Results 291 to 300 of about 40,571 (376)

A novel antitumor mechanism of triptonide in colorectal cancer: inducing ferroptosis via the SLC7A11/GPX4 axis

Weijie Wang, Zhao Xiaofen, Jie Zhou, Hai Li   +3 more
openalex   +1 more source

Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling.

International Immunopharmacology
Juan Xiao, Chenggen Luo, Anmao Li, Fanglan Cai, Yu Wang, Xiaoli Pan, Liu Xu, Zihong Wang, Zhouxiong Xing, Limei Yu, Yong Chen, Mei Tian   +11 more
semanticscholar   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration. [PDF]

Redox Rep
Zhou LP, Wang JQ, Kang L, Hou YX, Yan X, Zhao CH, Jia CY, Zhang HQ, Zhang RJ, Shen CL.   +9 more
europepmc   +1 more source

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis

Yao Shi, Changju Ma, Xiaojuan Tang, Haojie Su, Yue Lu, Jianan Wei, Li Li, Tianhua Huang, Xicheng Wang, Xintian Qin, Ying Ding, Ling Han, Jingjing Wu   +12 more
openalex   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, EarlyView.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Exploiting Oxidative Stress as Achilles' Heel: From Redox Homeostasis to Ferroptosis in Prostate Cancer. [PDF]

Antioxidants (Basel)
Yu S, Baek J, Choi T, Kim MS.
europepmc   +1 more source

Right-Sided Stellate Ganglion Block Ameliorates Insomnia-Induced Neuronal Damage and Cognitive Impairment by Suppressing Ferroptosis via NRF2/GPX4 Pathway [PDF]

Meiyue Liu, Xi Ouyang, Yang Shao, Qingming Zhang   +3 more
openalex   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Targeting ferroptosis to overcome drug resistance in lung cancer. [PDF]

Transl Lung Cancer Res
Sheng P, Jin J, Liu H, Sun C, Chen Y, Chen X, Ma D, Shen J.   +7 more
europepmc   +1 more source