Results 21 to 30 of about 5,253 (50)

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc

Cellular and molecular life sciences : CMLS
Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative disorders and imposes places heavy medical and economic burdens on individuals and society.
Chunwang Jia, Ziqian Xiang, Pengfei Zhang, Long Liu, Xuetao Zhu, Ruixuan Yu, Zhicheng Liu, Shaoyi Wang, Kaiwen Liu, Zihao Wang, Krasimir Vasilev, Shuanhu Zhou, Ziwen Geng, Xinyu Liu, Yunpeng Zhao, Yuan Gao, Lei Cheng, Yuhua Li   +17 more
semanticscholar   +1 more source

LRRK2 regulates ferroptosis through the system Xc‐GSH–GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease

Journal of Cellular Physiology
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in the midbrain are its primary pathological manifestations.
Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiang-Dang Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui Lu   +10 more
semanticscholar   +1 more source

Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

Cell, 2023
Deguang Liang, Yan Feng, Fereshteh Zandkarimi, Hua Wang, Zeda Zhang, Jinnie Kim, Yanyan Cai, Wei Gu, B. Stockwell, Xuejun Jiang   +9 more
semanticscholar   +1 more source

Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia

Experimental Hematology & Oncology
Background Ferroptosis is a new form of nonapoptotic and iron-dependent type of cell death. Glutathione peroxidase-4 (GPX4) plays an essential role in anti-ferroptosis by reducing lipid peroxidation.
Shuya Feng, Yigang Yuan, Zihan Lin, Min Li, Daijiao Ye, Liuzhi Shi, Danyang Li, Min Zhao, Chen Meng, Xiaofei He, Shanshan Wu, Fang Xiong, Siyu Ye, Junjun Yang, Haifeng Zhuang, Lili Hong, Shenmeng Gao   +16 more
semanticscholar   +1 more source

Berberine-mediated Ferroptosis through System Xc-/GSH/GPX4 Axis Inhibits Metastasis of Nasopharyngeal Carcinoma

Journal of Cancer
Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Southeast China, and its metastasis remains an unresolved clinical problem.
Yao Wu, Qunying Jia, Qi Tang, Hongyu Deng, Yingchun He, Faqin Tang   +5 more
semanticscholar   +1 more source

Circ0060467 sponges miR-6805 to promote hepatocellular carcinoma progression through regulating AIFM2 and GPX4 expression

Aging
Background: Circular RNAs (circRNAs) represent a subset of non-coding RNAs implicated in the regulation of diverse biological processes, including tumorigenesis.
Ye-Ru Tan, Bao-Hong Jiang, Wenjie Feng, Zhi-Long He, Yi-Ling Jiang, Yi Xun, Xiao-Ping Wu, Yuehua Li, Hongbo Zhu   +8 more
semanticscholar   +1 more source

Regulation of Ferroptotic Cancer Cell Death by GPX4

Cell, 2014
W. Yang, Rohitha Sriramaratnam, Matthew E. Welsch, K. Shimada, R. Skouta, V. Viswanathan, J. Cheah, P. Clemons, Alykhan F. Shamji, C. Clish, L. Brown, A. Girotti, V. Cornish, S. Schreiber, B. Stockwell   +14 more
semanticscholar   +1 more source

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Cell Death and Disease
Pancreatic cancer is one of the most malignant tumor types and is characterized by high metastasis ability and a low survival rate. As a chromatin-binding protein, HMGA2 is widely overexpressed and considered an oncogene with various undefined regulatory
Ziyang Luo, Qingfang Zheng, Shazhou Ye, Yanguo Li, Jiayi Chen, Chengjiang Fan, Jianing Chen, Yuxin Lei, Qi Liao, Yang Xi   +9 more
semanticscholar   +1 more source

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

Redox Biology, 2023
Dorian M. Cheff, Chuying Huang, Karoline C. Scholzen, R. Gencheva, Michael H. Ronzetti, Q. Cheng, M. Hall, Elias S. J. Arnér   +7 more
semanticscholar   +1 more source

Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression

EBioMedicine, 2022
Yuanxin Miao, Yiwei Chen, Feng Xue, Kexin Liu, Bin Zhu, Junjie Gao, J. Yin, Changqing Zhang, Guangyi Li   +8 more
semanticscholar   +1 more source