Results 11 to 20 of about 5,253 (50)

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway

Molecular Medicine, 2023
Background Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal necrosis, distant organ involvement, or systemic reactions ...
Xingjie Wang, Tianli Shen, Jie Lian, Kai Deng, Chao Qu, Enmeng Li, Gan Li, Yiwei Ren, Zijun Wang, Zhengdong Jiang, Xuejun Sun, Xuqi Li   +11 more
semanticscholar   +1 more source

A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4

Theranostics
Background: Ferroptosis, a recently unveiled iron-dependent form of cellular demise, has emerged as a pivotal process contributing to the pathology of Alzheimer's Disease (AD).
Yuan-Yuan Yong, Lu Yan, Jing Wei, Chi Feng, Lu Yu, Jianming Wu, Minsong Guo, Dongsheng Fan, Chong-Lin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu   +11 more
semanticscholar   +1 more source

Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma

Human and Experimental Toxicology, 2023
Ferroptosis is potential to relieve drug resistance in hepatocellular carcinoma (HCC). Glutathione peroxidase 4 (GPX4) is a critical modulator of ferroptosis. This study discussed the mechanism of GPX4-inhibited ferroptosis in sorafenib resistance in HCC.
Xiaoming Li, Yunhui Li, Pei-long Lian, Qigang Lv, Fangfeng Liu   +4 more
semanticscholar   +1 more source

Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson’s Disease

Neurochemical Research
Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons, with ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential, this study aims to explore its capacity to mitigate ferroptosis in PD ...
Jun Shen, Shasha Chen, Xin Li, Lele Wu, Xue Mao, Jingjie Jiang, Dabu Zhu   +6 more
semanticscholar   +1 more source

α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway

Cellular & Molecular Biology Letters
Osteoarthritis (OA) is the most common degenerative joint disorder that causes disability in aged individuals, caused by functional and structural alterations of the knee joint.
Rong-Rong He, Yuchi Wei, Zeyu Peng, Jie Yang, Zhenwei Zhou, Ailin Li, Yongji Wu, Mingyue Wang, Xiangyan Li, Daqing Zhao, Zhonghua Liu, Haisi Dong, Xiangyang Leng   +12 more
semanticscholar   +1 more source

Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4

Nutrients, 2023
The mode and mechanism of diabetic periodontitis-induced alveolar-osteocyte death are still unclear. This study aimed to investigate the occurrence of ferroptosis in alveolar osteocytes during diabetic periodontitis and the therapeutic potential of ...
Yue Li, Zhiyi Huang, Shu-Shan Pan, Y. Feng, Haokun He, Shuguang Cheng, Lijing Wang, Liping Wang, J. Pathak   +8 more
semanticscholar   +1 more source

Targeting the MCP‐GPX4/HMGB1 Axis for Effectively Triggering Immunogenic Ferroptosis in Pancreatic Ductal Adenocarcinoma

Advancement of science
Induction of ferroptosis can inhibit cancer cells in vitro, however, the role of ferroptosis in treatment in vivo is controversial. The immunosuppressive cells activated by the ferroptotic tumor cells can promote the growth of residual tumor cells ...
Ge Li, Chengyu Liao, Jiang-zhi Chen, Zuwei Wang, Shuncang Zhu, Jianlin Lai, Qiaowei Li, Yinhao Chen, Dihan Wu, Jianbo Li, Yi Huang, Yi-Feng Tian, Yanling Chen, Shi Chen   +13 more
semanticscholar   +1 more source

A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease

Chemical Science, 2023
Ferroptosis, an iron-dependent cell death, plays a crucial role in the pathology of Alzheimer's disease (AD). Several characteristics of AD, including excessive iron accumulation, elevated lipid peroxide and reactive oxygen species (ROS) levels, and ...
Prayasee Baruah, H. Moorthy, Madhu Ramesh, Dikshaa Padhi, T. Govindaraju   +4 more
semanticscholar   +1 more source

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Journal of experimental & clinical cancer research : CR
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to ...
Ya-Tiao Qiao, Meng Su, Huifang Zhao, Huanle Liu, Chenxi Wang, Xintong Dai, Lingling Liu, Guangju Liu, Huanran Sun, Mingming Sun, Jiyan Wang, Zhen Li, Jun Fan, Quan Zhang, Chunshen Li, Fangmin Situ, Jun Xue, Zhenghu Jia, Chunze Zhang, Shuai Zhang, Changliang Shan   +20 more
semanticscholar   +1 more source

Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer

International Journal on Biological Sciences, 2023
Anomanolide C (AC), a natural withanolide isolated from Tubocapsicum anomalum, has been reported to have exhibits remarkable anti-tumour activities in several types of human cancers, particularly triple-negative breast cancer (TNBC).
Yanmei Chen, Wei Xu, Yang Liu, Jiahui Zhang, Yuan Yang, Zhi-wen Wang, De-juan Sun, Hua Li, Bo Liu, Li-Xia Chen   +9 more
semanticscholar   +1 more source