Results 151 to 160 of about 53,350 (260)

Immune dysregulation in the prostates of C57BL/6Aire−/− mice mirrors that seen in human benign prostatic hyperplasia

The Journal of Pathology, EarlyView.
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman, Jiang Yang, Simon W Hayward, Timothy L Ratliff   +12 more
wiley   +1 more source

Granzyme B PET Imaging Uncovers Dynamic Patterns of Disease Activity and Therapeutic Response in a Murine Colitis Model. [PDF]

Int J Mol Sci
Haj-Mirzaian A, Ma M, Hofmann N, Yuan H, Mahmood U, Heidari P.   +5 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

SIRPγ limits effector differentiation of human CD8 T cells in response to subthreshold TCR-signaling. [PDF]

Immunohorizons
Morse M, Rodriguez X, Delarosa E, Rodriguez S, Shanil J, Sinha S.   +5 more
europepmc   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Mechanisms of paraneoplastic neurological syndromes. [PDF]

Curr Opin Neurol
Kunchok A, Vogrig A, Graus F.
europepmc   +1 more source

Granzyme K: A new frontier in systemic lupus erythematosus

Rheumatology &Autoimmunity, EarlyView.
The role of Granzyme K in the pathogenesis of systemic lupus erythematosus and its clinical translational significance. Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune disorder driven by dysregulated adaptive and innate immunity and aberrant complement activity.
Zhongyu Chen, Yunjing Pu, Peihui Yang, Qinghuan Zhu, Haojun Long, Danqi Deng   +5 more
wiley   +1 more source

Granzyme B-expressing regulatory B cells share the same origin as conventional blood B cells. [PDF]

Biochem Biophys Rep
Genebrier S, Sailliet N, Bastos Serra Trinca S, Le Mai H, Dupuy A, Cornic M, Danger R, Giral M, Tarte K, Brouard S, Cogné M.   +10 more
europepmc   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Protocol for mapping tumor infiltration by murine T cells using multiplex immunofluorescence. [PDF]

STAR Protoc
Lim RJ, Dumitras C, Krysan K, Tran LM, Man S, Dubinett SM, Liu B.   +6 more
europepmc   +1 more source