Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease
Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler+18 more
wiley +1 more source
Separation of functionally distinct human granulocyte-macrophage colony- stimulating factors [PDF]
Nicos A. Nicola+3 more
openalex +1 more source
Objective Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet+18 more
wiley +1 more source
Implantation of fibroblasts transfected with human granulocyte colony- stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy [PDF]
Kenzaburo Tani+9 more
openalex +1 more source
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han+11 more
wiley +1 more source
Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin E2. [PDF]
Stefan Heidenreich+4 more
openalex +1 more source
Combating cancer immunotherapy resistance: a nano‐medicine perspective
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong+10 more
wiley +1 more source
Recombinant granulocyte colony stimulating factor biosimilars. Quality assessment
The article describes general principles of evidence-based quality assessment research of a recombinant granulocyte colony stimulating factor preparation (G-CSF) under development as well as a confirmation of its similarity to reference preparation ...
Zh. I. Avdeeva+9 more
doaj
Modeling the Hematopoietic Landscape
Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell options and can then “merely” differentiate.
Geoffrey Brown, Rhodri Ceredig
doaj +1 more source
Human Recombinant Granulocyte-Macrophage Colony-Stimulating Factor: A Multilineage Hematopoietin [PDF]
Colin A. Sieff+6 more
openalex +1 more source