Results 61 to 70 of about 3,866 (172)
Granulysin-Mediated Tumor Rejection in Transgenic Mice [PDF]
The Journal of Immunology, 2007 Abstract Granulysin (GNLY) is a cytolytic molecule expressed by human CTL and NK cells with activity against a variety of tumors and microbes, including Mycobacterium tuberculosis. Although the molecular mechanism of GNLY-induced apoptosis of Jurkat T cells is well defined in vitro, no direct evidence for its in vivo effects has been ...
Lisa P, Huang +3 more
openaire +2 more sources
Spatial omics for profiling the dynamic tumor microenvironment
Clinical &Translational Immunology, Volume 15, Issue 4, 2026.Spatially resolved transcriptomics and proteomics map RNA/protein in intact tumor tissues, revealing crucial cancer–immune interactions across the different stages of tumor evolution. Integrating AI promises translational impact, but gaps in cross‐platform integration, standards, compute, validation and interpretability remain.
Hao Nguyen +3 more
wiley +1 more source
Activated cytotoxic T cells within zoonotic cutaneous leishmaniasis lesions
Immunity, Inflammation and Disease, 2019 Introduction Zoonotic cutaneous leishmaniasis (ZCL), due to infection by Leishmania (L). major, is characterized by polymorphic clinical manifestations which could be attributed to the host's immune response. In this study we investigated the involvement
Thouraya Boussoffara +6 more
doaj +1 more source
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): an update
South African Family Practice, 2016 Stevens-Johnson syndrome (SJS) is a form of toxic epidermal necrolysis (TEN) a rare but life-threatening hypersensitivity reactions that affect the skin and mucous membranes.
O. Mogole +2 more
doaj +1 more source
Scientific Reports, 2021 Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions with high mortality rates. Its sequelae, such as blindness, persist even after recovery.
Rawiphan Panpruk +6 more
doaj +1 more source
Cytometry Part A, Volume 109, Issue 4, Page 241-256, April 2026.ABSTRACT Rapid advancements in mass and flow cytometry technologies have allowed researchers to generate and analyze high‐dimensional single cell datasets, often utilizing upwards of 40 protein markers. Such high‐parameter cytometry is increasingly used in longitudinal immunological studies, but technical variations across experimental batch runs can ...
Shruti Eswar +5 more
wiley +1 more source
پژوهش در دین و سلامت, 2016 For downloading the full-text of this article please click here. Background and Objectives: Plasma granulysin levels as a biomarker of the immune system are currently being considered. NK cells are a major source of plasma granulysin.
Kanan Gorjipour +2 more
doaj
iMeta, Volume 5, Issue 2, April 2026.The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang +13 more
wiley +1 more source
PLoS Biology, 2020 Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1).
Caroline Boulouis +15 more
doaj +1 more source
Advanced extracellular vesicle immunotherapy
FlexMat, Volume 3, Issue 1, Page 117-143, March 2026.A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang +6 more
wiley +1 more source