Results 51 to 60 of about 272,903 (354)
The unusual microtubule polarity in teleost retinal pigment epithelial cells. [PDF]
, 1988 In cells of the teleost retinal pigment epithelium (RPE), melanin granules disperse into the RPE cells long apical projections in response to light onset, and aggregate toward the base of the RPE cell in response to dark onset.
BURNSIDE, Beth, Troutt, L
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis
Cell Reports, 2017 The prohormone VGF is expressed in neuroendocrine and endocrine tissues and regulates nutrient and energy status both centrally and peripherally. We and others have shown that VGF-derived peptides have direct action on the islet β cell as secretagogues ...
Samuel B. Stephens +6 more
doaj +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. [PDF]
, 1985 We have previously characterized a monoclonal antibody, S12, that binds only to activated platelets (McEver, R.P., and M.N. Martin, 1984, J. Biol. Chem., 259:9799-9804). It identifies a platelet membrane protein of Mr 140,000, which we have designated as
Bainton, DF +4 more
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Dynamics of small-scale convective motions
, 2016 Previous studies have discovered a population of small granules with diameters less than 800 km showing differing physical properties. High resolution simulations and observations of the solar granulation, in combination with automated segmentation and ...
Hanslmeier, Arnold +3 more
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
eLife, 2018 Alternative polyadenylation (APA) regulates mRNA translation, stability, and protein localization. However, it is unclear to what extent APA regulates these processes uniquely in specific cell types.
Saša Jereb +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Isoperimetric Partitioning: A New Algorithm for Graph Partitioning [PDF]
, 2003 Temporal structure is skilled, fluent action exists at several nested levels. At the largest scale considered here, short sequences of actions that are planned collectively in prefronatal cortex appear to be queued for performance by a cyclic competitive
Grady, Leo, Schwartz, Eric
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