Results 81 to 90 of about 8,801 (259)

Platelet GPVI repairs its own damage [PDF]

Blood, 2015
In this issue of Blood, Gros et al report that glycoprotein VI (GPVI) promotes the proinflammatory role of platelets by increasing neutrophil secretion and toxicity while at the same time repairing the vascular damage inflicted by neutrophil activation, thereby maintaining vascular integrity. Significantly, this effect is independent of hemostasis.
Julie Rayes, Steve P. Watson
openaire   +3 more sources

Immobilized fibrinogen activates human platelets through GPVI [PDF]

, 2018
GPVI, a major platelet activation receptor for collagen and fibrin, is considered as a particularly promising safe antithrombotic target. In this study, we show that human GPVI signals upon platelet adhesion to fibrinogen.
Ariens, Robert A., Babar, Amir K, Dupuis, Arnaud, Gachet, Christian, Hardy, Alexander T., Herr, Andrew B., Hughes, Craig E., Jandrot-Perrus, Martine, Le Lay, Nicolas, Loyau, Stephane, Mangin, Pierre H., Mezzano, Diego, Miller, Jeanette L. C., Onselaer, Marie-Blanche, Philippou, Helen, Receveur, Nicolas, Sanchez, Ximena, Watson, Steve P., Wilson, Clare   +18 more
core   +3 more sources

GPVI inhibitor as antitumor gateway drug [PDF]

Blood, 2019
In this issue of Blood, Volz et al establish a potential antitumor strategy by exploiting the selective requirement for platelets to maintain vascular integrity within the tumor microenvironment.1 Their work demonstrates, for the first time, that functional inhibition of platelet-specific surface receptor glycoprotein (GP) VI, using F(ab′)2 fragments ...
openaire   +3 more sources

Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function.

American Journal of Physiology - Cell Physiology, 2021
Spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating ITAM-mediated signaling downstream of platelet glycoprotein VI (GPVI) and GPIIb/IIIa receptors.
Tony J. Zheng, Elizabeth R Lofurno, Alexander Melrose, H. Lakshmanan, J. Pang, K. Phillips, Meghan E. Fallon, T. Kohs, A. Ngo, J. Shatzel, M. Hinds, O. McCarty, J. Aslan   +12 more
semanticscholar   +1 more source

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice

Haematologica, 2020
Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2.
Nathan Eaton, Caleb Drew, Jon Wieser, Adam D. Munday, Hervé Falet   +4 more
doaj   +1 more source

Expression and function of the collagen receptor GPVI during megakaryocyte maturation. [PDF]

, 2001
peer reviewedIn this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord blood derived CD34(+) cells.
Debili, N., Jandrot-Perrus, M., Kingbury, G., Lagrue-Lak-Hal, A. H., Le Couedic, J. P., Lecut, Christelle, Vainchenker, W., Villeval, J. L.   +7 more
core   +1 more source

Storage temperature determines platelet GPVI levels and function in mice and humans.

Blood Advances, 2021
Platelets are currently stored at room temperature before transfusion to maximize circulation time. This approach has numerous downsides, including limited storage duration, bacterial growth risk, and increased costs.
Jeffrey Miles, S. Bailey, Ava M. Obenaus, Molly Y. Mollica, Chomkan Usaneerungrueng, D. Byrne, Lydia Y Fang, Jake R Flynn, J. Corson, Barbara Osborne, Katie L. Houck, Yi Wang, Yu-Jia Shen, Xiaoyun Fu, Jing-fei Dong, N. Sniadecki, M. Stolla   +16 more
semanticscholar   +1 more source

GPVI and integrin αIIbβ3 signaling in platelets [PDF]

Journal of Thrombosis and Haemostasis, 2005
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alphaIIb beta3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to
Steve P. Watson, Andrew C. Pearce, Jocelyn M. Auger, Owen J. T. McCarty   +3 more
openaire   +3 more sources

Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets

Platelets, 2023
Alternate splicing is among the regulatory mechanisms imparting functional diversity in proteins. Studying protein isoforms generated through alternative splicing is therefore critical for understanding protein functions in many biological systems ...
Pankaj Kumar Singh, Carol A. Dangelmaier, Hymavathi Reddy Vari, Alexander Y. Tsygankov, Satya P. Kunapuli   +4 more
doaj   +1 more source

Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood [PDF]

, 2018
The platelet collagen receptor glycoprotein VI (GPVI) has been suggested to function as a dimer, with increased affinity for collagen. Dissociation constants (K(d)) obtained by measuring recombinant GPVI binding to collagenous substrates showed that GPVI
Berndt, Michael C., Bihan, Dominique, Gardiner, Elizabeth, Howse, Joanna-Marie, Jung, Stephanie M., Miura, Yoshiki, Moroi, Masaaki, Nakagaki, Tomohiro, Pugh, Nicholas, Soejima, Kenji, Watson, Steve P.   +10 more
core   +1 more source