Results 11 to 20 of about 3,866 (172)

Analysis of granulysin expression in vitiligo and halo-nevus

Scientific Reports
Vitiligo and halo nevus are immune-mediated skin diseases that have a similar pathogenesis and involve cellular cytotoxicity mechanisms that are not yet fully understood.
Nika Hlača, Marijana Vičić, Marija Kaštelan, Andrea Dekanić, Larisa Prpić-Massari   +4 more
doaj   +4 more sources

Upregulated serum granulysin levels in women with antiphospholipid antibody‐associated recurrent miscarriage are downregulated by heparin treatment

Reproductive Medicine and Biology, 2022
Purpose Granulysin is a cytotoxic protein that simultaneously activates innate and cellular immunity. The authors aimed to evaluate whether granulysin is associated with the antiphospholipid antibody syndrome and whether heparin changes the granulysin ...
Tomoko Ichikawa, Yasuyuki Negishi, Sayuri Kasano, Ryoko Yokote, Mirei Yonezawa, Nozomi Ouchi, Yoshimitsu Kuwabara, Shunji Suzuki, Toshiyuki Takeshita   +8 more
doaj   +1 more source

Hemolysis of Erythrocytes by Granulysin-Derived Peptides but Not by Granulysin [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACTGranulysin, a 9-kDa protein localized in human cytolytic T lymphoctyes and natural killer cell granules, is cytolytic against tumors and microbes but not against red blood cells. Synthetic peptides corresponding to the central region of granulysin recapitulate the lytic activity of the intact molecule, and some peptides cause hemolysis of red ...
Qing, Li, Chen, Dong, Anmei, Deng, Masao, Katsumata, Ari, Nakadai, Tomoyuki, Kawada, Satoshi, Okada, Carol, Clayberger, Alan M, Krensky   +8 more
openaire   +2 more sources

Granulysin-expressing CD4+ T cells as candidate immune marker for tuberculosis during childhood and adolescence. [PDF]

PLoS ONE, 2011
BACKGROUND: Granulysin produced by cytolytic T cells directly contributes to immune defense against tuberculosis (TB). We investigated granulysin as a candidate immune marker for childhood and adolescent TB.
Henrik Mueller, Kellen C Faé, Klaus Magdorf, Christian A Ganoza, Ulrich Wahn, Ute Guhlich, Cornelia Feiterna-Sperling, Stefan H E Kaufmann   +7 more
doaj   +1 more source

In vivo potential of recombinant granulysin against human melanoma

Cancer Treatment and Research Communications, 2021
9-kDa granulysin is a protein expressed into the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. It has been shown to exert cytolysis on microbes and tumors.
Sameer Al-Wasaby, Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Ruth Soler, Blanca Conde, Luis Martínez-Lostao, Alberto Anel   +6 more
doaj   +1 more source

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin. [PDF]

PLoS ONE, 2016
Granulysin, a cationic protein expressed by human natural killer cells and cytotoxic T lymphocytes, is a mediator for drug-induced Stevens-Johnson syndrome and graft-versus-host disease.
Hung-Mu Wei, Li-Chih Lin, Chiu-Feng Wang, Yi-Jang Lee, Yuan-Tsong Chen, You-Di Liao   +5 more
doaj   +1 more source

Trimethoprim/Sulfamethoxazole-Induced Systemic Toxic Epidermal Necrolysis Syndrome: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Trimethoprim/sulfamethoxazole can induce life‐threatening toxic epidermal necrolysis. Early recognition, immediate drug cessation, and multidisciplinary supportive care are critical. Even with aggressive therapy, mortality remains high, and SCORTEN score aids in prognostication.
Wang Q, Chen L, Ye W.
europepmc   +2 more sources

Granulysin expression and granulysin‑mediated apoptosis in the peripheral blood of osteoarthritis patients

Biomedical Reports, 2022
Osteoarthritis (OA) is a chronic joint disease caused by mechanical damage and metabolic factors that support the development of low-grade inflammation. Increased levels of T helper 1 pro-inflammatory cytokines in the serum of OA patients may support granulysin (GNLY) mediated cytotoxicity, which in-turn may contribute to the pathogenesis of OA. In the
Drvar, Vedrana, Ćurko-Cofek, Božena, Karleuša, Ljerka, Aralica, Merica, Rogoznica, Marija, Kehler, Tatjana, Legović, Dalen, Rukavina, Daniel, Laškarin, Gordana   +8 more
openaire   +4 more sources

Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox

Case Reports in Oncology, 2022
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL,
Mayuko Amagai, Sadanori Furudate, Kentaro Ohuchi, Toshiya Takahashi, Emi Yamazaki, Hiromu Chiba, Yoshihide Asano, Taku Fujimura   +7 more
doaj   +1 more source

IL-21 Selectively Augments Cytotoxic Potential of Antigen-Activated MAIT Cells. [PDF]

Eur J Immunol
Using an in vitro PBMC assay, we found that the addition of exogenous IL‐21 enhances the cytotoxic potential of MAIT cells activated by 5‐OP‐RU. IL‐21 induces STAT phosphorylation and provides co‐stimulation to TCR‐activated MAIT cells, selectively augmenting granzyme B and perforin expression without enhancing interferon‐gamma or TNF production at 6 h.
Wedlock LE, Lamichhane R, Webley MC, Gilmer SCL, Vernall AJ, Ussher JE.   +5 more
europepmc   +2 more sources