Results 51 to 60 of about 86,493 (358)

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: randomized phase II results

Haematologica, 2018
Aprior phase I/II trial of bortezomib/tacrolimus/methotrexate prophylaxis after human leukocyte antigen (HLA)-mismatched reduced intensity conditioning allogeneic hematopoietic stem cell transplantation documented low acute graft-versus-host disease ...
John Koreth, Haesook T. Kim, Paulina B. Lange, Samuel J. Poryanda, Carol G. Reynolds, Sharmila Chamling Rai, Philippe Armand, Corey S. Cutler, Vincent T. Ho, Brett Glotzbecker, Rushdia Yusuf, Sarah Nikiforow, Yi-Bin Chen, Bimalangshu Dey, Malgorzata McMasters, Jerome Ritz, Bruce R. Blazar, Robert J. Soiffer, Joseph H. Antin, Edwin P. Alyea   +19 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Ruxolitinib in steroid refractory graft-vs.-host disease: a case report

Journal of Hematology & Oncology, 2016
Background Allogeneic hematopoietic stem cell transplantation (HSCT) is potentially curative in a variety of hematological malignancies. Graft-vs.-host disease (GvHD) remains a life-threatening complication.
Enrico Maffini, Luisa Giaccone, Moreno Festuccia, Lucia Brunello, Ilaria Buondonno, Dario Ferrero, Mario Boccadoro, Chiara Dellacasa, Alessandro Busca, Domenico Novero, Benedetto Bruno   +10 more
doaj   +1 more source

Biomarkers in ocular chronic graft versus host disease: tear cytokine- and chemokine-based predictive model. [PDF]

, 2016
Producción CientíficaPurpose: To develop a tear molecule level-based predictive model based on a panel of tear cytokines and their correlation with clinical features in ocular chronic graft versus host disease (cGVHD).
Caballero, Dolores, Calonge Cano, Margarita, Cocho, Lidia, Enríquez de Salamanca y Aladro, Amalia, Fernández Martínez, Itziar, García Vázquez, Carmen, González García, María Jesús, López Corral, Lucía, Martínez, Verónica, Stern, Michael E., Vázquez, Lourdes   +10 more
core   +2 more sources

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance

Frontiers in Immunology, 2019
Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Hongshuang Yu, Yuanyuan Tian, Ying Wang, Shin Mineishi, Yi Zhang, Yi Zhang   +5 more
doaj   +1 more source

Intestinal transplantation in composite visceral grafts or alone [PDF]

, 1992
Under FK 506-based immunosuppression, the entire cadaver small bowel except for a few proximal and distal centimeters was translated to 17 randomly matched patients, of whom two had antigraft cytotoxic antibodies (positive cross-match).
Abu-Elmagd, K, Busuttil, RW, Casavilla, A, Demetris, AJ, Fung, JJ, Nakamura, K, Nour, BM, Rapaport, FT, Reyes, J, Selby, R, Shaw, BW, Starzl, TE, Thompson, JC, Todo, S, Tzakis, AG, Van Thiel, DH, Vasconez, LO, Wright, H   +17 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity and cancer

Frontiers in Immunology, 2013
A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance.
Erin E Hillhouse, Jean-Sébastien eDelisle, Sylvie eLesage   +2 more
doaj   +1 more source

Pathogenetic role of tissue factor in graft-versus-host disease [PDF]

, 2008
Graft-versus-host disease (GVHD) is a serious complication after allogeneic stem cell transplantation, the mechanism of it is still not elucidated.
Li Quan, Li Weiming, Zhang Jian, Zou Ping   +3 more
core   +1 more source