Results 141 to 150 of about 2,063,448 (396)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

open access: yesAdvanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu   +12 more
wiley   +1 more source

Influence of Different Shaping Techniques on the Aroma Quality and Volatile Metabolites of Green Tea Revealed by Gas Chromatography Electronic Nose and Gas Chromatography–Tandem Mass Spectrometry

open access: yesFoods
The shaping process is recognized as a crucial step in the manufacturing of green tea. However, its influence on aroma quality remains unclear. In this study, the effects of four shaping techniques, including flat green tea (FGT), straight green tea (SGT)
Jiahao Tang   +7 more
doaj   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

Self‐Activating Electrocatalysts for Water Splitting: Advancing Structure–Performance Understanding and Beyond

open access: yesAdvanced Energy Materials, EarlyView.
Self‐activating electrocatalysts offer strong potential for advanced water splitting, enabled by their dynamic compositional and structural evolution during operation. This review highlights recent advances in self‐activating OER and HER catalysts, emphasizing the driving forces and mechanisms underlying their adaptive behavior. A conceptual network of
Christean Nickel   +6 more
wiley   +1 more source

Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats

open access: yes, 2010
Excess carbohydrate in the diet may initiate a chronic state of oxidative stress exacerbating the clinical and biochemical symptoms of diet-induced type 2 diabetes, especially glucose intolerance, lipid abnormalities and cardiovascular complications ...
Rickman, Celestine   +3 more
core  

The Cost of a Nutritious Diet in Cafeterias: Evidence From US Military Dining Facilities

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Providing nutritious meals in institutional settings with financial constraints, such as military dining facilities, is challenging. The US Department of War (DoW) and US Department of Agriculture (USDA) collaborated to modernize the Basic Daily Food Allowance (BDFA) using an optimization model that incorporates service members' consumption ...
Linlin Fan   +8 more
wiley   +1 more source

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