Results 31 to 40 of about 3,866 (172)

Coordinated In Vitro Release of Granulysin, Perforin and IFN-γ in TB and HIV/TB Co-Infection Associated with Clinical Outcomes before and after Anti-TB Treatment

Pathogens, 2020
Granule-associated killing molecules released from cytotoxic T lymphocytes participate as a crucial step in immunity against tuberculosis (TB), but the role of coordinated production remains controversial.
Nada Pitabut, Panadda Dhepakson, Shinsaku Sakurada, Naoto Keicho, Srisin Khusmith   +4 more
doaj   +1 more source

Clinical, biochemical, genetic, and therapeutic profile of patients with epidermal necrolysis: A descriptive study

Indian Journal of Dermatology, 2022
Background: Epidermal necrolysis (SJS/TEN) is a rare but acute severe drug reaction associated with high morbidity and mortality rates. Aims: To describe the clinical, molecular, biochemical, and therapeutic profile of these patients. Methods: A total of
Sushil K Sangwan, Neena Khanna, Namrata Sharma, Tushar Agarwal, Arundhati Sharma, Rasik B Vajpayee   +5 more
doaj   +1 more source

Decreased Expression of Cytotoxic Proteins in Decidual CD8⁺ T Cells in Preeclampsia

Biology, 2021
In our study, we aimed to establish expression of cytotoxic CD8+ T cells in the decidua basalis and the maternal peripheral blood (mPBL) of severe and mild preeclampsia (PE) and compare to healthy pregnancies.
Violeta Soljic, Maja Barbaric, Martina Vukoja, Marina Curlin, Martina Orlovic Vlaho, Edita Cerni Obrdalj, Lidija Lasic Arapovic, Daniela Bevanda Glibo, Katarina Vukojevic   +8 more
doaj   +1 more source

The Role of Granulysin in Cancer Immunology [PDF]

ISRN Immunology, 2012
Granulysin is a cytotoxic granule expressed in cytotoxic T cells and natural killer cells. Although its cytotoxic effect against a number of tumor cell lines has been demonstratedin vitro, recent studies with transgenic mice, and a number of clinical studies, have further established its significance in cancer immunology.
Satoshi Okada, Tetsuo Morishita
openaire   +1 more source

Profiles of Cytotoxic T Lymphocytes in Cutaneous Lymphoid Hyperplasia of the Face

Case Reports in Dermatology, 2013
Cutaneous lymphoid hyperplasia (CLH) is difficult to differentiate from primary malignant cutaneous lymphomas that may present as solitary nodules, and sometimes it requires much time to achieve a final diagnosis.
Sadanori Furudate, Taku Fujimura, Yumi Kambayashi, Setsuya Aiba   +3 more
doaj   +1 more source

Granulysin skin game [PDF]

Science-Business eXchange, 2008
Researchers in Taiwan have identified a cytotoxic protein, granulysin, that could be targeted to treat or diagnose Stevens-Johnson syndrome and related cutaneous eruptions caused by adverse drug reactions. Now in vivo experiments will need to validate the potential of the approach.
openaire   +1 more source

Expression, processing and transcriptional regulation of granulysin in short-term activated human lymphocytes

BMC Immunology, 2007
Background Granulysin, a cytotoxic protein expressed in human natural killer cells and activated T lymphocytes, exhibits cytolytic activity against a variety of intracellular microbes.
Groscurth Peter, Dumrese Claudia, Sundstrom Hanna, Walch Michael, Latinovic-Golic Sonja, Ziegler Urs   +5 more
doaj   +1 more source

Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin

Clinical and Developmental Immunology, 2012
During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin
Danijela Veljkovic Vujaklija, Sonja Sucic, Tamara Gulic, Marin Dominovic, Daniel Rukavina   +4 more
doaj   +1 more source

Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment.

PLoS ONE, 2017
BackgroundThe association of antimicrobial peptides (AMPs) with tuberculosis-diabetes comorbidity (PTB-DM) is not well understood.MethodsTo study the association of AMPs with PTB-DM, we examined the systemic levels of cathelicidin (LL37), human beta ...
Nathella Pavan Kumar, Kadar Moideen, Vijay Viswanathan, Shanmugam Sivakumar, Pradeep A Menon, Hardy Kornfeld, Subash Babu   +6 more
doaj   +1 more source

Biosynthesis of granulysin, a novel cytolytic molecule

Molecular Immunology, 1999
Granulysin is a newly described lytic molecule expressed by CTL and NK cells. Three mRNA (519, 520, and 522) and two protein products of 15 and 9 kDa are encoded by the granulysin gene. Stable transfectants overexpressing the predominate 520 mRNA were generated to determine the protein products originating from the translation of this message.
D A, Hanson, A A, Kaspar, F R, Poulain, A M, Krensky   +3 more
openaire   +2 more sources