Results 11 to 20 of about 78,129 (305)

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
AL Rerole, Alan G. Pockley, Andreas Kirschner, Axel Walch, Brigitte T. Doß, C Botzler, C Botzler, C Gross, D Kaiserman, D Schilling, DR Ciocca, E Schmitt, FC Kurschus, G MacDonald, G Multhoff, G Multhoff, Gabriele Multhoff, Gemma A. Foulds, H Dertinger, J Friedrich, J Friedrich, J Nylandsted, J Sun, J Thiery, JA Trapani, K Pfister, L Chavez-Galan, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Wang, Mathias Gehrmann, Michael Platten, MS Buzza, RZ Lin, S Balkow, S Mahrus, S Stangl, S Stangl, SP Cullen, Stefan Stangl, SW Krause, U Giesubel, V Milani, WA Boivin, Wolfgang Sievert, Y Liu, Y Liu, Z Xia   +50 more
core   +12 more sources

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins [PDF]

, 1993
The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise ...
Borst, Jannie, Brakenhoff, Just P.J., Hack, C. Erik, Kamp, Angela M., Kummer, J. Alain, Radosevic, K., Radosevic, Katarina, van Katwijk, Marcel, van Leeuwen, Anne Marie, Verweij, Cornelis L.   +9 more
core   +10 more sources

Dual roles of granzyme B [PDF]

Scandinavian Journal of Immunology, 2021
AbstractGranzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB; for example, it is an aetiology and a factor responsible for the aggravation of several ...
Huiling Wang, Yong Huang, Jian He, Liping Zhong, Yongxiang Zhao   +4 more
openaire   +1 more source

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

Elevated serum granzyme B levels are associated with disease activity and joint damage in patients with rheumatoid arthritis

Journal of International Medical Research, 2020
Objectives Little is known about the roles of granzyme B in rheumatoid arthritis (RA). We aimed to evaluate the serum level of granzyme B in patients with RA and determine relationships with clinical features and joint destruction of RA.
Junjie Qiao, Meng Zhou, Zheng Li, Jie Ren, Guanghan Gao, Jumei Zhen, Guanglei Cao, Lixiang Ding   +7 more
doaj   +1 more source

Granzyme B PET Imaging of the Innate Immune Response

Molecules, 2020
The human immune system is a complex system which protects against invaders and maintains tissue homeostasis. It is broadly divided into the innate and adaptive branches. Granzyme B is serine protease that plays an important role in both and can serve as
Kathleen M. Capaccione, Mikhail Doubrovin, Nikunj Bhatt, Akiva Mintz, Andrei Molotkov   +4 more
doaj   +1 more source

NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells

Frontiers in Immunology, 2021
Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant ...
Yorleny Vicioso, Derek P. Wong, Nand K. Roy, Nayanika Das, Keman Zhang, Parameswaran Ramakrishnan, Parameswaran Ramakrishnan, Reshmi Parameswaran, Reshmi Parameswaran   +8 more
doaj   +1 more source

Study of serum Granzyme B in heavy cigarette smokers with and without chronic obstructive pulmonary disease

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Inflammation of the airways is present in COPD with increased number of inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis in which secreted molecules such as granzymes form pores in the ...
Ahmed A. Yousef, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source

Study of effect of inhaled versus oral corticosteroids on sputum granzyme B in patients with moderate persistent bronchial asthma

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Background: Asthma is a major public health problem with a high economic burden. It involves several inflammatory cells and multiple mediators. Granzyme B is an inflammatory mediator expressed and secreted by both immune and non immune cells. Recently it
Walaa K. Shoeib, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source

Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors

iScience, 2020
Summary: Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to ...
Diego López León, Patricia Matthey, Isabelle Fellay, Marianne Blanchard, Denis Martinvalet, Pierre-Yves Mantel, Luis Filgueira, Michael Walch   +7 more
doaj   +1 more source