Results 191 to 200 of about 9,380 (213)

GRK2-Dependent Desensitization Downstream of G Proteins

Journal of Receptors and Signal Transduction, 2008
G protein-coupled receptor kinases (GRKs) are serine/threonine kinases first discovered by its role in receptor desensitization. Phosphorylation of the C-terminal tail of GPCRs by GRKs triggers the docking of beta-arrestins and the functional uncoupling of G proteins and receptors. In addition, we and others have uncovered new direct ways by which GRKs
M, Jurado-Pueyo, P M, Campos, F, Mayor, C, Murga   +3 more
openaire   +2 more sources

Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes

Cellular and Molecular Neurobiology, 2012
We previously demonstrated that in astrocytes, SDF-1/CXCL12 exclusively signals through CXCR7 despite the additional presence of the alternate SDF-1/CXCL12 receptor, CXCR4. In addition, we provided evidence that astrocytic CXCR7-signalling involves a G protein-dependent mechanism.
Jana, Lipfert, Veysel, Ödemis, Jürgen, Engele   +2 more
openaire   +2 more sources

GRK2 in cardiovascular disease and its potential as a therapeutic target

Journal of Molecular and Cellular Cardiology, 2022
Cardiovascular diseases (CVDs) represent the leading cause of death globally. Despite major advances in the field of pharmacological CVD treatments, particularly in the field of heart failure (HF) research, case numbers and overall mortality remain high and have trended upwards over the last few years.
Kimberly M, Ferrero, Walter J, Koch
openaire   +2 more sources

Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC₂ receptors in smooth muscle

American Journal of Physiology-Cell Physiology, 2008
The smooth muscle of the gut expresses mainly Gs protein-coupled vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptors (VPAC2 receptors), which belong to the secretin family of G protein-coupled receptors.
Karnam S, Murthy, Sunila, Mahavadi, Jiean, Huang, Huiping, Zhou, Wimolpak, Sriwai   +4 more
openaire   +2 more sources

A GRK2 peptide prevents heart failure

Science, 2016
Cardiovascular Biology During cardiac hypertrophy, sustained high blood pressure causes the heart walls to thicken to deal with the increased load. If left unchecked, cardiac hypertrophy leads to heart failure. A particular part of the kinase and scaffolding protein GRK2 inhibits a G protein that promotes cardiac hypertrophy.
openaire   +1 more source

Exploring the potential biological function of GRK2 in colorectal cancer

Functional & Integrative Genomics
Colorectal cancer (CRC) is a malignant tumor of the gastrointestinal tract with high morbidity and mortality. There is growing evidence that GRK2 plays a key role in the development and progression of several human cancers. However, the role and potential mechanisms of GRK2 in colon cancer (COAD) are unclear.The expression data of GRK2 was downloaded ...
Meng, Gao, Xinyi, Liang, Mengqi, Fan, Yutong, Wu, Ming-You, Dong, Run-Lei, Du   +5 more
openaire   +2 more sources

GRK2 Gene

2020
openaire   +1 more source

Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis

Frontiers in Immunology, 2021
Chenchen Han, Wei Wei
exaly  

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels

Journal of Molecular and Cellular Cardiology, 2015
Priscila Y Sato, Jessica Ibetti, Alessandro Cannavo   +2 more
exaly  

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

Cellular and Molecular Life Sciences, 2019
Petronila Penela Marquez, Catalina Ribas Nuñez, Francisco Sánchez-Madrid   +2 more
exaly