Results 11 to 20 of about 29,098 (325)
DHODH tangoing with GPX4 on the ferroptotic stage [PDF]
Signal Transduction and Targeted Therapy, 2021 Fudi Wang, Junxia Min
openalex +5 more sources
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]
Nature, 2019 Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo +43 more
core +6 more sources
Advanced ScienceAbstractThe standard regimen of gemcitabine combined with cisplatin offers limited clinical benefits in the treatment of advanced intrahepatic cholangiocarcinoma (ICC) due to intrinsic or acquired resistance. Currently, effective biomarkers to predict and improve chemotherapy resistance in ICC are lacking.
Zhi‐Wen Chen +13 more
openaire +3 more sources
Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]
, 2011 The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core +3 more sources
Development of Therapies for Rare Genetic Disorders of GPX4: Roadmap and Opportunities [PDF]
Orphanet Journal of Rare Diseases, 2021 Background: Extremely rare progressive diseases like Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD) can be neonatally lethal and therefore go undiagnosed or are difficult to treat. Recent sequencing efforts have linked this disease to mutations in GPX4, with consequences in the resulting enzyme, glutathione peroxidase 4.
Dorian M. Cheff +11 more
+12 more sources
GPX4 in cell death, autophagy, and disease [PDF]
Autophagy, 2023 Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products. There are three GPX4 isoforms: cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), with distinct ...
Yangchun Xie +3 more
openalex +3 more sources
Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently [PDF]
Journal of the American Chemical Society, 2019 GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. While most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein’s catalytic selenocysteine residue, the discovery and mechanistic elucidation of structurally diverse GPX4-inhibiting molecules has ...
John K. Eaton +4 more
openalex +4 more sources
A masked zinger to block GPX4 [PDF]
Nature Chemical Biology, 2020 Ferroptosis induced by GPX4 inhibition offers promise for killing drug-resistant cancer cells, yet current GPX4 inhibitors lack selectivity. The discovery of masked nitrile oxide electrophiles as selective prodrug inhibitors of GPX4 points to an attractive path for chemically inducing ferroptosis.
Stefan G. Kathman, Benjamin F. Cravatt
openaire +2 more sources
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
Autophagy, 2023 Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid hydroperoxides, the regulation of GPX4 remains poorly understood.
Qian‐Li Xue +9 more
openalex +3 more sources
Gut Microbes, 2021 Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut microbiota and metabolites in intestinal I/R and the role of gut microbiota metabolites on ...
Fan Deng +10 more
doaj +1 more source