Results 1 to 10 of about 3,866 (172)
MBio, 2022 The cytotoxic granules of human NK and CD8 T cells contain the effector molecule granulysin. Although in vitro studies indicate that granulysin is bactericidal to Mycobacterium tuberculosis and human CD8 T cells restrict intracellular M.
Rujapak Sutiwisesak +2 more
exaly +3 more sources
Biology and clinical relevance of granulysin [PDF]
Tissue Antigens, 2009 AbstractGranulysin is a cytolytic and proinflammatory molecule first identified by a screen for genes expressed ‘late’ (3–5 days) after activation of human peripheral blood mononuclear cells. Granulysin is present in cytolytic granules of cytotoxic T lymphocytes and natural killer cells.
A M, Krensky, C, Clayberger
exaly +3 more sources
Perforin and Granulysin-Mediated Cytotoxicity in Colorectal Cancer Patients [PDF]
MedicinaBackground and Objectives: The incidence of colorectal cancer (CRC) in developed Western countries is constantly growing. CRC represents the third most common cancer and the second leading cancer-related cause of death worldwide.
Ludvig Letica +9 more
doaj +2 more sources
Granulysin: A Novel Host Defense Molecule [PDF]
American Journal of Transplantation, 2005 Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic ...
Alan M, Krensky, Carol, Clayberger
exaly +3 more sources
Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin
OncoImmunology, 2019 Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors.
Rocio Navarro +2 more
exaly +2 more sources
Granulysin: The attractive side of a natural born killer [PDF]
Immunology Letters, 2020 First discovered in the 1980's, granulysin has until recently been thought of solely as an effector molecule present within cytotoxic immune cell populations, and involved in the direct killing of pathogens and infected or transformed eukaryotic cells.
Sparrow, E, Bodman-Smith, MD
exaly +4 more sources
Plasma granulysin concentrations and preeclampsia risk [PDF]
Clinical Biochemistry, 2006 Epidemiological, clinical and histological data suggest intriguing similarities between preeclampsia and graft-host-rejection. Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection.
, Chunfang Qiu, Masatoshi Sakai
exaly +3 more sources
Cytotoxic Molecules as Potential Biomarkers for Active and Inactive Systemic Lupus Erythematosus [PDF]
BiomedicinesObjectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by persistent inflammation. Reliable biomarkers for predicting disease reactivation are lacking.
Paola Santana-Sánchez +8 more
doaj +2 more sources
Pinus roxburghii Constituents Augment Human Lymphocytes Mediated Cytotoxicity Towards Cancer Cells [PDF]
Pharmaceutical Sciences, 2021 Background: Pinus roxburghii has been used in the Himalayan region as folkloric remedy while nothing is yet known about its immunomodulatory potential.
Henok Gullilat +4 more
doaj +1 more source