Results 71 to 80 of about 8,521 (239)

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib [PDF]

, 2017
The Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib induces platelet dysfunction and causes increased risk of bleeding. Off-target inhibition of Tec is believed to contribute to platelet dysfunction and other side-effects of ibrutinib.
Appleby, Niamh, Bruce, David, Bye, Alex P., Desborough, Michael J., Gibbins, Jon M., Hildyard, Catherine A. T., Hughes, Craig E., Kriek, Neline, Nock, Sophie H., Sage, Tanya, Unsworth, Amanda J.   +10 more
core   +2 more sources

Non-genomic effects of nuclear receptors: insights from the anucleate platelet [PDF]

, 2018
Nuclear receptors have the ability to elicit two different kinds of responses, genomic and non-genomic. While genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently of ...
Ahmadian, Ahuja, Ajayi, Ajjan, Akarasereenont, Akbiyik, Ali, Ali, Ali, Amanda J Unsworth, Badimon, Bain, Bar, Beckman, Bishop-Bailey, Bledsoe, Boilard, Boonyaratanakornkit, Borsig, Burris, Bye, Calkin, Campelo, Cecchetti, Cesario, Chinetti, Cumhur Cure, Dolle, Du, Duong, El Haouari, Evans, Falkenstein, Filippatos, Frye, Gabbi, Gagan D Flora, Ghasri, Güncü, Hammes, Hankey, Hellgren, Huang, Johnson, Johnson, Jonathan M Gibbins, Jones, Kadmiel, Kato, Kersten, Khan, Khetawat, Kiss, Krasowski, Kwon, Layton, Lee, Li, Liverani, Losel, Makishima, Matsuda, Maximov, McKenna, Mencarelli, Moraes, Moraes, Moraes, Moraes, Moraes, Morrell, Muchmore, Murphy, Nadal, Nathan, Ng, Njar, Noy, Ordóñez-Morán, Overington, Pilo, Richard, Risitano, Rondina, Rowley, Santilli, Sato, Schaffer, Schneider, Schubert, Schulz, Schwertz, Sepe, Sidhu, Silvagno, Spyridon, Sundahl, Trayhurn, Unsworth, Unsworth, Unsworth, Unsworth, Valera, Walmsley, Wang, Wu‐Wong, Wójcicka, Xu, Zimmerman   +108 more
core   +2 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets

Platelets, 2023
Alternate splicing is among the regulatory mechanisms imparting functional diversity in proteins. Studying protein isoforms generated through alternative splicing is therefore critical for understanding protein functions in many biological systems ...
Pankaj Kumar Singh, Carol A. Dangelmaier, Hymavathi Reddy Vari, Alexander Y. Tsygankov, Satya P. Kunapuli   +4 more
doaj   +1 more source

Platelet dysfunction in immune thrombocytopenia: Finding clinical subsets with platelet phenotypes

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) remain a challenge to diagnose, manage and predict bleeding risk. A comprehensive assessment of platelet function may aid clinical management. This study assessed platelet parameters to predict bleeding in ITP.
Sidra A. Ali, Sarah M. Hicks, Lucy A. Coupland, Simone A. Brysland, Vijay Bhoopalan, Yee Lin Thong, Amandeep Kaur, Robert K. Andrews, Elizabeth E. Gardiner, Philip Y.‐I. Choi   +9 more
wiley   +1 more source

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Platelets, 2019
GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain.
Alexandre Slater, Gina Perrella, Marie-Blanche Onselaer, Eleyna M Martin, Julia S Gauer, Rui-Gang Xu, Johan WM Heemskerk, Robert A S Ariëns, Steve P Watson   +8 more
doaj   +1 more source

TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation

The FEBS Journal, EarlyView.
TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni, Lucia Merolle, Agnese Razzoli, Eleonora Maurizi, Gaia Gavioli, Roberto Baricchi, Chiara Marraccini, Davide Schiroli   +7 more
wiley   +1 more source

Enhanced O2 availability in platelet concentrates stored for neonatal transfusion is independent of agitation: Evidence from direct oximetry and Fickian diffusion modelling

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Platelet transfusions are essential for mitigating the bleeding risk of neonatal patients with thrombocytopenia. As neonatal patients have a small blood volume, adult therapeutic dose platelet units are split into reduced‐volume storage containers to maximize the use of the donated product and reduce donor exposure ...
Dean Pym, Oleg Grinberg, Amanda J. Davies, Jessica O. Williams, Christine Saunders, Chloë E. George, Philip E. James   +6 more
wiley   +1 more source

GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion

Platelets, 2017
Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation ...
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Fatemeh Nassaji, Zeynab Pirmohammad Jamaat   +3 more
doaj   +1 more source

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

Research and Practice in Thrombosis and Haemostasis, 2021
Background The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet ...
Muhammad Usman Ahmed, Nicolas Receveur, Emily Janus‐Bell, Clarisse Mouriaux, Christian Gachet, Martine Jandrot‐Perrus, Béatrice Hechler, Elizabeth E. Gardiner, Pierre H. Mangin   +8 more
doaj   +1 more source