Retrograde Ret signaling controls sensory pioneer axon outgrowth
eLife, 2019 The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret,
Adam Tuttle +4 more
doaj +1 more source
The Neuron Navigators: Structure, function, and evolutionary history
Frontiers in Molecular Neuroscience, 2023 Neuron navigators (Navigators) are cytoskeletal-associated proteins important for neuron migration, neurite growth, and axon guidance, but they also function more widely in other tissues.
Regina M. Powers +5 more
doaj +1 more source
Beam effect on electromagnetic ion-cyclotron waves with general loss ? cone distribution function in an anisotropic plasma-particle aspect analysis [PDF]
, 2007 International audienceThe effect of upgoing ion beam and temperature anisotropy on the dispersion relation, growth rate, parallel and perpendicular resonant energies, and marginal instability of the electromagnetic ion cyclotron (EMIC) waves, with ...
Ahirwar, G., Tiwari, M. S., Varma, P.
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A
eLife, 2021 Variants in the high confident autism spectrum disorder (ASD) gene ANK2 target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms.
Blake A Creighton +12 more
doaj +1 more source
Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and Semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons [PDF]
, 2013 Growth cone motility and morphology, which are critical for axon guidance, are controlled through intracellular events such as actin cytoskeletal reorganization and vesicular trafficking.
Goshima Yoshio +4 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders
Cells, 2020 Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the ...
Diana C. Muñoz-Lasso +3 more
doaj +1 more source
Early ontogenetic male cone production in Pinus radiata : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology at Massey University [PDF]
, 2000 The tree breeding industry is interested in early ontogenetic male cone production in Pinus radiata in order to maximise the rate at which successive generations can be bred.
Welsh, Shayne Kevin
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source