Results 51 to 60 of about 3,866 (172)

Progress of Immunotherapies in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng, Xu‐hui Kang, Shun‐yu Yao, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Dai‐yi Jiang, Quan Chen, Hong Jin   +10 more
wiley   +1 more source

The role of GNLY gene polymorphisms in psoriasis pathogenesis [PDF]

Anais Brasileiros de Dermatologia, 2019
BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with
Esra Ermis, Sevim Karakas Celik, Nilgun Solak, Gunes Cakmak Genc, Ahmet Dursun   +4 more
doaj   +1 more source

Intracellular Mediators of Granulysin-Induced Cell Death [PDF]

The Journal of Immunology, 2003
Abstract Granulysin, a molecule present in the granules of CTL and NK cells, is cytolytic against microbes and tumors. Granulysin induces apoptosis of mammalian cells by damaging mitochondria and causing the release of cytochrome c and apoptosis-inducing factor, resulting in DNA fragmentation. Here we show that Ca2+ and K+ channels as
Satoshi, Okada, Qing, Li, John C, Whitin, Carol, Clayberger, Alan M, Krensky   +4 more
openaire   +2 more sources

Severe Cutaneous Adverse Reactions Associated With Newer‐Generation Antiseizure Medications: A Real‐World Pharmacovigilance Study Based on FAERS and JADER

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A cross‐database analysis of FAERS and JADER confirmed lamotrigine and zonisamide as the dominant SJS/TEN/DRESS risk drivers across both systems. After polytherapy adjustment, eslicarbazepine (DRESS, ROR 10.41) and levetiracetam emerged as reproducible novel signals warranting clinical attention. SJS/TEN onset concentrated within 4 weeks, whereas DRESS
Longfei You, Dong Zhang, Zhihua Cheng, Yinbao Qi, Ruobing Qian   +4 more
wiley   +1 more source

The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Clinical and Applied Thrombosis/Hemostasis, 2021
Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are Severe Cutaneous Adverse Reactions (SCARS) characterized by fever and mucocutaneous lesions leading to necrosis and sloughing of the epidermis.
Michael Sadek MD, Omer Iqbal MD, Fakiha Siddiqui BDS, Sean Till MD, Melissa Mazariegos BS, Edward Campbell PhD, Kumaran Mudaliar MD, Jodi Speiser MD, Emily Bontekoe BS, Ahmed Kouta RPH, Ambar Farooqui MD, Bharathi Daravath MD, Dalia Qneibi MD, Ramy Sadek MD, Debra Hoppensteadt PhD, Jawed Fareed PhD, Charles Bouchard MD   +16 more
doaj   +1 more source

A case of Stevens–Johnson syndrome‐like eruption suggesting clinical importance of body temperature and serum levels of receptor‐interacting kinase 3

Journal of Cutaneous Immunology and Allergy, 2021
The present case is distinguished from Stevens–Johnson syndrome in that no elevation of serum receptor‐interacting kinase 3, low level of serum granulysin, and the rather good general status, including no fever‐up and rapid response to treatment.
Ryo Nishiyori, Mayuko Goto‐Umeki, Akito Hasegawa, Natsumi Hama, Haruto Nishida, Tsutomu Daa, Riichiro Abe, Yutaka Hatano   +7 more
doaj   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, Volume 11, Issue 10, 22 May 2026.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease

Nature Communications, 2021
Phenotypic markers that overlap between ILC1 and NK populations have impacted the robust and specific analysis of these immune cell populations. Employing scRNA sequencing here the authors identify CD127+ CD94+ innate lymphoid cells that express ...
L. Krabbendam, B. A. Heesters, C. M. A. Kradolfer, N. J. E. Haverkate, M. A. J. Becker, C. J. Buskens, W. A. Bemelman, J. H. Bernink, H. Spits   +8 more
doaj   +1 more source

Characterization of Bovine Homologues of Granulysin and NK-lysin [PDF]

The Journal of Immunology, 2004
Abstract Granulysin and NK-lysin are antimicrobial proteins found in the granules of human and swine cytotoxic lymphocytes. A murine counterpart to granulysin has not been identified to date, indicating the importance of additional models to fully characterize the role of granulysin-like molecules in the immune response to infectious ...
Janice J, Endsley, Jason L, Furrer, Mark A, Endsley, Mark A, McIntosh, Alexander C, Maue, W Ray, Waters, David R, Lee, D Mark, Estes   +7 more
openaire   +2 more sources

A multicentre analysis of efficacy, safety and molecular response correlates of fostamatinib in warm autoimmune haemolytic anaemia and Evans syndrome

British Journal of Haematology, Volume 208, Issue 5, Page 1878-1884, May 2026.
Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez, Lipei Shao, Debbie Jiang, Lawrence S. Bailey, Thejaswi Bikkani, Aaron Boothby, Donald C. Moore, Irina Murakhovskaya, Caroline I. Piatek, Mauricio Pineda‐Roman, Ping Jin, Jacqueline N. Poston, Moritz Stolla, David F. Stroncek, Krystalyn E. Hudson, James B. Bussel, Sandhya R. Panch   +16 more
wiley   +1 more source