Results 191 to 200 of about 29,098 (325)

Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway

, 2023
Shihua Deng, Jin Li, Li Li, Sheng Lin, Yueyan Yang, Teng Liu, Ting Zhang, Guangsu Xie, Dongming Wu, Ying Xu   +9 more
openalex   +2 more sources

High‑throughput screening identification of a small‑molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis

, 2023
Qi Huang, Jing Li, Mengqing Ma, Minling Lv, Rui Hu, Jialing Sun, Xin Zhong, Xinfeng Sun, Wenxing Feng, Wenfeng Ma, Wei Zhang, Bolin Zhan, Zhiyi Han, Xiaozhou Zhou   +13 more
openalex   +2 more sources

CircRHOT1 restricts gastric cancer cell ferroptosis by epigenetically regulating GPX4 [PDF]

, 2023
Huan Wang, Daniel Breadner, Ke Deng, Jing Niu   +3 more
openalex   +1 more source

GDF10 Regulates Iron‐Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang, Tianying Huang, Dan Xie, Hailin Xiong   +3 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

GPX4 activator enhances neuroprotection and functional recovery in spinal cord injury

Journal of Orthopaedic Translation
Background: Spinal cord injury (SCI) exerts severe physical, social, and economic effects on individuals and the healthcare system. While much progress has been made in understanding the pathophysiology of SCI, the regulation of the ferroptosis master ...
Xinjie Liu, Yilin Pang, Baoyou Fan, Jiawei Zhang, Shen Liu, Xiaobing Deng, Yun Li, Ying Liu, Xu Zhang, Chenxi Zhao, Xiaoyu Wang, Xudong Wu, Luhua Lai, Shiqing Feng, Wenpeng Liu, Guangzhi Ning, Xue Yao   +16 more
doaj  

Cholesterol Hydroperoxide Co-trafficking in Testosterone-generating Leydig Cells: GPx4 Inhibition of Cytotoxic and Anti-steroidogenic Effects [PDF]

, 2023
Paweł Pabisz, Jerzy Bazak, Michał J. Sabat, Albert W. Girotti, Witold Korytowski   +4 more
openalex   +1 more source

The effect of sodium nitroprusside in scaffolds for synergetic gas‐photothermal therapy of osteosarcoma

BMEMat, EarlyView.
The PCLA‐SNP scaffolds can produce photothermal agents in situ under ultraviolet radiation. Then, the scaffold can release nitric oxide gas spontaneously and generate hyperthermia under near‐infrared laser to enhance ablation of bone tumors. Furthermore, the calcium and iron ions released from PCLA‐SNP scaffolds can accelerate bone regeneration ...
Shaojie Dong, Yuwei Zhang, Yukun Mei, Changjie Sun, Xingge Yu, Mazaher Gholipourmalekabadi, Kaili Lin, Lin Niu, Li Zhao, Changyong Yuan   +9 more
wiley   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability [PDF]

, 2023
Jun Wang, Long Liao, Bo Yang, Beiping Miao, Botai Li, Xuhui Ma, Annika Fitz, Shanshan Wu, Jia He, Qianqian Zhang, Shuyi Ji, Guang‐Zhi Jin, Jianming Zhang, René Bernards, Wenxin Qin, Chong Sun, Cun Wang   +16 more
openalex   +1 more source