Results 61 to 70 of about 22,140 (207)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

grn and iro expression at the anterior midgut. [PDF]

, 2018
(A) Partial overlap between grn and iro expression at the anterior midgut; (A´) magnification of the anterior midgut region. (B) Same image as in A only in the red channel to visualise iro expression; (B´) magnification of the anterior midgut region. (C)
Jordi Casanova (582916), Beatriz Hernández de Madrid (4922929)   +1 more
core   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Modeling of genetic regulatory networks in the differentiation of neural crest stem cells to sensory neurons by means of boolean networks

Revista Facultad de Ingeniería Universidad de Antioquia, 2011
In the present study we have generated a GRN comprising the process by which neural crest stem cells develop to two types of sensory neurons (Propioceptors and Nocioceptors).
Jorge Marcelo Aráus Patiño, Helena Groot Restrepo, Andrés Fernando González Barrios   +2 more
doaj  

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Rotarex Debulking in a Subtotal Occlusion of the Common Femoral Artery After Intimal Protrusion Caused by a Vascular Closure (StarClose) Device

Clinical Case Reports
We present a case of a 72‐year‐old female patient who presented with resting pain in her right limb 3 weeks after coronary intervention via femoral access.
Theodoros Moysidis, Daniel Herzenstiel, Grigorios Korosoglou   +2 more
doaj   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Core features of frontotemporal dementia recapitulated in progranulin knockout mice

Neurobiology of Disease, 2012
Frontotemporal dementia (FTD) is typified by behavioral and cognitive changes manifested as altered social comportment and impaired memory performance. To investigate the neurodegenerative consequences of progranulin gene (GRN) mutations, which cause an ...
N. Ghoshal, J.T. Dearborn, D.F. Wozniak, N.J. Cairns   +3 more
doaj   +1 more source

Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon

Cells, 2020
Granulins (GRN) are secreted factors that promote neuronal survival and regulate inflammation in various pathological conditions. However, their roles in physiological conditions in the brain remain poorly understood.
Alessandro Zambusi, Özge Pelin Burhan, Rossella Di Giaimo, Bettina Schmid, Jovica Ninkovic   +4 more
doaj   +1 more source