Results 51 to 60 of about 94,825 (337)

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

Vaginal Chlamydial Clearance Following Primary or Secondary Infection in Mice Occurs Independently of TNF-α

Frontiers in Cellular and Infection Microbiology, 2013
The role of TNF-α in chlamydial clearance is uncertain. Antibody-mediated depletion of TNF-α in mice and guinea pigs has been shown not to significantly affect chlamydial clearance, whereas production of TNF-α in addition to IFN-γ from T cells has been ...
Sangamithra eKamalakaran, Bharat eChaganty, Rishein eGupta, Rishein eGupta, M. Neal Guentzel, M. Neal Guentzel, James Patrick Chambers, James Patrick Chambers, Ashlesh eMurthy, Bernard eArulanandam, Bernard eArulanandam   +10 more
doaj   +1 more source

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection

iScience, 2023
Summary: There is great need for vaccines against tuberculosis (TB) more efficacious than the licensed BCG. Our goal was to identify new vaccine benchmarks by identifying immune responses that distinguish individuals able to eradicate the infection (TB ...
Emilie Jalbert, Cuining Liu, Vidya Mave, Nancy Lang, Anju Kagal, Chhaya Valvi, Mandar Paradkar, Nikhil Gupte, Rahul Lokhande, Renu Bharadwaj, Vandana Kulkarni, Amita Gupta, Adriana Weinberg   +12 more
doaj   +1 more source

Granzyme A in Chikungunya and Other Arboviral Infections

Frontiers in Immunology, 2020
Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation.
Alessandra Soares-Schanoski, T. Le, D. Kaiserman, C. Rowe, N. Prow, Diego D. Barboza, C. Santos, P. Zanotto, K. Magalhães, L. Aurelio, D. Muller, P. Young, P. Zhao, P. Bird, A. Suhrbier   +14 more
semanticscholar   +1 more source

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

γδ T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage

Journal of Immunology, 2020
Key Points γδ T cells expand and develop cytolytic potential in response to malaria cultures. γδ T cells inhibit parasite growth in a contact- and granzyme-dependent manner.
M. A. Hernández-Castañeda, Katharina Happ, Filippo Cattalani, A. Wallimann, M. Blanchard, I. Fellay, B. Scolari, Nils Lannes, S. Mbagwu, B. Fellay, L. Filgueira, P. Mantel, M. Walch   +12 more
semanticscholar   +1 more source

Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas. [PDF]

, 2017
Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous ...
Duvic, Madeleine, Girardi, Michael, Guitart, Joan, Ivan, Doina S, Junkins-Hopkins, Jacqueline, Kim, Ellen, Kim, Jinah, Kim, Youn H, Martinez-Escala, M Estela, Olsen, Elise A, Pincus, Laura B, Pulitzer, Melissa P, Rook, Alain H, Sable, Kimberly A, Samimi, Sara S, Selim, M Angelica, Subtil, Antonio, Tetzlaff, Michael T, Virmani, Pooja, Wood, Gary S   +19 more
core   +1 more source

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo. [PDF]

PLoS ONE, 2016
Granzyme A, a serine protease expressed in the granules of cytotoxic T and Natural Killer cells, is involved in the generation of pro-inflammatory cytokines by macrophages. Granzyme A has been described to induce in macrophages in vitro the activation of
Santiago Uranga, Dessislava Marinova, Carlos Martin, Julián Pardo, Nacho Aguilo   +4 more
doaj   +1 more source

Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response

Journal for ImmunoTherapy of Cancer, 2020
Background Cancer immunotherapy research is expanding to include a more robust understanding of the mechanisms of treatment response and resistance. Identification of drivers of pro-tumor and anti-tumor immunity during treatment offers new strategies for
Thomas J. LaSalle, Emily E Austin, Grant Rigney, E. Wehrenberg-Klee, Sarah Nesti, B. Larimer, U. Mahmood   +6 more
semanticscholar   +1 more source

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu, A Kadioglu, A Nalbant, A Strasser, AD Badley, Andrea M. Mitchell, C Riccardi, CA Janeway Jr, CK Sung, D Zhou, David H. Dockrell, DH Dockrell, DH Dockrell, DH Dockrell, DR Cundell, EE McGrath, FK Swirski, Frank R. DeLeo, G Matute-Bello, Helen M. Marriott, HM Marriott, HM Marriott, I Nicoletti, J Warwick-Davies, JA Carrero, Julie A. Preston, K Beiter, K Kemp, K LeMessurier, KA Browne, KE Price, L Galluzzi, L Maggi, L Ziegler-Heitbrock, LA Kirkham, M Daigneault, M Lenardo, M Witzenrath, MA Barocchi, MA Bewley, Marc Daigneault, Martin A. Bewley, MJ Jedrzejas, Moira K. B. Whyte, N Olivares-Zavaleta, N Oyaizu, NV Serbina, PA Kiener, R Malley, RA Hirst, Robert C. Read, RS Hotchkiss, RS Hotchkiss, RS Hotchkiss, SE Weber, SJ Webster, SL Newman, T Mattern, T Takahashi, Thushan I. De Silva, Timothy J. Mitchell, WL Farrar, WP Hausdorff, YJ Lu, Z Zhang   +64 more
core   +4 more sources