Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson's Disease Patients [PDF]
Movement DisordersBackground: Parkinsonism may be observed in multiple neurodegenerative diseases, including GRN-associated frontotemporal dementia (FTD-GRN), complicating the differential diagnosis of Parkinson's disease (PD).
Thomas Musacchio +2 more
exaly +7 more sources
Characterization of Physiological Factors and Performance of Ungrafted GRN Rootstocks Under Moderate Water-Stress Conditions [PDF]
HorticulturaeThe commercial production of grapevines (Vitis vinifera L.) relies heavily on rootstocks that are hybrids of non-vinifera parentage. The relatively newly released GRN rootstocks (GRN-1, GRN-2, GRN-3, GRN-4, and GRN-5) were bred from especially under ...
Jose R. Munoz +7 more
doaj +2 more sources
The unexpected co-occurrence of GRN and MAPT p.A152T in Basque families: Clinical and pathological characteristics. [PDF]
PLoS ONE, 2017 BackgroundThe co-occurrence of the c.709-1G>A GRN mutation and the p.A152T MAPT variant has been identified in 18 Basque families affected by frontotemporal dementia (FTD). We aimed to investigate the influence of the p.A152T MAPT variant on the clinical
Fermin Moreno +12 more
doaj +2 more sources
Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers [PDF]
NeuroImage: Clinical, 2018 Frontotemporal dementia (FTD) is a neurodegenerative disease with a strong genetic basis. Understanding the structural brain changes during pre-symptomatic stages may allow for earlier diagnosis of patients suffering from FTD; therefore, we investigated ...
Karteek Popuri +13 more
doaj +2 more sources
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses [PDF]
Molecular NeurodegenerationBackground GPNMB has been discussed as a potential therapeutic target in GRN-mediated neurodegeneration, based on the observed reproducible upregulation in FTD-GRN cerebrospinal fluid (CSF) and post-mortem brain.
Rebecca L. Wallings +8 more
doaj +2 more sources
, 2022 Lung-specific gene regulatory network (GRN) generated using CoDeS3D.
Evgeniia Golovina (4441837)
core +1 more source
, 2022 eQTLs from lung-specific gene regulatory network (GRN) generated by CoDeS3D.
Evgeniia Golovina (4441837)
core +1 more source
Reduced proliferation and minimal mutant p53 expression in cholangiocytes in hamsters infected with ΔOv-grn-1 genotype liver flukes. [PDF]
, 2022 Representative images of biliary cells that incorporated BrdU from regions proximal to flukes in control, ΔOv-grn-1 and ΔOv-tsp-2 groups (A). The boxed region in the upper image is expanded in the lower panel. The brown arrow highlights the positive BrdU-
Sujittra Chaiyadet (6743609) +9 more
core +1 more source
GRN perturbations via IQCELL. [PDF]
, 2022 (A) Systematic gene perturbations. The expression states of the model attractor (left). The percentage of similarity between the attractors (vertical axis) and the binarized expressions of CLP, ETP, DN2A, DN2B, and DN3A cells (horizontal axis) [38 ...
Ayako Yachie-Kinoshita (446765) +8 more
core +1 more source
AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b−/−Grn−/− mice [PDF]
, 2023 Summary: Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are currently in clinical trials.
Michael Kurnellas +12 more
core +1 more source