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Growth and Growth Factors [PDF]
Yearbook of Paediatric Endocrinology, 2014 The majority of articles selected for this chapter refer to novel pathophysiological mechanisms that have recently been elucidated. Levels of expression and methylation as well as specific polymorphisms in the IGF2 gene were shown to play a key role not only in fetal growth but also in early postnatal weight gain.
Elena Inzaghi, Stefano Cianfarani
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Growth, growth factors and diabetes [PDF]
European Journal of Endocrinology, 2004 Type 1 diabetes mellitus (T1DM) and other chronic diseases in children are well known to adversely affect linear growth and pubertal development. In the years immediately following the introduction of insulin therapy, short stature was consistently reported in children with T1DM.
CHIARELLI, Francesco +2 more
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Growth and Growth Factors [PDF]
, 2008 The last year has again seen some major advances in the Growth and Growth Factors field. Significant advances have been made in our understanding of the genetics of growth. For example, mutations in the pericentrin gene PCNT are associated with both primordial dwarfism and Seckel syndrome.
Mehul T. Dattani, Evelien F. Gevers
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Growth and Growth Factors [PDF]
, 2005 SOCS2 inactivation, which leads to growth hormone hypersensitivity and overgrowth, is selected as the mechanism of the year in this chapter. The second paper shows that PPAR plays a role in the growth of male mice. Under new paradigms, we learn that the disruption of a paternally expressed gene from the Gnas locus, XL s, is associated with poor ...
Régis Coutant, Natacha Bouhours-Nouet
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Annual Review of Biochemistry, 1972 During the course of the studies on the nerve growth factor of the submaxillary gland of the male mouse (1), it was observed that extracts of these glands, when injected into newborn mice, caused precocious opening of the eyelid and eruption of the incisors. A polypeptide responsible for this effect has been isolated (2).
Graham Carpenter, S Cohen
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Growth factors and goitrogenesis [PDF]
Journal of Endocrinology, 1999 By combining data from studies of multinodular non-toxic goitre (MNTG) with data from rat models of goitre induction and in vitro models, a map of the growth factors involved in goitrogenesis has been constructed. We have addressed the roles of the insulin-like growth factors, transforming growth factors, fibroblast growth factors, endothelins, etc. We
Bidey, S. P., Hill, D. J., Eggo, M. C.
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, 2006 The most exciting recent advances in skeletal growth factor biology have emerged from genetic and transgenic approaches, and these have greatly enhanced our understanding of the role played by growth factors in the developing and adult skeleton. A more coherent picture of the interplay between different hormones, growth factors, and cytokines during ...
Hulley, P, Russell, G, Croucher, P
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Fibroblast growth factors [PDF]
Current Biology, 2003 What are they? Fibroblast growth factors (FGFs) are a family of small (20–30kDa) intercellular signalling proteins which are frequently found to be glycosylated. The first draft of the human genome identified 29 potential FGF genes, and so far transcripts have been identified for 23 of them.
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Growth Factor Regulation of Growth Factors in Articular Chondrocytes [PDF]
Journal of Biological Chemistry, 2009 Several lines of evidence indicate that polypeptide growth factors are important in articular cartilage homeostasis and repair. It is not yet clear how these growth factors are regulated. We tested the hypothesis that the growth factors responsible for regulating cartilage are themselves regulated by growth factors.
George J. Eckert +3 more
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Growth Factors in the Nucleolus? [PDF]
The Journal of Cell Biology, 1998 In eukaryotic cells containing tandem repeated ribosomal RNA genes, there appears a specialized region of chromatin, carrying out gene transcription, rRNA processing, and nascent ribosomal subunit assembly—the nucleolus.
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