Results 91 to 100 of about 1,018,561 (360)

The History, Current Status, Benefits, and Challenges of 3D Printed Organs [PDF]

arXiv, 2022
There is an increase in demand for organs as transplantation is becoming a common practice to elongate human life. To reach this demand, three-dimensional bioprinting is developing from prior knowledge of scaffolds, growth factors, etc. This review paper aims to determine the current status and future possibilities of three-dimensional bioprinting of ...
arxiv  

Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss.

Journal of the American Society of Nephrology, 2015
Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment of individual risk at diagnosis is impeded by the lack of a reliable prognosis assay.
A. Sicard, S. Ducreux, M. Rabeyrin, L. Couzi, B. McGregor, L. Badet, J. Scoazec, T. Bachelet, S. Lepreux, J. Visentin, P. Merville, V. Frémeaux-Bacchi, E. Morelon, J. Taupin, V. Dubois, O. Thaunat   +15 more
semanticscholar   +1 more source

Corneal Allograft Rejection: Immunopathogenesis to Therapeutics [PDF]

, 2014
Corneal transplantation is among the most successful solid organ transplants. However, despite low rejection rates of grafts in the ‘low-risk’ setting, rejection can be as high as 70% when grafted into ‘high-risk’ recipient beds. Under normal homeostatic
Hamrah, Pedram, Qazi, Yureeda
core   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing.

PLoS ONE
BackgroundThe demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and reduced graft ...
Xihao Shen, Jiyue Wu, Feilong Zhang, Qing Bi, Zejia Sun, Wei Wang   +5 more
doaj   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]

, 2017
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L, Reed, Elaine F, Thomas, Kimberly A, Valenzuela, Nicole M   +3 more
core   +4 more sources

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Resident memory T cells form during persistent antigen exposure leading to allograft rejection

Science immunology, 2021
Recipient effector T cells differentiate into functional tissue-resident memory T cells, causing graft rejection after kidney transplantation. Memories of rejection Long-term graft survival after organ transplantation can be hindered by immune-mediated ...
Khodor I. Abou-Daya, R. Tieu, Daqiang Zhao, R. Rammal, F. Sacirbegovic, Amanda L. Williams, W. Shlomchik, M. Oberbarnscheidt, Fadi G Lakkis   +8 more
semanticscholar   +1 more source

Management and prevention of corneal graft rejection

Indian Journal of Ophthalmology, 2023
The management of an episode of corneal graft rejection (CGR) is primarily by corticosteroids. Immunomodulators are useful for long-term immunosuppression and in dealing with cases of high-risk (HR) corneal grafts. The classical signs of CGR following penetrating keratoplasty (PKP) include rejection line, anterior chamber (AC) reaction, and graft edema.
Sohini Mandal, Prafulla K Maharana, Luci Kaweri, Mohamed I Asif, Ritu Nagpal, Namrata Sharma   +5 more
openaire   +3 more sources