Results 181 to 190 of about 6,551 (208)

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2

Biochemical and Biophysical Research Communications, 2007
Epithelial Na(+) channels (ENaC) mediate the transport of sodium (Na) across epithelia in the kidney, gut, and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, which bind to proline-rich motifs (PY motifs) present in the C-termini of ENaC subunits. Loss of inhibition leads
Sanchez-Perez, A., Kumar, S., Cook, D.
openaire   +3 more sources

Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes

Cellular and Molecular Neurobiology, 2012
We previously demonstrated that in astrocytes, SDF-1/CXCL12 exclusively signals through CXCR7 despite the additional presence of the alternate SDF-1/CXCL12 receptor, CXCR4. In addition, we provided evidence that astrocytic CXCR7-signalling involves a G protein-dependent mechanism.
Jana, Lipfert, Veysel, Ödemis, Jürgen, Engele   +2 more
openaire   +2 more sources

Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC₂ receptors in smooth muscle

American Journal of Physiology-Cell Physiology, 2008
The smooth muscle of the gut expresses mainly Gs protein-coupled vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptors (VPAC2 receptors), which belong to the secretin family of G protein-coupled receptors.
Karnam S, Murthy, Sunila, Mahavadi, Jiean, Huang, Huiping, Zhou, Wimolpak, Sriwai   +4 more
openaire   +2 more sources

A GRK2 peptide prevents heart failure

Science, 2016
Cardiovascular Biology During cardiac hypertrophy, sustained high blood pressure causes the heart walls to thicken to deal with the increased load. If left unchecked, cardiac hypertrophy leads to heart failure. A particular part of the kinase and scaffolding protein GRK2 inhibits a G protein that promotes cardiac hypertrophy.
openaire   +1 more source

GRK2 Gene

2020
openaire   +1 more source

Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis

Frontiers in Immunology, 2021
Chenchen Han, Wei Wei, Jiajie Kuai
exaly  

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels

Journal of Molecular and Cellular Cardiology, 2015
Jessica Ibetti, Alessandro Cannavo, Walter J. Koch   +2 more
exaly  

GRK2 INHIBITORS AND USES THEREOF

2023
PIIZZI GRAZIA, CHEKLER EUGENE LVOVICH PIATNITSKI, HUROV JONATHAN BARRY, LANTERMANN ALEXANDRA, COUTO KILEY MARIE, XU HUA, SARKER SOURAV   +6 more
openaire   +3 more sources

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

Cellular and Molecular Life Sciences, 2019
Francisco Sánchez Madrid, Catalina Ribas, Federico Mayor Menéndez   +2 more
exaly  

Increased Nitric Oxide Bioavailability in Adult GRK2 Hemizygous Mice Protects Against Angiotensin II–Induced Hypertension

Hypertension, 2014
María S Avendaño, Ana Briones, Rocio Vila-Bedmar   +2 more
exaly