Results 1 to 10 of about 78,129 (305)

Granzyme B in Autoimmune Skin Disease [PDF]

Biomolecules, 2023
Autoimmune diseases often present with cutaneous symptoms that contribute to dysfunction, disfigurement, and in many cases, reduced quality-of-life. Unfortunately, treatment options for many autoimmune skin diseases are limited.
Anna Gleave, David J. Granville
doaj   +4 more sources

Induction Therapies Determine the Distribution of Perforin and Granzyme B Transcripts in Kidney Transplant Recipients [PDF]

Biomedicines
Peripheral blood mononuclear cells contain secretory granules with Perforin and Granzyme B for defense against pathogens. The objective of the present study was to compare the effects of immunosuppressive induction therapies on Perforin and Granzyme B ...
Dino Pipic, Marianne Rasmussen, Qais W. Saleh, Martin Tepel   +3 more
doaj   +2 more sources

Diagnostic Efficacy and Clinical Significance of Lymphocyte Subsets, Granzyme B and Perforin in the Peripheral Blood of Patients with Invasive Breast Cancer Following Neoadjuvant Chemotherapy [PDF]

Cancer Management and Research
Purpose: Breast cancer, a predominant contributor to cancer-related mortality worldwide, is increasingly managed through the application of neoadjuvant chemotherapy (NAC).
Liu H, Zheng R, Zhuang Z, Xue L, Chen M, Wu Y, Zeng Y   +6 more
doaj   +2 more sources

Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment

Frontiers in Immunology, 2021
Granzyme B is a renowned effector molecule primarily utilized by CTLs and NK cells against ill-defined and/or transformed cells during immunosurveillance.
Weinan Wang, Rui Zou, Ye Qiu, Jishuang Liu, Yu Xin, Tianzhu He, Tianzhu He, Zhidong Qiu   +7 more
doaj   +1 more source

Lower Circulating Cytotoxic T-Cell Frequency and Higher Intragraft Granzyme-B Expression Are Associated with Inflammatory Interstitial Fibrosis and Tubular Atrophy in Renal Allograft Recipients

Medicina, 2023
Background and Objectives: Inflammatory interstitial fibrosis and tubular atrophy (i-IFTA) is an inflammation in the area of tubular atrophy and fibrosis.
Brijesh Yadav, Narayan Prasad, Vinita Agrawal, Vikas Agarwal, Manoj Jain   +4 more
doaj   +1 more source

Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. [PDF]

PLoS ONE, 2012
Pancreatic beta cell destruction in type 1 diabetes is mediated by cytotoxic CD8(+) T lymphoctyes (CTL). Granzyme B is an effector molecule used by CTL to kill target cells.
Zia U Mollah, Kate L Graham, Balasubramanian Krishnamurthy, Prerak Trivedi, Thomas C Brodnicki, Joseph A Trapani, Thomas W Kay, Helen E Thomas   +7 more
doaj   +1 more source

Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination

Viruses, 2021
Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs).
Naruhito Otani, Kazuhiko Nakajima, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Yoshio Takesue, Takuma Yamamoto, Susumu Tanimura, Masayuki Shima, Toshiomi Okuno   +9 more
doaj   +1 more source

NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

Cell Reports, 2023
Summary: Genital herpes is characterized by recurrent episodes of epithelial blistering. The mechanisms causing this pathology are ill defined. Using a mouse model of vaginal herpes simplex virus 2 (HSV-2) infection, we show that interleukin-18 (IL-18 ...
Ying Shiang Lim, Aisha G. Lee, Xiaoping Jiang, Jason M. Scott, Adjoa Cofie, Sandeep Kumar, Dania Kennedy, David J. Granville, Haina Shin   +8 more
doaj   +1 more source

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection

iScience, 2023
Summary: There is great need for vaccines against tuberculosis (TB) more efficacious than the licensed BCG. Our goal was to identify new vaccine benchmarks by identifying immune responses that distinguish individuals able to eradicate the infection (TB ...
Emilie Jalbert, Cuining Liu, Vidya Mave, Nancy Lang, Anju Kagal, Chhaya Valvi, Mandar Paradkar, Nikhil Gupte, Rahul Lokhande, Renu Bharadwaj, Vandana Kulkarni, Amita Gupta, Adriana Weinberg   +12 more
doaj   +1 more source

Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. [PDF]

PLoS ONE, 2013
The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation.
Paul R Hiebert, Wendy A Boivin, Hongyan Zhao, Bruce M McManus, David J Granville   +4 more
doaj   +1 more source