Results 71 to 80 of about 6,202 (185)

GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion

Platelets, 2017
Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation ...
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Fatemeh Nassaji, Zeynab Pirmohammad Jamaat   +3 more
doaj   +1 more source

Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets

Platelets, 2023
Alternate splicing is among the regulatory mechanisms imparting functional diversity in proteins. Studying protein isoforms generated through alternative splicing is therefore critical for understanding protein functions in many biological systems ...
Pankaj Kumar Singh, Carol A. Dangelmaier, Hymavathi Reddy Vari, Alexander Y. Tsygankov, Satya P. Kunapuli   +4 more
doaj   +1 more source

Retention of critical platelet hemostatic functions of amotosalen‐UVA pathogen‐reduced cryoprecipitated fibrinogen complex

Transfusion, EarlyView.
Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin, Clarisse Mouriaux, Michelle Gatmaitan, Kaja Kaastrup, Subramanian Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice

Haematologica, 2019
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes   +9 more
doaj   +1 more source

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan. [PDF]

PLoS ONE, 2015
Exposure of platelets to collagen triggers the formation of a platelet clot. Pharmacological agents capable of inhibiting platelet activation by collagen are thus of potential therapeutic interest.
Peng Jiang, Stéphane Loyau, Maria Tchitchinadze, Jacques Ropers, Guillaume Jondeau, Martine Jandrot-Perrus   +5 more
doaj   +1 more source

Computational Fluid Dynamic Analysis of Fluid Motion and Volumetric Gas–Liquid Mass Transfer in Agitated Platelet Concentrate Storage

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Platelets (PLTs) are small blood cells that play a vital role in stopping bleeding. After donation, they are stored in special bags, but their quality decreases over time. One reason for this decline is the mechanical stress they experience during collection, processing, and storage.
Dean Pym, Amanda J. Davies, Jessica O. Williams, Christine Saunders, Chloë E. George, Allan Mason‐Jones, Philip E. James   +6 more
wiley   +1 more source

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1

International Journal of Molecular Sciences, 2022
Platelet and coagulation activation are highly reciprocal processes driven by multi-molecular interactions. Activated platelets secrete several coagulation factors and expose phosphatidylserine, which supports the activation of coagulation factor ...
Ilaria De Simone, C. Baaten, M. Jandrot-Perrus, J. Gibbins, H. ten Cate, J. Heemskerk, C. Jones, P. V. D. van der Meijden   +7 more
semanticscholar   +1 more source

Discovery of novel GPVI receptor antagonists by structure-based repurposing.

PLoS ONE, 2014
Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug 'resistance', underpinning a drive for new antiplatelet ...
Lewis Taylor, Sridhar R Vasudevan, Chris I Jones, Jonathan M Gibbins, Grant C Churchill, R Duncan Campbell, Carmen H Coxon   +6 more
doaj   +1 more source

GPVI inhibition by glenzocimab synergistically inhibits atherosclerotic plaque-induced platelet activation when combined with conventional dual antiplatelet therapy [PDF]

, 2021
Fawaz O. Alenazy, Maan H. Harbi, Dean Kavanagh, Joshua Price, Paul Brady, O Hargreaves, Paul H. M. Harrison, Alexandre Slater, Derek Connolly, Paulus Kirchhof, Neena Kalia, Martine Jandrot‐Perrus, Pierre Mangin, Steve P. Watson, Mark R. Thomas   +14 more
openalex   +1 more source

Enhanced O2 availability in platelet concentrates stored for neonatal transfusion is independent of agitation: Evidence from direct oximetry and Fickian diffusion modelling

Vox Sanguinis, Volume 120, Issue 12, Page 1232-1241, December 2025.
Abstract Background and Objectives Platelet transfusions are essential for mitigating the bleeding risk of neonatal patients with thrombocytopenia. As neonatal patients have a small blood volume, adult therapeutic dose platelet units are split into reduced‐volume storage containers to maximize the use of the donated product and reduce donor exposure ...
Dean Pym, Oleg Grinberg, Amanda J. Davies, Jessica O. Williams, Christine Saunders, Chloë E. George, Philip E. James   +6 more
wiley   +1 more source