Results 51 to 60 of about 22,140 (207)

Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities

Frontiers in Molecular Neuroscience, 2021
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Heterozygous loss-of-function mutations in progranulin (GRN) induce haploinsufficiency of the protein and are associated with up to one-
Joke Terryn, Joke Terryn, Catherine M. Verfaillie, Philip Van Damme, Philip Van Damme, Philip Van Damme   +5 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

GRN exacerbated lupus nephritis in lupus model. [PDF]

, 2013
BALB/c mice were administrated intramuscularly with 100 µg/mouse pGRN or pcDNA3.1 to overexpress GRN, intravenously injected with LV-shGRN or LV-shNC (2×108 molecules/mouse) to down-regulate GRN expression.
Wei Xu (28953), Zhenke Wen (219096), Sidong Xiong (131254), Xi Chen (35903)   +3 more
core   +1 more source

[Spanish guide for neonatal stabilization and resuscitation 2021: Analysis, adaptation and consensus on international recommendations]. [PDF]

, 2021
Tras la publicación de las recomendaciones, consensuadas por todas las sociedades científicas a través del ILCOR, a finales del año 2020, el GRN-SENeo inició un proceso de análisis y revisión de los principales cambios desde las últimas guías, a los que ...
Izquierdo-Renau, Montserrat, Avila-Alvarez, Alejandro, Zeballos-Sarrato, Gonzalo, Ruiz-Campillo, Cesar W, Escrig-Fernandez, Raquel, Gomez-Robles, Celia, Iriondo-Sanz, Martin   +6 more
core   +1 more source

Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration [PDF]

, 2013
Mutations in progranulin gene (GRN) are the most common cause of autosomal dominant familial frontotemporal lobar degeneration (FTLD). In addition, GRN variability influences the risk to develop the disease in non-carriers (sporadic FTLD).
S. F. Cappa, A.C. Altamura, E. Scarpini, N. Bresolin, C. Fenoglio, B. Arosio, C. D'Addario, D. Mari, M. Maccarrone, D. Galimberti, B. Dell'Osso, A. Marcone, C. Cerami, M. C. Palazzo   +13 more
core   +3 more sources

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes

Scientific Reports
Agatston score, the degree of lumen narrowing categorized by CAD-RADS, high-risk atherosclerotic plaque features and pericoronary adipose tissue attenuation (PCAT) are parameters, which can be assessed non-invasively by coronary computed tomography ...
Subin Lee, Alexander Giesen, Dimitrios Mouselimis, Loris Weichsel, Andreas A. Giannopoulos, Max Nunninger, Matthias Renker, Florian André, Norbert Frey, Grigorios Korosoglou   +9 more
doaj   +1 more source

Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration

Acta Neuropathologica Communications, 2023
Genetic variants in TMEM106B are a common risk factor for frontotemporal lobar degeneration and the most important modifier of disease risk in patients with progranulin (GRN) mutations (FTLD-GRN). TMEM106B is encoding a lysosomal transmembrane protein of
Anne-Sophie Cabron, Uwe Borgmeyer, Julia Richter, Helga Peisker, Katharina Gutbrod, Peter Dörmann, Anja Capell, Markus Damme   +7 more
doaj   +1 more source

GRN−/− iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis

Neurobiology of Disease, 2022
Heterozygous mutations in the gene coding for progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) while homozygous mutations are linked to neuronal ceroidolipofuscinosis (NCL).
Patrizia Bossolasco, Sara Cimini, Emanuela Maderna, Donatella Bardelli, Laura Canafoglia, Tiziana Cavallaro, Martina Ricci, Vincenzo Silani, Gianluca Marucci, Giacomina Rossi   +9 more
doaj   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source