Results 81 to 90 of about 933 (174)

Capsid structure of dsRNA fungal viruses [PDF]

, 2018
Most fungal, double-stranded (ds) RNA viruses lack an extracellular life cycle stage and are transmitted by cytoplasmic interchange. dsRNA mycovirus capsids are based on a 120-subunit T = 1 capsid, with a dimer as the asymmetric unit.
Castón, JR, Ghabrial, SA, Luque Buzo, Daniel , Luque, D, Mata, CP, Suzuki, N   +5 more
core   +5 more sources

Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses. [PDF]

PLoS Pathog
While robust interferon (IFN) responses in fish are critical for viral clearance, dysregulated signalling can trigger detrimental hyperinflammation, necessitating precise immunoregulatory mechanisms. This study identified Toll-interacting protein (TOLLIP)
Tian MZ, Wang YY, Cui BJ, Xu X, Zhou CJ, Zhang C, Li ZC, Hong MQ, Xu N, Chen DD, Lu LF, Li S.   +11 more
europepmc   +2 more sources

Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication. [PDF]

Front Immunol
Similar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Li JQ, Zhang J, Chen Y, Le T, Chang MX.
europepmc   +2 more sources

Functional investigation of grass carp reovirus nonstructural protein NS80 [PDF]

, 2011
Background Grass Carp Reovirus (GCRV), a highly virulent agent of aquatic animals, has an eleven segmented dsRNA genome encased in a multilayered capsid shell, which encodes twelve proteins including seven structural proteins (VP1-VP7), and ...
Lin Cai, Xiaoyun Sun, Ling Shao, Qin Fang   +3 more
core   +2 more sources

Large-scale SNP screenings identify markers linked with GCRV resistant traits through transcriptomes of individuals and cell lines in Ctenopharyngodon idella

Scientific Reports, 2017
Grass carp (Ctenopharyngodon idella) is an important economic species in freshwater aquaculture and its industry has been confined due to variety degeneration and frequent diseases. Marker-assisted selection is a feasible method for selective breeding of
Zhiwei Liao, Quanyuan Wan, Xueying Shang, Jianguo Su   +3 more
doaj   +1 more source

Signatures of dysbiosis in fish microbiomes in the context of aquaculture

Reviews in Aquaculture, Volume 16, Issue 2, Page 706-731, March 2024.
Fish gut microbiome is highly susceptible to salinity changes and antimicrobial treatments, whereas external microbiomes seem to be more susceptible to disease and variations in temperature. Treatments with tetracyclines and florfenicol, as well as bacterial diseases, prompt severe dysbiosis, whereas quinolones, disinfectants and parasitic diseases ...
Raquel Xavier, Ricardo Severino, Sofia M. Silva   +2 more
wiley   +1 more source

The effects of GCRV on various tissues of grass carp (Ctenopharyngodon idella) and identification of differential interferon-stimulating genes (ISGs) through muscle transcriptome analysis

Ecotoxicology and Environmental Safety
Grass carp hemorrhagic disease is caused by the grass carp reovirus (GCRV). The disease spreads rapidly and has a high fatality rate, which seriously affects grass carp culture. Moreover, the molecular mechanisms underlying grass carp hemorrhagic disease
Ziquan Yang, Huimei Zhang, Ziming Yuan, Jie Chen, Guodong Zheng, Shuming Zou   +5 more
doaj   +1 more source

Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review [PDF]

, 2019
Teleost fish, as with other vertebrates, rely on their innate immune system as a first line of defense against invading pathogens. A very important characteristic of the innate immune response is its ability to recognize conserved molecular structures ...
Jassy Mary S. Lazarte, Kim D. Thompson, Tae Sung Jung   +2 more
core   +1 more source

VP4/VP56/VP35 Virus-like Particles Effectively Protect Grass Carp (Ctenopharyngodon idella) against GCRV-II Infection

Vaccines, 2023
Grass carp reovirus (GCRV) seriously threatens the grass carp (Ctenopharyngodon idella) industry. Prophylactic GCRV vaccines prepared by virus-like particle (VLP) assembly biotechnology can improve effectiveness and safety.
Qingqing Tian, Xingchen Huo, Qian Liu, Chunrong Yang, Yongan Zhang, Jianguo Su   +5 more
doaj   +1 more source

Comparative Transcriptomics Analysis Reveals Unique Immune Response to Grass Carp Reovirus Infection in Barbel Chub (Squaliobarbus curriculus). [PDF]

Biology (Basel)
Grass carp (Ctenopharyngodon idella) and barbel chub (Squaliobarbus curriculus)—both Leuciscinae subfamily species—demonstrate differences in grass carp reovirus (GCRV) infection resistance.
Huang Y, Wang X, Lv Z, Hu X, Xu B, Yang H, Xiao T, Liu Q.   +7 more
europepmc   +2 more sources