Results 81 to 90 of about 46,126 (304)
Generation of Grna and Grnb KOs using ZFNs.
, 2015 A: Schematic illustration of human GRN and zebrafish Granulins. Human GRN has 7 ½ granulin domains, while 12 granulin domains are found in Grna, 9 in Grnb, and 1 ½ in Grn1 and Grn2. Grey: signal peptide. Black numbers: amino acids.
Christian Haass (261040) +4 more
core +1 more source
gRNA target sites for lrrk2 locus deletion.
, 2021 gRNA target sites for lrrk2 locus deletion.
Volker Kroehne (672204) +14 more
core +1 more source
PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Polycomb group factor 1 (PCGF1) and coiled‐coil domain‐containing protein 34 (CCDC34) have been implicated in tumorigenesis in multiple malignancies. However, their biological functions and prognostic significance in glioma remain poorly defined.
Yuanbing Chen +7 more
wiley +1 more source
A Golden Gate-based Protocol for Assembly of Multiplexed gRNA Expression Arrays for CRISPR/Cas9
Bio-Protocol, 2016 The CRISPR (clustered regularly interspaced short palindromic repeats)-associated protein 9 (Cas9) has become the most broadly used and powerful tool for genome editing.
Johan Vad-Nielsen +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Clustered regularly interspaced short palindromic repeats (CRISPR)-based HIV-1 genome editing has shown promising outcomes in in vitro and in vivo viral infection models. However, existing HIV-1 sequence variants have been shown to reduce CRISPR-mediated
Cheng-Han Chung +15 more
doaj +1 more source
MOESM12 of Gene repression via multiplex gRNA strategy in Y. lipolytica
, 2018 Additional file 12: Fig. S6. Photos and its corresponding microscopic images of the interfered strains by dCas9-Multi system. Four related plasmids were transformed into strain VioABE-K8GFP respectively to form four strains: control (means no gRNA ...
Hong Liu (50694) +7 more
core +1 more source
Target sequences of gRNA used in this study.
, 2022 This spreadsheet provides the target sequences of gRNA. (XLSX)
Yumiko Saga (176901) +1 more
core +1 more source
Advanced Science, EarlyView.In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang +11 more
wiley +1 more source
Scientific ReportsLegumain (or asparagine endopeptidase/AEP) is a lysosomal cysteine endopeptidase associated with increased invasive and migratory behavior in a variety of cancers.
Yue Wang +4 more
doaj +1 more source
Efficient genome editing using tRNA promoter-driven CRISPR/Cas9 gRNA in Aspergillus niger. [PDF]
PLoS ONE, 2018 As a powerful tool for fast and precise genome editing, the CRISPR/Cas9 system has been applied in filamentous fungi to improve the efficiency of genome alteration.
Letian Song +4 more
doaj +1 more source