Results 21 to 30 of about 3,866 (172)

Immune endotypes in tuberculosis: Keys to decoding disease complexity. [PDF]

J Intern Med
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Alipoor SD, Guthrie J, Forsman LD, Di Nardo AR, Brighenti S.   +4 more
europepmc   +2 more sources

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Biomedicines, 2022
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also
Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel   +11 more
doaj   +1 more source

Cyclosporine in Stevens-Johnson syndrome and toxic epidermal necrolysis: Experience from a tertiary care centre of South Rajasthan

Indian Dermatology Online Journal, 2021
Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous drug reactions with a high morbidity and mortality that require immediate medical care.
Manisha Balai, Manju Meena, Asit Mittal, Lalit Kumar Gupta, Ashok Kumar Khare, Sharad Mehta   +5 more
doaj   +1 more source

Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis

Acta Dermato-Venereologica, 2019
Psoriasis is considered to be a cytokine-driven immune-mediated disease, although the cell cytotoxicity mechanisms involved remain unrecognized. Herein, we analyzed granulysin expression in different lymphocyte subsets of peripheral blood of 40 psoriatic
Marijana Vičić, Marija Kaštelan, Vlatka Sotošek Tokmadžić, Larisa Prpić Massari   +3 more
doaj   +1 more source

Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells

BMC Immunology, 2007
Background Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells play an essential role in the host defence against intracellular pathogens such as Listeria, and Mycobacteria.
Wagner Carsten A, Dumrese Claudia, Sundstrom Hanna, Velic Ana, Latinovic-Golic Sonja, Walch Michael, Groscurth Peter, Ziegler Urs   +7 more
doaj   +1 more source

Diminished Systemic and Mycobacterial Antigen Specific Anti-microbial Peptide Responses in Low Body Mass Index–Latent Tuberculosis Co-morbidity

Frontiers in Cellular and Infection Microbiology, 2020
Low body mass index (BMI) is a risk factor for progression from latent Mycobacterium tuberculosis infection to active tuberculosis (TB) disease. Anti-microbial peptides (AMPs) are multifunctional molecules that play a crucial role in the mammalian host ...
Anuradha Rajamanickam, Saravanan Munisankar, Chandra Kumar Dolla, Subash Babu, Subash Babu   +4 more
doaj   +1 more source

Improved Purification of Human Granzyme A/B and Granulysin Using a Mammalian Expression System

Frontiers in Immunology, 2022
Cytotoxic lymphocytes release proteins contained within the cytoplasmic cytolytic granules after recognition of infected or tumor target cells. These cytotoxic granular proteins (namely granzymes, granulysin, and perforin) are key immunological mediators
Valerio Rasi, Valerio Rasi, Owais Abdul Hameed, Owais Abdul Hameed, Patricia Matthey, Sibes Bera, Duane P. Grandgenett, Stefan Salentinig, Michael Walch, Daniel F. Hoft, Daniel F. Hoft   +10 more
doaj   +1 more source

DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

Медицинская иммунология, 2018
Granulysin and cathelicidin, the cytolytic molecules of innate immune system are important protective factors during infection with Mycobacterium tuberculosis. We present original data concerning high levels of granulysin and cathelicidin among the group
M. M. (Jr) Averbakh, L. V. Panova, M. F. Gubkina, N. I. Evseeva   +3 more
doaj   +1 more source

Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates. [PDF]

PLoS Pathogens, 2013
Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown.
Crystal Y Chen, Shuyu Yao, Dan Huang, Huiyong Wei, Helene Sicard, Gucheng Zeng, Hassan Jomaa, Michelle H Larsen, William R Jacobs, Richard Wang, Norman Letvin, Yun Shen, Liyou Qiu, Ling Shen, Zheng W Chen   +14 more
doaj   +1 more source

A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin

Frontiers in Immunology, 2021
Malaria remains one of the most serious health problems in developing countries. The causative agent of malaria, Plasmodium spp., have a complex life cycle involving multiple developmental stages as well as different morphological, biochemical and ...
Maria Andrea Hernández-Castañeda, Marilyne Lavergne, Pierina Casanova, Bryan Nydegger, Carla Merten, Bibin Yesodha Subramanian, Patricia Matthey, Nils Lannes, Pierre-Yves Mantel, Michael Walch   +9 more
doaj   +1 more source