Results 131 to 140 of about 22,140 (207)
Phase 1 study of latozinemab in progranulin‐associated frontotemporal dementia
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Heterozygous mutations in the GRN gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of frontotemporal dementia (FTD) with > 90% penetrance.
Michael Ward +6 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This graphical abstract presents the key design and findings of a 30‐day trial evaluating the safety of fermented D‐allulose in healthy Chinese adults. Fifty eligible adults were randomized to receive either low‐dose (24 g/day, n = 24) or high‐dose (36 g/day, n = 26) D‐allulose for 30 days.
Lijuan Qi +10 more
wiley +1 more source
Natural Sciences, Volume 6, Issue 3, July 2026.The mechanisms driving the progression of NAFLD through NASH, cirrhosis and HCC are unclear. In this study, we have comprehensively analyzed multi‐cohort transcriptomics data of the whole NAFLD spectrum to unlock the paradigm changes in gene expression and its regulation.
Anusha Patodia +5 more
wiley +1 more source
Natural Sciences, Volume 6, Issue 3, July 2026.ABSTRACT Proposing the concept of a conservative revolutionary generally and using the examples of Gregor Mendel, Max Delbrück, and Eric Davidson, I fundamentally call into question Thomas Kuhn's ideas of scientific revolutions. I also highlight some problematic consequences of the increasing appreciation of Kuhn's work among scientists and show that ...
Ute Deichmann
wiley +1 more source
Water Resources Research, Volume 62, Issue 7, July 2026.Abstract Alluvial systems are dynamic, structurally complex environments. Groundwater that is extracted from these systems is widely used for domestic consumption. Numerical models play an important role in the management of this extraction. To provide support for decision‐making, models must assimilate data that inform the spatial and temporal ...
Hugo Delottier +4 more
wiley +1 more source
European Journal of Neurology, Volume 33, Issue 7, July 2026.In 214 patients with advanced Parkinson's disease receiving foslevodopa/foscarbidopa continuous subcutaneous infusion, neuropsychiatric adverse events occurred in 19.2%. Baseline cognitive impairment and hallucinations did not increase risk, whereas preexisting impulse control disorders predicted ICD‐related adverse events.
David Campo‐Caballero +130 more
wiley +1 more source
Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia
European Journal of Neurology, Volume 33, Issue 7, July 2026.Multiplex plasma profiling of 124 CNS‐related proteins in genetic frontotemporal dementia (FTD) identified NfL and NfH as the most consistently altered biomarkers in both GRN‐ and C9orf72‐associated disease. Distinct protein changes emerged across genotypes, including changes in GFAP and VCAM1 in GRN‐FTD, and reduced NPTXR as well as nominally altered ...
Joel Simrén +11 more
wiley +1 more source
Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson\u27s Disease Patients [PDF]
\ua9 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Background: Parkinsonism may be observed in multiple neurodegenerative diseases, including GRN-associated ...
Musacchio T +31 more
core
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis +2 more
wiley +1 more source
Targeting SIK2 with GRN-300 Potentiates Paclitaxel Efficacy in Triple-Negative Breast Cancer. [PDF]
Cancers (Basel)Pina MA +6 more
europepmc +1 more source