan Eaton, Caleb Drew, Jon Wieser, Adam D. Munday, Hervé Falet   +4 more
doaj   +1 more source

Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear

International Journal of Molecular Sciences, 2022
Glycoprotein (GP)VI and integrin αIIbβ3 are key signaling receptors in collagen-dependent platelet aggregation and in arterial thrombus formation under shear. The multiple downstream signaling pathways are still poorly understood.
Jingnan Huang, Natalie J. Jooss, D. Fernández, A. Sickmann, Ángel García, K. Wichapong, I. Dijkgraaf, J. Heemskerk   +7 more
semanticscholar   +1 more source

Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function

Platelets, 2022
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo, Alexander R. Melrose, Jiaqing Pang, Hari Hara Sudhan Lakshmanan, Stéphanie E. Reitsma, Sai Hitesh Vavilapalli, Mark K. Larson, Joseph J. Shatzel, Owen J. T. McCarty, Joseph E. Aslan   +9 more
doaj   +1 more source

Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer.

Blood, 2021
GPVI is the major signalling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 (CDR3) loops, against recombinant GPVI-Fc (dimeric GPVI) and have ...
Alexandre Slater, Ying Di, Joanne C. Clark, Natalie J. Jooss, Eleyna M. Martin, F. Alenazy, Mark R Thomas, R. Ariëns, A. Herr, Natalie S. Poulter, J. Emsley, S. Watson   +11 more
semanticscholar   +1 more source