Results 71 to 80 of about 22,140 (207)

Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis [PDF]

, 2007
There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
Rogaeva, K, Robertson, J, Morrison, Karen, Sato, C, Xiao, S, Goodall, Emily, Pall, Hardev, Kawarai, T, Zinman, LH   +8 more
core   +3 more sources

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations

The Journal of Clinical Investigation, 2023
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in the thalamocortical circuit
Elise Marsan, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, Martina de Majo, Cristina Mora, Jessica Blumenfeld, Alissa N. Li, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Erik M. Ullian, Matthew F. Krummel, Arnold R. Kriegstein, Eric J. Huang   +18 more
doaj   +1 more source

Loss, persistence and reversal of phenotypic traits

Biological Reviews, EarlyView.
ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni, Giuseppe Fusco, Filippo Nicolini, Heather Bruce, Andrea Luchetti   +4 more
wiley   +1 more source

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations

Acta Neuropathologica Communications, 2019
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Andrew E. Arrant, Jonathan R. Roth, Nicholas R. Boyle, Shreya N. Kashyap, Madelyn Q. Hoffmann, Charles F. Murchison, Eliana Marisa Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Erik D. Roberson   +12 more
doaj   +1 more source

Distal retrieval of dislodged and migrated guidewires after retrograde puncture of the deep femoral and dorsal pedal artery. A case series

Clinical Case Reports, 2021
We report on retrograde retrieval of the soft end of dislodged guidewires during complex interventions. Interventionalists may consider this as an option for the endovascular management of this complication if an antegrade retrieval is not possible or ...
Grigorios Korosoglou, Sorin Giusca, Muliadi Antaredja, Andrej Schmidt, Erwin Blessing   +4 more
doaj   +1 more source

Building phenotypic character matrices for phylogenetic inference: exploration of 35 years of practice

Biological Reviews, EarlyView.
ABSTRACT Recent methodological development in phylogenetic inference has focused predominantly on molecular data. However, renewed interest in other data types, particularly morphological data, has followed from the increased recognition of the power of total evidence and tip‐dating approaches, including fossil data, for inference of time‐scaled trees ...
Melanie J. Hopkins, Mark C. Nikolic, James D. Holmes, Daniela S. Monti, Ernesto E. Vargas‐Parra, Russell D.C. Bicknell, Gregory D. Edgecombe, Katherine Jordan‐Burmeister, John R. Paterson, Shravya Srivastava‐Losey   +9 more
wiley   +1 more source

Reduced miR-659-3p levels correlate with progranulin increase in hypoxic conditions: implications for frontotemporal dementia.

Frontiers in Molecular Neuroscience, 2016
Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and activated microglia.
Paola ePiscopo, Margherita eGrasso, Francesca eFontana, Alessio eCrestini, Maria ePuopolo, Valerio eDel Vescovo, Aldina eVenerosi, Gemma eCalamandrei, Sebastian F Vencken, Catherine M Greene, Annamaria eConfaloni, Michela Alessandra Denti   +11 more
doaj   +1 more source

A shining starlet: Nematostella vectensis as a model for developmental, regenerative, and comparative biology

Developmental Dynamics, EarlyView.
Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis, Zachary Horowitz, Michael Shribak, Karen Echeverri   +3 more
wiley   +1 more source

GRN variability contributes to sporadic frontotemporal lobar degeneration [PDF]

, 2009
Mutations in the progranulin gene (GRN) are responsible for familial FTLD with ubiquitin pathology (FTLD-U). However, there are controversial data regarding the contribution of GRN variability to sporadic FTLD.
S. Gallone, Luisa Benussi, Cappa, Stefano, N. Bresolin, Claudio Mariani, Cortini, Francesca, M. Serpente, D. Scalabrini, Eliana Venturelli, Francesca Clerici, Restelli, Ilaria, L. Benussi, Binetti, Giuliano, A. Marcone, Galimberti, Daniela, Benussi, Luisa, Innocenzo Rainero, E. Venturelli, E. Scarpini, Chiara Villa, S. Cappa, Elio Scarpini, Alessandra Marcone, Filippo Martinelli Boneschi, Clerici, Francesca, I. Restelli, I. Rainero, Stefano Cappa, Salvatore Gallone, Mariani, Claudio, Gallone, Salvatore, F. M. Boneschi, Boneschi, Filippo Martinelli, F. Clerici, D. Galimberti, M. T. Giordana, F. Martinelli Boneschi, Roberta Ghidoni, Daniela Galimberti, Chiara Fenoglio, R. Ghidoni, Maria Serpente, Scalabrini, Diego, C. Villa, Nereo Bresolin, Venturelli, Eliana, Francesca Cortini, Rainero, Innocenzo, C. Mariani, Giuliano Binetti, M. Giordana, Fenoglio, Chiara, Scarpini, Elio, Marcone, Alessandra, C. Fenoglio, Bresolin, Nereo, G. Binetti, Diego Scalabrini, Villa, Chiara, F. Cortini, Ghidoni, Roberta, Maria Teresa Giordana, Serpente, Maria, Ilaria Restelli, Giordana, Maria Teresa   +64 more
core   +1 more source