Results 41 to 50 of about 3,866 (172)

Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease

Case Reports in Dermatology, 2013
Graft-versus-host disease (GVHD) is an important complication of bone marrow transplantation and is known to induce sweat gland abnormalities. We employed immunohistochemical staining for granulysin, dermcidin as well as IL-17 and Foxp3 in the lesional ...
Sadanori Furudate, Taku Fujimura, Yumi Kambayashi, Setsuya Aiba   +3 more
doaj   +1 more source

A lipopeptide facilitate induction of Mycobacterium leprae killing in host cells. [PDF]

PLoS Neglected Tropical Diseases, 2011
Little is known of the direct microbicidal activity of T cells in leprosy, so a lipopeptide consisting of the N-terminal 13 amino acids lipopeptide (LipoK) of a 33-kD lipoprotein of Mycobacterium leprae, was synthesized. LipoK activated M.
Yumi Maeda, Toshiki Tamura, Yasuo Fukutomi, Tetsu Mukai, Masanori Kai, Masahiko Makino   +5 more
doaj   +1 more source

An atomic-force basis for the bacteriolytic effects of granulysin [PDF]

Colloids and Surfaces B: Biointerfaces, 2012
While granulysin has been suggested to play an important role in adaptive immune responses against bacterial infections by killing pathogens, and molecular force for protein-protein interaction or protein-bacteria interaction may designate the specific functions of a protein, the molecular-force basis underlying the bacteriolytic effects of granulysin ...
Yueqin, Qiu, An-Bin, Hu, Huiyong, Wei, Hongying, Liao, Shaoyuan, Li, Crystal Y, Chen, Weihua, Zhong, Dan, Huang, Jiye, Cai, Lifang, Jiang, Gucheng, Zeng, Zheng W, Chen   +11 more
openaire   +2 more sources

15 kDa Granulysin versus GM-CSF for monocytes differentiation: analogies and differences at the transcriptome level

Journal of Translational Medicine, 2011
Background Granulysin is an antimicrobial and proinflammatory protein with several isoforms. While the 9 kDa isoform is a well described cytolytic molecule with pro-inflammatory activity, the functions of the 15 kDa isoform is less well understood ...
Krensky Alan M, Clayberger Carol, Marincola Francesco M, Wang Ena, Finn Michael W, Stroncek David F, Castiello Luciano, Sabatino Marianna   +7 more
doaj   +1 more source

Immunomodulatory effects of flavonoids: An experimental study on natural-killer-cell-mediated cytotoxicity against lung cancer and cytotoxic granule secretion profile

Proceedings of Singapore Healthcare, 2021
Background: A new approach involving immune-cell-mediated cancer therapy has been adopted extensively for the sake of lung cancer treatments by utilizing natural killer (NK) cells.
Aung Myo Oo, Liyana Hazwani Mohd Adnan, Nasir Mat Nor, Nordin Simbak, Nor Zidah Ahmad, Ohn Mar Lwin   +5 more
doaj   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, Volume 13, Issue 35, 24 June 2026.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth

Clinical and Developmental Immunology, 2011
Background. While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection. However,
Patricia L. Semple, Marcia Watkins, Virginia Davids, Alan M. Krensky, Willem A. Hanekom, Gilla Kaplan, Stanley Ress   +6 more
doaj   +1 more source

Significance of Granulysin in Cancer Immunology

Annals of Cancer Research and Therapy, 2008
Granulysin is a recently characterized cytotoxic granule expressed in cytotoxic T cells and NK cells. Although its cytotoxic effect against a number of tumor cell lines has been demonstrated in vitro, recent study with transgenic mice, and a number of clinical studies, have further established its significance in cancer immunology. Granulysin may offer
Okada, Satoshi, Morishita, Tetsuo
openaire   +2 more sources

Expression of granulysin in polymyositis and inclusion-body myositis [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2006
Granulysin, a recently defined cytolytic molecule, is expressed in cytotoxic T cells and natural killer cells in a similar way to perforin, which is reported to have a major role in the pathogenesis of polymyositis and inclusion-body myositis (IBM).To clarify the role of granulysin in polymyositis and IBM.The expression of granulysin and perforin was ...
K, Ikezoe, S, Ohshima, M, Osoegawa, M, Tanaka, K, Ogawa, K, Nagata, J-i, Kira   +6 more
openaire   +2 more sources

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source