Results 61 to 70 of about 6,202 (185)
Regulation of platelet activation and thrombus formation by reactive oxygen species
Redox Biology, 2018 Reactive oxygen species (ROS) are generated within activated platelets and play an important role in regulating platelet responses to collagen and collagen-mediated thrombus formation.
Jianlin Qiao +5 more
doaj +1 more source
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Platelets, 2021 Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi +4 more
doaj +1 more source
A Comparative Assessment Study of Known Small-molecule GPVI Modulators.
ACS Medicinal Chemistry Letters, 2022 The GPVI platelet receptor was recently validated as a safe antiplatelet target for the treatment of thrombosis using several peptidic modulators. In contrast, few weakly potent small-molecule GPVI antagonists have been reported.
Holly Foster +10 more
semanticscholar +1 more source
Platelet glycoprotein VI genetic quantitative and qualitative defects
Platelets, 2019 Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for ...
Martine Jandrot-Perrus +2 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2021 Background The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet ...
Muhammad Usman Ahmed +8 more
doaj +1 more source
Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, Accepted Article.Background ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. Objective To evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired thrombo‐inflammatory ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
Platelets, 2019 GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain.
Alexandre Slater +8 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source
TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation
The FEBS Journal, EarlyView.TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni +7 more
wiley +1 more source
Journal of Thrombosis and Thrombolysis, 2022 Background Platelet glycoprotein VI (GPVI) receptor is essential for platelet adhesion and aggregation. Eltrombopag is as an effective treatment for chronic immune thrombocytopenia (ITP); yet, its effect on platelet function is not fully characterized ...
A. Tantawy +6 more
semanticscholar +1 more source