Results 1 to 10 of about 6,381,744 (358)
Oncogenic PIK3CA corrupts growth factor signaling specificity. [PDF]
Mol Syst BiolTechnical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. We introduce a kinetic,
Madsen RR +14 more
europepmc +4 more sources
Single Cell Center of Mass for the Analysis of BMP Receptor Heterodimers Distributions
Journal of Imaging, 2021 At the plasma membrane, transmembrane receptors are at the interface between cells and their environment. They allow sensing and transduction of chemical and mechanical extracellular signals.
Hendrik Boog +2 more
doaj +1 more source
Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive human malignancy and intrinsically resistant to conventional therapies. YAP1, as a key downstream effector of the Hippo pathway, plays an important role in tumorigenesis including PDAC ...
Chao Gao +14 more
doaj +1 more source
Cancer Medicine, 2023 Epithelium‐specific ETS transcription factor 1 (ESE1) has been implicated in epithelial homeostasis, inflammation, as well as tumorigenesis, and cancer progression.
Hui‐Jing Xu +12 more
doaj +1 more source
FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes
Frontiers in Cell and Developmental Biology, 2021 Adipocytes not only function as energy depots but also secrete numerous adipokines that regulate multiple metabolic processes, including lipid homeostasis.
Yu-Qing Lv +8 more
doaj +1 more source
FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress
Molecular Medicine, 2022 Background Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are devastating clinical disorders with high mortality, and for which more effective therapies are urgently needed.
Qhaweni Dhlamini +11 more
doaj +1 more source
Cells, 2022 Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with dire consequences and in urgent need of improved therapies. Compelling evidence indicates that damage or dysfunction of AT2s is of central importance in the development ...
Yu-Qing Lv +12 more
doaj +1 more source
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
Frontiers in Cell and Developmental Biology, 2020 Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic ...
Majid Mossahebi-Mohammadi +4 more
doaj +1 more source
Growth and Growth Factors [PDF]
Yearbook of Paediatric Endocrinology, 2014 The majority of articles selected for this chapter refer to novel pathophysiological mechanisms that have recently been elucidated. Levels of expression and methylation as well as specific polymorphisms in the IGF2 gene were shown to play a key role not only in fetal growth but also in early postnatal weight gain.
Elena Inzaghi, Stefano Cianfarani
openaire +2 more sources
Growth, growth factors and diabetes [PDF]
European Journal of Endocrinology, 2004 Type 1 diabetes mellitus (T1DM) and other chronic diseases in children are well known to adversely affect linear growth and pubertal development. In the years immediately following the introduction of insulin therapy, short stature was consistently reported in children with T1DM.
CHIARELLI, Francesco +2 more
openaire +4 more sources