Results 171 to 180 of about 6,551 (208)

Distinct Phosphorylation Patterns of AT1R by Biased Ligands and GRK Subtypes. [PDF]

Int J Mol Sci
Zhang Z, Liu C, Gong J, Su C, Liu Z, Li J, Zhang H.   +6 more
europepmc   +1 more source

Comprehensive evaluation of AlphaFold/OpenFold prediction of experimentally unresolved proteins through novel metrics. [PDF]

Brief Bioinform
Díaz FR, Orschanski D, Folco JI, Ceci JE, Nibeyro G, Robles Vega H, Nicola JP, Fernández EA.   +7 more
europepmc   +1 more source

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.

Cell Rep
Baker MJ, Hampson E, Islam P, Moral RP, Maunders EA, Hornigold K, Tsonou E, Malliri A, Hornigold DC, Hubbard RE, Massey AJ, Welch HCE.   +11 more
europepmc   +1 more source

Age-dependent impairment of dopamine D1 receptor signalling in mouse striatum by <i>FMR1</i> variant P626L. [PDF]

Brain Commun
Fu J, Jiang W, Shen L, Fu J, Duan X, Liu D, Long J, Ye S, Tang L, Yi YH, Long YS.   +10 more
europepmc   +1 more source

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy [PDF]

Journal of Cardiovascular Translational Research, 2015
G protein coupled receptor kinase type 2 (GRK2) plays an important role in the development and maintenance of cardiac hypertrophy and heart failure even if its exact role is still unknown.
Jessica Gambardella, Bruno Trimarco, Pietro Campiglia   +2 more
exaly   +8 more sources

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GRK2 at the Control Shaft of Cellular Metabolism

Current Pharmaceutical Design, 2012
G protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-cardiac diseases. Later discoveries,
CICCARELLI, Michele, E. Cipolletta, IACCARINO, Guido   +2 more
openaire   +5 more sources

Abstract 166: Identification of Grk2 as novel oncology target and development of potent Grk2 inhibitors

Cancer Research, 2022
Abstract G Protein-Coupled Receptor Kinase 2 (Grk2) is a serine-threonine kinase widely expressed in the human body. The GRK family of kinases is known for its role in GPCR phosphorylation and desensitization upon GPCR activation by agonists.
Alexandra Lantermann, Eugene Chekler, Bruce Lefker, Garmen Yuen, Vanessa Lam, Matthew Strickland, Justyne Pennacchio, Aaron Fulgham, Dara Bree, Thomas Perekslis, Grazia Piizzi, Hongyue Dai, Tim Zheng, John Wagner, Pearl Huang   +14 more
openaire   +1 more source

GRK2-Dependent Desensitization Downstream of G Proteins

Journal of Receptors and Signal Transduction, 2008
G protein-coupled receptor kinases (GRKs) are serine/threonine kinases first discovered by its role in receptor desensitization. Phosphorylation of the C-terminal tail of GPCRs by GRKs triggers the docking of beta-arrestins and the functional uncoupling of G proteins and receptors. In addition, we and others have uncovered new direct ways by which GRKs
M, Jurado-Pueyo, P M, Campos, F, Mayor, C, Murga   +3 more
openaire   +2 more sources

GRK2, a novel regulator of skeletal development

The FASEB Journal, 2022
STUDY OBJECTIVE During skeletal development, the cartilaginous growth plate (GP) allows for bone elongation, composed of chondrocytes organized into three histological zones: resting (RZ), proliferative (PZ), and hypertrophic (HZ).
Natalie K. Yoshioka, Vengadeshprabhu Karuppagounder, William J. Pinamont, Gina M. Deiter, Reyad A. Elbarbary, Maurizio Pacifici, Fadia Kamal   +6 more
openaire   +1 more source

GPCR activation and GRK2 assembly by a biased intracellular agonist

Nature, 2023
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated by biased ligands1-6. The molecular assembly of GRKs on GPCRs and the basis of GRK-mediated biased signalling remain largely unknown owing to the weak GPCR-GRK interactions.
Jia Duan, Heng Liu, Fenghui Zhao, Qingning Yuan, Yujie Ji, Xiaoqing Cai, Xinheng He, Xinzhu Li, Junrui Li, Kai Wu, Tianyu Gao, Shengnan Zhu, Shi Lin, Ming-Wei Wang, Xi Cheng, Wanchao Yin, Yi Jiang, Dehua Yang, H. Eric Xu   +18 more
openaire   +2 more sources