Results 81 to 90 of about 6,202 (185)
Platelets, 2017 Platelet membrane bedecked with a wide array of receptors offers a platform to regulate platelet responsiveness, thrombotic propensity, inflammatory disposition, and immune reactivity under diverse pathophysiological conditions.
Madhumita Chatterjee, Meinrad Gawaz
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High-throughput elucidation of thrombus formation reveals sources of platelet function variability
Haematologica, 2019 In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation.
Johanna P. van Geffen +19 more
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Advanced Science, Volume 12, Issue 41, November 6, 2025.Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu +16 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 20, 31 October 2025.Drug‐induced gingival overgrowth involves dysregulation of intracellular collagen degradation. The mechanisms that are involved in the regulation of lysosomal collagenolytic activity are poorly understood. Here, we focus on how cathepsins, Rabs, and V‐ATPases regulate intracellular collagen degradation and, in particular, the vesicular trafficking and ...
Wing Hei Wong +3 more
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Model systems for platelet receptor shedding
Platelets, 2017 Platelet adhesion and aggregation at sites of vascular injury are crucial for hemostasis; however, under pathological conditions, they can cause myocardial infarction and stroke.
Markus Bender +2 more
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Comparison of the GPVI inhibitors losartan and honokiol
Platelets, 2020 Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Marie-Blanche Onselaer +9 more
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Emerging Strategies for Platelet‐Modified Nanoparticles in Targeted Tumor Therapy
Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.This review highlights innovative strategies using platelet‐modified nanoparticles to target tumors more precisely. By mimicking platelet functions, these biomimetic carriers improve tumor homing, enhance drug delivery, and reduce immune clearance.
Chunyu Bai +5 more
wiley +1 more source
Basic mechanisms of platelet receptor shedding
Platelets, 2017 Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease.
Robert K. Andrews, Elizabeth E. Gardiner
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Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. [PDF]
PLoS ONE, 2015 Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms.
Yongwei Zheng +7 more
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The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence
Brain and Behavior, Volume 15, Issue 10, October 2025.This study delineates the multiple pathways leading to stroke, encompassing genetic risk factors such as lipid/cholesterol metabolism, blood pressure regulation genes, and endothelial dysfunction. The report includes genetic pathways such as Val66Met polymorphism, prothrombin G20210A, interleukin‐6 and tumor necrosis factor gene variant, along with ...
Mega Obukohwo Oyovwi +3 more
wiley +1 more source