Results 61 to 70 of about 8,521 (239)

GPVI and integrin αIIbβ3 signaling in platelets [PDF]

Journal of Thrombosis and Haemostasis, 2005
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alphaIIb beta3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to
Steve P. Watson, Andrew C. Pearce, Jocelyn M. Auger, Owen J. T. McCarty   +3 more
openaire   +3 more sources

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

Platelets, 2021
Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi, Christopher W. Smith, Phillip L. R. Nicolson, Steve P. Watson, Mark R. Thomas   +4 more
doaj   +1 more source

Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer. [PDF]

Blood Adv
Abstract Glycoprotein VI (GPVI) plays a key role in collagen-induced platelet aggregation. Affimers are engineered binding protein alternatives to antibodies. We screened and characterized GPVI-binding Affimers as novel tools to probe GPVI function.
Xu RG, Tiede C, Calabrese AN, Cheah LT, Adams TL, Gauer JS, Hindle MS, Webb BA, Yates DM, Slater A, Duval C, Naseem KM, Herr AB, Tomlinson DC, Watson SP, Ariëns RAS.   +15 more
europepmc   +3 more sources

Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency [PDF]

Journal of Thrombosis and Haemostasis, 2009
Glycoprotein (GP)VI deficiency is a rare platelet disorder with a mild bleeding tendency. However, its pathophysiology remains unclear.We characterized a novel GPVI-deficient patient with immune thrombocytopenic purpura and searched for the presence of anti-GPVI autoantibodies in this and another patient with GPVI deficiency.A 12-year-old Japanese girl
Akiyama, M., Kashiwagi, H., Todo, K., Moroi, M., Berndt, Michael, Kojima, H., Kanakura, Y., Tomiyama, Y.   +7 more
openaire   +4 more sources

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis

Frontiers in Pharmacology, 2023
Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation in vitro and explored the effect of luteolin on thrombosis ...
Yujia Ye, Lihong Yang, Min Leng, Qian Wang, Jiankui Wu, Wen Wan, Huawei Wang, Longjun Li, Yunzhu Peng, Shengjie Chai, Zhaohui Meng   +10 more
doaj   +1 more source

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

Platelet glycoprotein VI genetic quantitative and qualitative defects

Platelets, 2019
Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for ...
Martine Jandrot-Perrus, Cedric Hermans, Diego Mezzano   +2 more
doaj   +1 more source

Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel

Platelets, 2022
The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing ...
Marie-Astrid van Dievoet, Davide Brusa, Marie Octave, Sandrine Horman, Xavier Stephenne   +4 more
doaj   +1 more source

Platelet GPVI repairs its own damage [PDF]

Blood, 2015
In this issue of Blood, Gros et al report that glycoprotein VI (GPVI) promotes the proinflammatory role of platelets by increasing neutrophil secretion and toxicity while at the same time repairing the vascular damage inflicted by neutrophil activation, thereby maintaining vascular integrity. Significantly, this effect is independent of hemostasis.
Julie Rayes, Steve P. Watson
openaire   +3 more sources

Fibrin activates GPVI in human and mouse platelets [PDF]

Blood, 2015
Key PointsFibrin is a novel ligand for the platelet collagen receptor, GPVI, increasing platelet procoagulant activity. Activation of GPVI by fibrin contributes to thrombus growth and stabilization.
Jonathan Frampton, Markus Bender, Craig E. Hughes, Stephanie Watson, Steve P. Watson, Osama Alshehri, Samantha J. Montague   +6 more
openaire   +2 more sources