Results 91 to 100 of about 102,482 (316)

Yukawa unification with four Higgs doublets in supersymmetric GUT

Physics Letters B, 2019
We discuss the Yukawa coupling unification, which can emerge in the grand unified theory, in the context of scenarios with more than one pair of Higgs doublet since the current LHC constraint has become a problem for the Yukawa unification scenarios with
Bhaskar Dutta, Yukihiro Mimura
doaj   +1 more source

See-saw and grand unification

, 2005
I review the profound connection between the see-saw mechanism for neutrino masses and grand unification. This connection points naturally towards SO(10) grand unified theory.
Senjanovic, Goran
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A realistic theory of E6 unification through novel intermediate symmetries

Journal of High Energy Physics
We propose a non-supersymmetric E6 GUT with the scalar sector consisting of 650 ⨁ 351′ ⨁ 27. Making use of the first representation for the initial symmetry breaking to an intermediate stage, and the latter two representations for second-stage breaking ...
K. S. Babu, Borut Bajc, Vasja Susič
doaj   +1 more source

Nucleon decay via dimension 6 operators in anomalous U(1)_A SUSY GUT

, 2013
Nucleon lifetimes for various decay modes via dimension 6 operators are calculated in the anomalous $U(1)_A$ GUT scenario, in which the unification scale $\Lambda_u$ becomes smaller than the usual supersymmetric (SUSY) unification scale $\Lambda_G=2 ...
Maekawa, Nobuhiro, Muramatsu, Yu
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Small instantons and the post-inflationary QCD axion in a special product GUT

Journal of High Energy Physics
We present a new framework of grand unification that is equipped with an axion solution to the strong CP problem without a domain wall problem when the Peccei-Quinn (PQ) symmetry is spontaneously broken after inflation.
Shihwen Hor, Yuichiro Nakai, Motoo Suzuki, Junxuan Xu   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source