Results 51 to 60 of about 79,933 (320)

Bridging Time Scales in Cellular Decision Making with a Stochastic Bistable Switch [PDF]

, 2010
Cellular transformations which involve a significant phenotypical change of the cell's state use bistable biochemical switches as underlying decision systems.
A Gougeon, A Raj, B Munsky, BB Kaufmann, C Song, CV Rao, DH Castrillon, DT Gillespie, DT Gillespie, E Nilsson, EE Nilsson, FJ Isaacs, Frank Allgöwer, HL Smith, J Nuño, J Ross, J Yeh, JA Parrott, JA Parrott, JA Visser, JE Ferrell, JE Ferrell, JE Fortune, Jingbo Wu, JL Cherry, JL Hargrove, JP de Bruin, JT Mettetal, L Warren, M Kaufman, MJ Faddy, MJ Faddy, MK Skinner, ML Martins, NG van Kampen, P Lancaster, PD Silva-Buttkus, R Braw-Tal, S Krishnamurthy, S Ramsey, Steffen Waldherr, T Eissing, T Eissing, T Tian, V Chickarmane   +44 more
core   +4 more sources

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Granulosa Cell Tumors

Journal of Institute of Medicine Nepal, 2008
N ...
Alan L. Johnson, Dori C. Woods
  +4 more sources

The adipokines progranulin and omentin – novel regulators of basic ovarian cell functions

Reproductive Biology and Endocrinology
The present study aimed to examine the effects of progranulin and omentin on basic ovarian cell functions. For this purpose, we investigated the effects of the addition of progranulin and omentin (0, 0.1, 1, or 10 ng/ml) on the viability, proliferation ...
Alexander V Sirotkin, Zuzana Fabová, Barbora Loncová, Maria Bauerová, Abdel Halim Harrath   +4 more
doaj   +1 more source

Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells

Reproductive Biology and Endocrinology, 2010
Background Homeobox (HOX) genes encode transcription factors, which regulate cell proliferation, differentiation, adhesion, and migration. The deregulation of HOX genes is frequently associated with human reproductive system disorders. However, knowledge
Yanase Toshihiko, Nishi Yoshihiro, Cheng Jung-Chien, Huang Qing, Zhang Yu, Huang He-Feng, Leung Peter CK   +6 more
doaj   +1 more source

Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice. [PDF]

PLoS ONE, 2018
It has been known that EGF-like factor secreted from LH-stimulated granuloma cells acts on granulosa cells and cumulus cells to induce ovulation process.
Hiroya Kitasaka, Tomoko Kawai, S A Masudul Hoque, Takashi Umehara, Youko Fujita, Masayuki Shimada   +5 more
doaj   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Granulosa cell tumor of testis: Clinicopathological correlation of a rare tumor

Indian Journal of Pathology and Microbiology, 2014
Background: Granulosa cell tumor of testis is a rare tumor accounting for less than 4% of adult testicular tumors though they account for nearly 30% of childhood testicular tumors.
Swapnil Ulhas Rane, Santosh Menon, Sangeeta Desai, Ganesh Bakshi, Amit Joshi   +4 more
doaj   +1 more source

Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis

Journal of Biomedical Science, 2021
Objective Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand the role of nuclear-enriched abundant transcript 1 (NEAT1) and miR-381 ...
Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun, Qi Yu   +6 more
doaj   +1 more source

Biosynthesis and expression of zona pellucida glycoproteins in mammals [PDF]

, 2001
The zona pellucida (ZP) is an extracellular matrix surrounding the oocyte and the early embryo that exerts several important functions during fertilization and early embryonic development.
Kölle, S., Sinowatz, Fred, Töpfer-Petersen, E.   +2 more
core   +1 more source