Results 71 to 80 of about 8,801 (259)

Evaluation of the effect of eltrombopag therapy on the platelet collagen receptor glycoprotein VI (GPVI) expression and soluble GPVI levels in young patients with immune thrombocytopenia

Journal of Thrombosis and Thrombolysis, 2022
Background Platelet glycoprotein VI (GPVI) receptor is essential for platelet adhesion and aggregation. Eltrombopag is as an effective treatment for chronic immune thrombocytopenia (ITP); yet, its effect on platelet function is not fully characterized ...
A. Tantawy, N. Elsherif, F. Ebeid, R. El-Gamal, E. Ismail, M. Kenny, Michael Botros Elkes morcos   +6 more
semanticscholar   +1 more source

Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ.

Blood Advances, 2021
There is increasing evidence that platelets participate in multiple pathophysiological processes other than thrombosis and hemostasis, such as immunity, inflammation, embryonic development, and cancer progression. A recent study revealed that heme (hemin)
Saori Oishi, N. Tsukiji, S. Otake, Naoki Oishi, Tomoyuki Sasaki, Toshiaki Shirai, Yuri Yoshikawa, Katsuhiro Takano, H. Shinmori, T. Inukai, T. Kondo, K. Suzuki-Inoue   +11 more
semanticscholar   +1 more source

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.

PLoS ONE, 2014
ObjectivePlatelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models.
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter   +7 more
doaj   +1 more source

Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation [PDF]

, 2008
The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined.
Altmann, Berid, Dlugai, Silke, Engelmann, Bernd, Grahl, Lenka, Hess, Sonja, Konrad, Aldiko, Lorenz, Michael, Mackman, Nigel, Manukyan, Davit, Massberg, Steffen, Orschiedt, Lena, Reinhardt, Christoph, Ruddock, Lloyd, von Brühl, Marie Luise   +13 more
core   +3 more sources

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1

International Journal of Molecular Sciences, 2022
Platelet and coagulation activation are highly reciprocal processes driven by multi-molecular interactions. Activated platelets secrete several coagulation factors and expose phosphatidylserine, which supports the activation of coagulation factor ...
Ilaria De Simone, C. Baaten, M. Jandrot-Perrus, J. Gibbins, H. ten Cate, J. Heemskerk, C. Jones, P. V. D. van der Meijden   +7 more
semanticscholar   +1 more source

Generative Particle Variational Inference via Estimation of Functional Gradients [PDF]

arXiv, 2021
Recently, particle-based variational inference (ParVI) methods have gained interest because they can avoid arbitrary parametric assumptions that are common in variational inference. However, many ParVI approaches do not allow arbitrary sampling from the posterior, and the few that do allow such sampling suffer from suboptimality.
arxiv  

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency [PDF]

Journal of Thrombosis and Haemostasis, 2009
Glycoprotein (GP)VI deficiency is a rare platelet disorder with a mild bleeding tendency. However, its pathophysiology remains unclear.We characterized a novel GPVI-deficient patient with immune thrombocytopenic purpura and searched for the presence of anti-GPVI autoantibodies in this and another patient with GPVI deficiency.A 12-year-old Japanese girl
Akiyama, M., Kashiwagi, H., Todo, K., Moroi, M., Berndt, Michael, Kojima, H., Kanakura, Y., Tomiyama, Y.   +7 more
openaire   +4 more sources

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation

Platelets, 2017
The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane proteins with which they interact.
Elizabeth J. Haining, Alexandra L. Matthews, Peter J. Noy, Hanna M. Romanska, Helen J. Harris, Jeremy Pike, Martina Morowski, Rebecca L. Gavin, Jing Yang, Pierre-Emmanuel Milhiet, Fedor Berditchevski, Bernhard Nieswandt, Natalie S. Poulter, Steve P. Watson, Michael G. Tomlinson   +14 more
doaj   +1 more source

Targeting GPVI as a novel antithrombotic strategy

Journal of Blood Medicine, 2014
While platelet activation is essential to maintain blood vessel patency and minimize loss of blood upon injury, untimely or excessive activity can lead to unwanted platelet activation and aggregation. Resultant thrombosis has the potential to block blood vessels, causing myocardial infarction or stroke. To tackle this major cause of mortality, clinical
Andrews, Robert K, Arthur, JF, Gardiner, Elizabeth   +2 more
openaire   +6 more sources