TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition. [PDF]
Adv Sci (Weinh)This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Zhang Y +16 more
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Journal of ophthalmic nursing & technology, 1990 Graves' disease is an inflammatory condition affecting the thyroid gland and the eye. The triad of exophthalmos, goiter, and hyperthyroidism is classic Graves' disease. Each of the signs may appear in an individual patient, although separated by weeks, months, or years.
R P, Yeatts, D M, Clontz
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Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength [PDF]
, 2020 Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development.
Becker, Niels-Peter +7 more
core +1 more source
Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]
, 1996 To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Heufelder, Armin E. +2 more
core +1 more source
Extraocular muscle sampled volume in Graves' orbitopathy using 3-T fast spin-echo MRI with iterative decomposition of water and fat sequences [PDF]
, 2018 Background: Current magnetic resonance imaging (MRI) techniques for measuring extraocular muscle (EOM) volume enlargement are not ideally suited for routine follow-up of Graves’ ophthalmopathy (GO) because the difficulty of segmenting the muscles at ...
BRUSCOLINI, ALICE +4 more
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A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]
, 1994 Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S. +3 more
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Prognostic indicators for the development of strabismus among patients with graves’ ophthalmopathy
Journal of Clinical & Translational Endocrinology, 2017 Objective: Thyroid eye disease (TED), an autoimmune inflammatory process involving the orbital tissues around the eye, is the most common extra-thyroidal manifestation of Graves’ disease (GD). Due to changes in the patient’s appearance, TED is a socially
Tiffany Y. Lin +4 more
doaj +1 more source
The thickness of the retrobulbar portion of the optic nerve in Graves ophthalmopathy measured by ultrasound [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2009 Introduction. The clinical diagnostic of Graves ophthalmopathy is based on the association of ocular signs and the disease of the thyroid gland. The evolution of the disease involves the development of eye globe protrusion, extraocular muscle thickening ...
Stefanović Ivan +3 more
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HUBUNGAN FAKTOR RISIKO TERHADAP KEJADIAN OPHTHALMOPATHY GRAVES
Jurnal Kedokteran Diponegoro, 2019 Latar Belakang: Opthalmopathy Graves merupakan salah satu tanda adanya penyakit Graves; penyakit autoimun dengan inflamasi sistemik. OG bisa terjadi pada penyakit Graves yang fungsi tiroidnya hipertiroidisme, eutiroidisme dan hipotiroidisme.
Y. Andressa Nugroho W. +2 more
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Preventing Graves' Ophthalmopathy [PDF]
New England Journal of Medicine, 1998 Graves' ophthalmopathy and Graves' hyperthyroidism are closely linked, but the precise relation between these different expressions of the same disease is poorly understood.
openaire +3 more sources