Results 121 to 130 of about 22,140 (207)

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu, Nur Mohammad, Fahad Ahmed, Towsif Alam, Koushik Saha, Durga Shahi, Adib Hossain, Mia Md. Tofayel Gonee Manik, Mst. Rina Parvin   +8 more
wiley   +1 more source

Humanized mice carrying a pathogenic GRN deletion as a pre-clinical platform for targeted gene therapies in frontotemporal dementia

Neurobiology of Disease
Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and changes to patient behaviour. Haploinsufficiency of the gene progranulin (GRN) is a major cause of FTD, for which there are no effective therapies.
Benjamin E. Life, Pardis Kazemian, Terri L. Petkau, Alissandra de Moura Gomes, Sarah B. Thomson, Ning Shen, Junia Myung, Farah Jayousi, Tess C. Lengyell, Philipp F. Lange, Elizabeth M. Simpson, Keegan Korthauer, Blair R. Leavitt   +12 more
doaj   +1 more source

Lithium Dispensing Patterns in Dutch Youth: Prevalence, Incidence Dosages, and Duration of Use From 2011 to 2022

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objective Bipolar disorder (BD) often emerges during mid‐adolescence and young adulthood, and leads to functional and social impairment, with a prevalence of 0.87% among Dutch youth. Lithium, the first‐line BD maintenance treatment, stabilizes mood, prevents suicide, and is well tolerated, yet its use has declined as long‐term second ...
Ravish N. Gangapersad, Lisa T. Ringeling, Jens H. J. Bos, Birgit C. P. Koch, Manon H. J. Hillegers, Pilar Garcia‐Gomez, Catharina C. M. Schuiling‐Veninga, Eelko Hak, Bram Dierckx   +8 more
wiley   +1 more source

Impact of Antiviral Therapy Scale‐Up Among People Who Inject Drugs in Scotland: Regional Evidence of Hepatitis C Virus Elimination

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background Expansion of highly effective direct‐acting antiviral (DAA) treatment for people who inject drugs (PWID) is regarded as essential to achieve hepatitis C virus (HCV) elimination. A decade since the introduction of DAA treatment, we aimed to assess its roll‐out and associated impact in reducing HCV prevalence among PWID in Scotland ...
Norah E. Palmateer, Pantelis Samartsidis, Christopher Biggam, Andrew McAuley, Scott A. McDonald, John Dillon, Stephen T. Barclay, Samantha J. Shepherd, Rory N. Gunson, Monica Desai, Duncan McCormick, Daniela De Angelis, Matthew Hickman, Sharon J. Hutchinson   +13 more
wiley   +1 more source

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Heather Wilkins, Sai Sruthi Amirtha Ganesh, Julia Draper, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley   +15 more
wiley   +1 more source

Neuropathology‐specific language features in primary progressive aphasia

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Primary Progressive Aphasia (PPA) clinical syndromes do not align consistently with underlying pathology. This study aimed to identify language markers for specific neuropathologies using both standard clinical tests and narrative speech analysis.
Jane Stocks, Elena Barbieri, Michelle Anne Los, Cynthia K. Thompson, Tamar Gefen, Changiz Geula, M.‐Marsel Mesulam, Sandra Weintraub   +7 more
wiley   +1 more source

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION The impact of different neuropathologies on deep brain structures remains to be understood. We examine subcortical and limbic volumetry in neurodegenerative diseases involving phosphorylated tau (p‐tau), α‐synuclein, and transactive response DNA binding protein 43 (TDP‐43).
Pulkit Khandelwal, Michael Tran Duong, Lisa M. Levorse, Winifred Trotman, Alejandra Bahena, Sydney A. Lim, Amanda E. Denning, Eunice Chung, Christopher A. Olm, Hamsanandini Radhakrishnan, Ranjit Ittyerah, Karthik Prabhakaran, Gabor Mizsei, Theresa Schuck, Sheina Emrani, Joaquin A. Vizcarra, John Robinson, Daniel T. Ohm, Jeffrey S. Phillips, Jesse Cohen, Laura E. M. Wisse, John A. Detre, Ilya M. Nasrallah, Christopher A. Brown, Sandhitsu R. Das, Edward B. Lee, M. Dylan Tisdall, David J. Irwin, Corey T. McMillan, David A. Wolk, Paul A. Yushkevich   +30 more
wiley   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, Volume 100, Issue 1, Page 193-205, July 2026.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, Volume 255, Issue 7, Page 671-697, July 2026.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia. [PDF]

INTRODUCTION: Increased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear.

core   +2 more sources