Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population [PDF]
, 2012 BACKGROUND: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes ...
A Comandini +76 more
core +17 more sources
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj +1 more source
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Endocrine Connections, 2023 Background: Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS.
Hong Tang +7 more
doaj +1 more source
Regulation of Ferroptotic Cancer Cell Death by GPX4 [PDF]
Cell, 2014 Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds ...
Paul A. Clemons +15 more
openaire +3 more sources
Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]
, 2015 The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M +12 more
core +1 more source
Characterization of a patient-derived variant of GPX4 for precision therapy
Nature Chemical Biology, 2021 Glutathione peroxidase 4 (GPX4), as the only enzyme in mammals capable of reducing esterified phospholipid hydroperoxides within a cellular context, protects cells from ferroptosis. We identified a homozygous point mutation in the GPX4 gene, resulting in an R152H coding mutation, in three patients with Sedaghatian-type spondylometaphyseal dysplasia ...
Hengrui Liu +10 more
openaire +3 more sources
The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids [PDF]
, 2013 © 2013 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH Verlag GmbH & Co.
Akbaraly +31 more
core +2 more sources
Selenium and GPX4, a vital symbiosis
Free Radical Biology and Medicine, 2018 Selenium has transitioned from an environmental poison and carcinogen to an essential micronutrient associated with a broad array of health promoting effects. These beneficial effects are now accepted to be linked to its incorporation into selenoproteins, a family of rare proteins utilizing a specialized translation machinery to integrate selenium in ...
Friedmann Angeli, J.P.F., Conrad, M.
openaire +5 more sources
MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. [PDF]
, 2018 We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal.
Abe, Hiroshi +10 more
core +3 more sources
HOIP modulates the stability of GPx4 by linear ubiquitination
Proceedings of the National Academy of Sciences, 2022 LUBAC-mediated linear ubiquitination plays a pivotal role in regulation of cell death and inflammatory pathways. Genetic deficiency in LUBAC components leads to severe immune dysfunction or embryonic lethality. LUBAC has been extensively studied for its role in mediating TNF signaling. However, Tnfr1 knockout is not
Kangyun Dong +8 more
openaire +2 more sources