Results 41 to 50 of about 22,140 (207)
The GRN concept as a guide for evolutionary developmental biology [PDF]
, 2023 Organismal phenotypes result largely from inherited developmental programs, usually executed during embryonic and juvenile life stages. These programs are not blank slates onto which natural selection can draw arbitrary forms.
Feigin, C +3 more
core +1 more source
Frontiers in Genetics, 2022 Accurate inference of gene regulatory networks (GRNs) is important to unravel unknown regulatory mechanisms and processes, which can lead to the identification of treatment targets for genetic diseases.
Deniz Seçilmiş +2 more
doaj +1 more source
Acta Neuropathologica Communications, 2020 Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin (PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN mutations cause neuronal ceroid lipofuscinosis-11 (CLN11), a lysosome storage disease ...
Meixiang Huang +11 more
doaj +1 more source
A patient with recurrent strokes: multimodal imaging reveals two possible causes
Romanian Journal of Cardiology, 2022 An underlying cardio-embolic cause can be identified in a fifth of stroke patients. Cardiac tumors occur rarely in routine clinical practice but can cause severe complications such as heart failure, valve dysfunction, embolic events, or sudden cardiac ...
Giusca Sorin +3 more
doaj +1 more source
Cognitive reserve in granulin-related frontotemporal dementia: from preclinical to clinical stages. [PDF]
PLoS ONE, 2013 OBJECTIVE: Consistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment.
Enrico Premi +11 more
doaj +1 more source
Integrated multiomics analysis highlights the immunosuppressive role of granulin precursor positive macrophages in hepatocellular carcinoma [PDF]
PeerJIt has been reported that tumor-associated macrophages (TAMs) play a complicated role in cancer occurrence and development, immune escape, and immune checkpoint blockade (ICB) resistance.
Jun Li +5 more
doaj +2 more sources
Subcortical and Deep Cortical Atrophy in Frontotemporal Dementia due to Granulin Mutations
Dementia and Geriatric Cognitive Disorders Extra, 2014 Background/Aims: Parkinsonism is often associated with symptoms of frontotemporal dementia (FTD), but its pathogenesis has been largely neglected. In genetic inherited FTD-related granulin (GRN) mutations, parkinsonism is an early sign, and it is more ...
Enrico Premi +7 more
doaj +1 more source
Problematic Internet Use in Frontotemporal Dementia: A Case Series
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The present study investigated problematic internet use (PIU) among 61 patients with frontotemporal dementia (FTD) compared to a cohort of 354 patients with mild cognitive impairment (MCI) and Alzheimer's dementia. PIU was identified in 22.9% of FTD patients compared to only 0.8% of AD patients (p < 0.001). Behaviors included compulsive social
Daniele Urso +9 more
wiley +1 more source
A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley +1 more source